Therapeutic Implications in the Treatment of Aural Pseudomonas Infections Based on In Vitro Susceptibility Patterns

Dohar, Joseph E.; Kenna, Margaret A.; Wadowsky, Robert M.

doi:10.1001/archotol.1995.01890090060012

Cited by 25 publications

(14 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While P aeruginosa, die most common pathogen, is sensitive to ceftazidime, ciprofloxacin, gentamicin, and polymyxin B, and 5 aureus, the second most common pathogen, is sensitive to ciprofloxacin, gentamicin, chloramphenicol, cloxacillin, cotrimoxazole, and erythromycin, only ciprofloxacin, gentamicin, chloramphenicol, and polymyxin B are commercially available as topical preparations for use in the ear. The same authors 15 have reported susceptibilities of 79% and 94%, respectively, for gentamicin and tobramy-cin, the 2 aminoglycosides available as topical preparations. The majority of the remaining organisms were also highly sensitive to ciprofloxacin, gentamicin, and chloramphenicol (Fig 2B-D).…”

Section: Discussionmentioning

confidence: 88%

“…The majority of the remaining organisms were also highly sensitive to ciprofloxacin, gentamicin, and chloramphenicol (Fig 2B-D). Of the oral agents, the combination sulfamethoxazole-trimethoprim has been reported to be the most effective (46%) by Dohar et al 15 As this drug is a nonpseudomonal antibiotic, we did not test its in vitro effectiveness against Pseudomonas. Hence, of the commonly available ear drops, chloramphenicol and polymyxin B are not effective in CSOM, leaving only ciprofloxacin and gentamicin for routine use.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotics in Chronic Suppurative Otitis Media: A Bacteriologic Study

Indudharan¹,

Haq²,

Aiyar³

1999

Ann Otol Rhinol Laryngol

View full text Add to dashboard Cite

Conservative medical management of chronic suppurative otitis media (CSOM) is an important step in achieving a dry ear. Topical antibiotic ear drops and aural toilet form the mainstay of medical management of noncholesteatomatous CSOM. This study analyzes the causal organisms and their sensitivity to various antibiotics. Out of 382 swabs examined, the major organisms isolated were Pseudomonas aeruginosa (27.2%), followed by Staphylococcus aureus (23.6%). The sensitivity of P. aeruginosa was 100% to ceftazidime, 98.9% to ciprofloxacin, 96.3% to gentamicin, and 95.4% to polymyxin B, whereas the sensitivity of S. aureus was 98.6% to ciprofloxacin, 97.4% to cloxacillin sodium, 96.5% to cotrimoxazole, and 90.7% to gentamicin. Pseudomonas aeruginosa was almost completely resistant to ampicillin (97.6%) and chloramphenicol (96.6%), whereas S. aureus was almost completely resistant to ampicillin (73.8%) and polymyxin B (98.3%). Among the available topical antibiotic preparations for use in the ear, we found that ciprofloxacin and gentamicin are the best choices.

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Antibiotics in Chronic Suppurative Otitis Media: A Bacteriologic Study

Indudharan¹,

Haq²,

Aiyar³

1999

Ann Otol Rhinol Laryngol

View full text Add to dashboard Cite

show abstract

“…In those with perforated membranes, however, one also frequently finds other pathogens such as Pseudomonas aeruginosa and Staphylococcus aureus, which probably gain access to the middle ear through the external auditory canal. 1,3,4 There is no standardized treatment for AOM in children with tympanostomy tubes, since the Food and Drug Administration (FDA) has approved no drug for this specific purpose and different specialties have taken different approaches to treatment. Although oral antibiotics are sometimes used, particularly by pediatricians, they have only been demonstrated to be effective in patients with intact membranes and may not be equally effective in children with tympanostomy tubes because of the different spectrum of patho-gens commonly found when tubes are in place.…”

mentioning

confidence: 99%

Topical Ofloxacin Treatment of Otorrhea in Children With Tympanostomy Tubes

Dohar

Garner²,

Nielsen³

et al. 1999

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…Previous S U N~S showed 29 per cent of Psedmonas isolates from horses (n=7), 92 per cent from dogs (n=79) and 96 per cent from humans (n= 1003) ro be sensitive to ticarcillin (Hirsch and Jang 1994, Dohar andothers 1995, Moore andothers 1995).…”

Section: Introductionmentioning

confidence: 95%

Use of ticarcillin in the management of canine otitis externa complicated by Pseudomonas aeruginosa

Nuttall

1998

J of Small Animal Practice

View full text Add to dashboard Cite

Twelve dogs were referred with purulent and proliferative otitis externa. Prior treatment included fluoroquinolones, glucocorticoids and polyvalent ear drops over seven days to five months. In all cases the vertical and horizontal ear canals were inflamed and thickened, with ruptured tympanic membranes in four cases. No abnormalities were seen on radiography of the osseous bullae. Numerous rod bacilli and degenerate neutrophils were seen on cytology. Pseudomonas aeruginosa resistant to fluoroquinolones and gentamicin was cultured in all cases. Treatment was initiated with 1 to 2 mg/kg prednisolone per os once daily, and a cleansing and drying ear cleaner followed by topical administration of injectable ticarcillin solution four times daily. Cases with ruptured tympanae also received 15 to 25 mg/kg ticarcillin three times daily intravenously until the membranes had healed. All cases were anaesthetised for repeated saline ear flushes until no further discharge was evident and no rods were seen on cytology. Topical ticarcillin and the ear cleaner were continued twice daily for 14 days after clinical resolution. The duration of treatment ranged from 14 to 36 days. Treatment was withdrawn in one case which developed a drug reaction. All other cases responded well with no adverse effects.

show abstract

Therapeutic Implications in the Treatment of Aural Pseudomonas Infections Based on In Vitro Susceptibility Patterns

Cited by 25 publications

References 17 publications

Antibiotics in Chronic Suppurative Otitis Media: A Bacteriologic Study

Antibiotics in Chronic Suppurative Otitis Media: A Bacteriologic Study

Topical Ofloxacin Treatment of Otorrhea in Children With Tympanostomy Tubes

Use of ticarcillin in the management of canine otitis externa complicated by Pseudomonas aeruginosa

Contact Info

Product

Resources

About