Immunomodulation and antitumor activity by a polysaccharide–protein complex from Lycium barbarum

Gan, Liu; Zhang, Sheng Hua; Yang, Xiang Liang; Xu, Hui

doi:10.1016/j.intimp.2004.01.023

Cited by 252 publications

(178 citation statements)

References 14 publications

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“…Apoptosis and cell-cycle arrest are both mechanisms for cytotoxic anticancer drugs work in cancer treatment [31,32]. Previous studies had shown that LBP could induce cancer cell apoptosis and cell-cycle arrest [1][2][3][4][5]. In our study, we found that LBP3 disrupted MMP and induced H22 cell apoptosis.…”

Section: Discussionsupporting

confidence: 55%

“…The anticancer effects of LBP were also demonstrated in tumor-bearing mice. Gan [4] revealed that a polysaccharide-protein complex from Lycium barbarum could significantly inhibit the growth of transplantable sarcoma S180 and improved the immune system in S180-bearing mice. Another study led by Zhang [5] found that LBP could obviously depress the death rate of H22 tumor-bearing mice and diminish gross tumor volume and weight.…”

Section: Introductionmentioning

confidence: 99%

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Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Deng

Li²,

Luo

et al. 2017

Food & Nutrition Research

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The antitumor activity of Lycium barbarum polysaccharide (LBP) has been reported, but the structure-bioactivity relationship has still not been fully elucidated. In this study, four watersoluble LBP fractions with serial different molecular weights (MWs) were separated from LBP, designated LBP-2, LBP-3, LBP-4, and LBP-5. After a characteristic analysis, the relationship between MW and antitumor activity of LBP was investigated both in vitro using murine hepatoma H22 cells and in vivo using H22 tumor-bearing mice. In vitro, the results showed that all the LBP fractions had significant inhibition on H22 cells, in which LBP-3 had the best activity. LBP-3 could induce apoptosis, mitochondrial membrane potential destruction, and S phase arrest in H22 cells. In vivo, the results showed that LBP-2, LBP-3, LBP-4, and LBP-5 could inhibit the tumor growth in H22 tumor-bearing mice by 18.18%, 37.97%, 9.09%, and 14.44%, respectively. However, only LBP-3 was able to decrease the tumor weight significantly in H22 tumor-bearing mice. Meanwhile, all the LBP fractions did not show significant toxicity to murine splenocytes, thymus, and spleen. Taken together, these results demonstrated that the antitumor activity of LBP was closely related to its MW, and LBP-3 with medium MW (40-350 kDa) was the main active fraction. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Deng

Li²,

Luo

et al. 2017

Food & Nutrition Research

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show abstract

“…The active components of Lycium barbarum primarily contain water-soluble polysaccharides (Chen and Mu, 2007). They could be extracted with hot water followed by precipitation with ethanol to obtain high quantity of polysaccharides (Zhi et al, 2004;Gan et al, 2004;Zhang et al, 2004). LBP have been recently studied for their physiological and pharmaceutical activities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of hypoglycemic activity of the polysaccharides extracted from Lycium barbarum

Jing¹,

Cui²,

Feng³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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A study was undertaken to evaluate the hypoglycemic activity of polysaccharide extracted from Lycium barbarum (LBP). The various parameters studied included body weight (bw), fasting blood glucose levels (FBG), total cholesterol (TC) and triglyceride (TG) in diabetic and normal mice. LBP treatment (20, 40 mg/ kg body weight) for 28 days resulted in a significant decrease in the concentration of FBG, TC and TG in diabetes mellitus mice. Furthermore, LBP significantly increased body weight. The data demonstrated LBP at the dose of 40 mg/kg bw exhibited the better effect.

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“…Enhanced or inhibited apoptosis in lymphocyte can lead to immunodeficiency or autoimmunity, or lymphoma [6]. LBP plays an important role in lymphocyte proliferation and cytokine production [7,8]. A recent study reported that LBP has beneficial effects on spermatogenesis through regulation of apoptosis and antioxidant activity in diabetic male mice [9].…”

Section: Introductionmentioning

confidence: 99%

Impact of Lycium barbarum polysaccharide on apoptosis in Mycoplasma-infected splenic lymphocytes

Huang¹,

Zheng²,

Xu³

2017

Trop. J. Pharm Res

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Immunomodulation and antitumor activity by a polysaccharide–protein complex from Lycium barbarum

Cited by 252 publications

References 14 publications

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Antitumor activity of Lycium barbarum polysaccharides with different molecular weights: an in vitro and in vivo study

Evaluation of hypoglycemic activity of the polysaccharides extracted from <i>Lycium barbarum</i>

Impact of <i>Lycium barbarum</i> polysaccharide on apoptosis in <i>Mycoplasma</i>-infected splenic lymphocytes

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