Therapeutic Evaluation of Oxantel Pamoate (1,4,5,6-Tetrahydro-1-Methyl-2-[Trans-3-Hydroxystyryl] Pyrimidine Pamoate) in Severe Trichuris trichiura Infection *

Clubbing and whipworm infestation.

“…With eradication of the infestation clubbing reversed in about 3 months. This is similar to experience reported from Malaysia where it was thought the clubbing was most closely related to the heavy worm load and the chronicity of the diarrhoea (Lee et al, 1976). It does appear to be related to the presence of Trich.…”

“…Most of these findings including digital clubbing have been described in association with Trich. trichiura infestation (Kamath, 1973;Lee et al, 1976). However, the total clinical picture does not seem to be generally recognised.…”

“…The best known of these are Crohn's disease (Chrispin and Tempany, 1967;Fielding and Cooke, 1971;Perry et al, 1972), ulcerative colitis (Jalan et al, 1970;Perry et al, 1972), and coeliac disease (Hamilton et al, 1969). More recently clubbing has also been reported in gastro-oesophageal reflux with protein-losing enteropathy (Herbst et al, 1976) and in intestinal parasitic infections (Kamath, 1973;Lee et al, 1976).…”

Control of Nematode Parasites with Agents Acting on Neuro-Musculature Systems: Lessons for Neuropeptide Ligand Discovery

“…There are the N-subtypes (nicotine and oxantel preferring), the L-subtype (levamisole and pyrantel preferring) and the B-subtypes (bephenium-preferring) in Ascaris suum (Qian et al , 2006). It is interesting that levamisole resistant Haemonchus contortus remain sensitive to bephenium (Sangster et al , 1991) and that Trichuris trichuris is not sensitive to pyrantel but is sensitive to oxantel (Lee et al , 1976). These observations illustrate the fact that even if the mode of action of a class of compounds appears to be similar, it is possible that the different members of the class of compounds have different selectivities for different subtypes of the receptor target site.…”

Drugs Originating from the Screening of Organic Chemicals

“…100 This activity against whipworm infection compensated for its narrow spectrum of anthelmintic activity, and became the principal clinical application. 101 NIFEDIPINE Because 1,4-dihydropyridines played an important role in biochemical processes yet had never been investigated pharmacologically, the medicinal chemistry group at the Bayer laboratories submitted a variety of these for screening. After some of these compounds were found to exhibit a measurable effect on cardiac output, more than 2000 analogues were synthesised and screened.…”