Therapeutic evaluation of sustained-releasing praziquantel (SRP) for clonorchiasis: Phase 1 and 2 clinical studies

Choi, Mihye; Chang, Byung Chan; Lee, Seung Jin; Jang, In‐Jin; Shin, Sang Goo; Kho, Weon-Gyu; Chun, Jin Ho; Hong, Sung Tae

doi:10.3347/kjp.2006.44.4.361

Cited by 6 publications

(5 citation statements)

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“…When metabolized praziquantel in bile juice contacts C. sinensis in the intrahepatic bile duct, the worms are paralyzed and dispatched from the bile duct mucosa [10], [17]. The paralyzed worms slowly flow down to the intestine with bile.…”

Section: Discussionmentioning

confidence: 99%

“…Praziquantel is known to induce paralysis by sustained musculature contraction and tegumental disruption of target worms via increase of permeability to Ca 2+ on the cell membrane of the worms [16] . When metabolized praziquantel in bile juice contacts C. sinensis in the intrahepatic bile duct, the worms are paralyzed and dispatched from the bile duct mucosa [10] , [17] . The paralyzed worms slowly flow down to the intestine with bile.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis

et al. 2011

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BackgroundStool examination by counting eggs per gram of feces (EPGs) is the best method to estimate worm burden of Clonorchis sinensis in infected humans. The present study investigated a correlation between EPGs and worm burden in human clonorchiasis.Methods and FindingsA total of 60 residents, 50 egg-positive and 10 egg-negative, in Sancheong-gun, Korea, participated in this worm collection trial in 2006–2009. They were diagnosed by egg positivity in feces using the Kato-Katz method. After administration of praziquantel, they were purged with cathartics on the next day, and then discharged adult worms were collected from their feces. Their EPGs ranged from 0 to 65,544. Adult worms of C. sinensis were collected from 17 egg-positive cases, and the number of worms ranged from 1 to 114 in each individual. A positive correlation between EPGs and numbers of worms was demonstrated (r = 0.681, P<0.001). Worm recovery rates were 9.7% in cases of EPGs 1–1,000 and 73.7% in those of EPGs over 1,000. No worms were detected from egg-negative subjects. Maximum egg count per worm per day was roughly estimated 3,770 in a subject with EPGs 2,664 and 106 collected worms.ConclusionsThe numbers of the worms are significantly correlated with the egg counts in human clonorchiasis. It is estimated that at least 110 worms are infected in a human body with EPGs around 3,000, and egg productivity of a worm per day is around 4,000.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis

et al. 2011

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“…Tribendimidine has proven highly effective for treating C. sinensis in vitro and in rats and hamsters [ 51 , 52 ]. Two recent comparative clinical studies demonstrated that compared to PZQ, tribendimidine is as efficacious for the treatment of C. sinensis infection and in some dosage regimens is even more convenient and effective (Table 1 ) [ 53 – 57 ]. Other drugs such as artemether, artesunate, OZ78 and mebendazole have also been evaluated for treating C. sinensis infection in animal models [ 58 , 59 ].…”

Section: Reviewmentioning

confidence: 99%

“… CR: 60 % (12/20), side effects. [ 57 ] Tribendimidine Orally, 400 mg once. Co-infection with other helminthes.…”

Section: Reviewmentioning

confidence: 99%

Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control

2016

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Clonorchiasis, caused by Clonorchis sinensis (C. sinensis), is an important food-borne parasitic disease and one of the most common zoonoses. Currently, it is estimated that more than 200 million people are at risk of C. sinensis infection, and over 15 million are infected worldwide. C. sinensis infection is closely related to cholangiocarcinoma (CCA), fibrosis and other human hepatobiliary diseases; thus, clonorchiasis is a serious public health problem in endemic areas. This article reviews the current knowledge regarding the epidemiology, disease burden and treatment of clonorchiasis as well as summarizes the techniques for detecting C. sinensis infection in humans and intermediate hosts and vaccine development against clonorchiasis. Newer data regarding the pathogenesis of clonorchiasis and the genome, transcriptome and secretome of C. sinensis are collected, thus providing perspectives for future studies. These advances in research will aid the development of innovative strategies for the prevention and control of clonorchiasis.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-016-0166-1) contains supplementary material, which is available to authorized users.

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“…In clonorchiasis patients, a sustained-release formulation was tested to allow for a single-dose treatment with praziquantel. Despite a similar area under the concentration-time curve, the sustained-release formulation with lower maximal concentration and peak time showed unsatisfactory efficacy compared with single-dose normal-release praziquantel [ 80 ].…”

Section: Resultsmentioning

confidence: 99%

Lack of Clinical Pharmacokinetic Studies to Optimize the Treatment of Neglected Tropical Diseases: A Systematic Review

Verrest

Dorlo

2016

Clin Pharmacokinet

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IntroductionNeglected tropical diseases (NTDs) affect more than one billion people, mainly living in developing countries. For most of these NTDs, treatment is suboptimal. To optimize treatment regimens, clinical pharmacokinetic studies are required where they have not been previously conducted to enable the use of pharmacometric modeling and simulation techniques in their application, which can provide substantial advantages.ObjectivesOur aim was to provide a systematic overview and summary of all clinical pharmacokinetic studies in NTDs and to assess the use of pharmacometrics in these studies, as well as to identify which of the NTDs or which treatments have not been sufficiently studied.MethodsPubMed was systematically searched for all clinical trials and case reports until the end of 2015 that described the pharmacokinetics of a drug in the context of treating any of the NTDs in patients or healthy volunteers.ResultsEighty-two pharmacokinetic studies were identified. Most studies included small patient numbers (only five studies included >50 subjects) and only nine (11 %) studies included pediatric patients. A large part of the studies was not very recent; 56 % of studies were published before 2000. Most studies applied non-compartmental analysis methods for pharmacokinetic analysis (62 %). Twelve studies used population-based compartmental analysis (15 %) and eight (10 %) additionally performed simulations or extrapolation. For ten out of the 17 NTDs, none or only very few pharmacokinetic studies could be identified.ConclusionsFor most NTDs, adequate pharmacokinetic studies are lacking and population-based modeling and simulation techniques have not generally been applied. Pharmacokinetic clinical trials that enable population pharmacokinetic modeling are needed to make better use of the available data. Simulation-based studies should be employed to enable the design of improved dosing regimens and more optimally use the limited resources to effectively provide therapy in this neglected area.Electronic supplementary materialThe online version of this article (doi:10.1007/s40262-016-0467-3) contains supplementary material, which is available to authorized users.

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Therapeutic evaluation of sustained-releasing praziquantel (SRP) for clonorchiasis: Phase 1 and 2 clinical studies

Cited by 6 publications

References 11 publications

Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis

Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis

Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control

Lack of Clinical Pharmacokinetic Studies to Optimize the Treatment of Neglected Tropical Diseases: A Systematic Review

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