Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular Pathways

Rahmani, Arshad Husain; Alzohairy, Mohammad A.; Khan, Masood Alam; Aly, Salah M.

doi:10.1155/2014/724658

Cited by 96 publications

(77 citation statements)

References 125 publications

(108 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nigella sativa was the biblical and the prophet Mohammed's curative black cumin, Hippocrates and Doscorides' Melanthion [60,61]. Nigella sativa is also used in Ayurveda and TCM [61].…”

Section: Phenolsmentioning

confidence: 99%

“…Nigella sativa was the biblical and the prophet Mohammed's curative black cumin, Hippocrates and Doscorides' Melanthion [60,61]. Nigella sativa is also used in Ayurveda and TCM [61]. Nigella sativa seed methanolic extract inhibition of Erlich ascites carcinoma in mice led to patenting of thymoquinone and dithymoquinone for additional research [60].…”

Section: Phenolsmentioning

confidence: 99%

“…Thymoquinone and dithymoquinone displayed in vivo cytotoxicity to multidrug resistant cells [60]. Thymoquinone has cytotoxic activity against MCF-7/ Doxorubicin via PTEN, p53, and p21 upregulation; NF-κβ, PI3K-Akt, phase I enzymes, and PPAR inhibition, and phase II enzyme (GST and N-acetyl transferase) activation [61]. Thymoquinone induces caspace-3 apoptosis against Hep-2 cells, whereas caspace-3, -8, and -9 are activated against HL60 p53-myeloid leukemia [61].…”

Section: Phenolsmentioning

confidence: 99%

“…Thymoquinone has cytotoxic activity against MCF-7/ Doxorubicin via PTEN, p53, and p21 upregulation; NF-κβ, PI3K-Akt, phase I enzymes, and PPAR inhibition, and phase II enzyme (GST and N-acetyl transferase) activation [61]. Thymoquinone induces caspace-3 apoptosis against Hep-2 cells, whereas caspace-3, -8, and -9 are activated against HL60 p53-myeloid leukemia [61]. Thymoquinone inhibits COX2, which affects breast, lung, stomach, and pancreatic cancers [61].…”

Section: Phenolsmentioning

confidence: 99%

See 3 more Smart Citations

Nutraceuticals: Curative Integrative Cancer Treatment

Nwanodi¹

2017

Altern Integr Med

View full text Add to dashboard Cite

Statement of Purpose: Although 75% of breast cancer patients may use integrative medicine, only 11.5% earlystage breast cancer patients believe integrative medicine has anticancer activity. The gap in users of and firm believers in integrative medicine indicates a need to increase awareness of integrative medicine's applicability to curative cancer treatment. As diet, nutraceuticals, and traditional Chinese medicine are used by up to 82% of cancer patients who use integrative medicine, this paper focuses on nutraceuticals. As female cancer patients are most likely to use integrative medicine, nutraceuticals specific to breast, cervical, endometrial, and ovarian cancer are reviewed.Methods: PubMed searches in September 2016 and January 2017, and accompanying hand searches were performed for English language, free full text articles published from 2012 onwards. Search terms were combinations of the key words: Homeopathy, phytochemicals, breast cancer, cervical cancer, endometrial cancer, ovarian cancer, cancer, prevention, treatment. Curative nutraceutical treatments were taken from these searches. Supplemental hand searches were performed as needed. Findings:Integrative nutraceutical therapies are based on biologic plausibility. Individual nutraceuticals are frequently comprised of numerous phytochemical types, and have multiple mechanisms of action. Agonistantagonist mechanisms are not exclusive to phytoestrogens, complicating which derivative or whole nutraceutical to use. Research on breast and cervical cancer inhibitors has seemingly outpaced that for endometrial and ovarian cancer. Breast cancer inhibitors include terpenes, isoflavones, organosulphurs, organoselenium compounds, and withanolides. Conclusion and Significance:Potential nutraceutical candidates for curative cancer treatment abound. Discerning which constituents, which extraction method, and which delivery method to use for an efficacious treatment is an essential, lengthy process. If nutraceuticals such as limonene and Kahalalide F move forward to Phase III trials a nutraceutical cancer treatment pipeline may be established. Withaferin-A and derivatives for breast and ovarian cancer appear to be the leading gynecologic cancer nutraceutical drug candidates.

show abstract

“…Nigella sativa was the biblical and the prophet Mohammed's curative black cumin, Hippocrates and Doscorides' Melanthion [60,61]. Nigella sativa is also used in Ayurveda and TCM [61].…”

Section: Phenolsmentioning

confidence: 99%

Section: Phenolsmentioning

confidence: 99%

Section: Phenolsmentioning

confidence: 99%

Section: Phenolsmentioning

confidence: 99%

See 2 more Smart Citations

Nutraceuticals: Curative Integrative Cancer Treatment

Nwanodi¹

2017

Altern Integr Med

View full text Add to dashboard Cite

show abstract

“…Rhus coriaria exhibits anticancer activities (suppressing angiogenesis, metastasis and tumor growth) by promoting cell cycle arrest and autophagic cell death of the breast cancer cells [13,14] . N. sativa has long been recognised as antitumorigenic effects especially on hard splenic masses [15] . It has been exclusively used for a wide range of tumors.…”

Section: Introductionmentioning

confidence: 99%

Farelerde AK27 Bitkisel Karışımının Ehrlich Ascites Karsinoma Üzerine Antitümorijenik Etkisi

Demirkan¹,

Ertekın²,

Korkmaz³

et al. 2017

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

Citation of This ArticleDemirkan İ, Ertekin T, Korkmaz M, Kılıç İ, Çevik-Demirkan A, Bozkurt F, Konuktürk A: Antitumorigenic activity of the herbal mixture-AK27 on ehrlich ascites carcinoma in mice. Kafkas Univ Vet Fak Derg, 23 (5): 817-823, 2017817-823, . DOI: 10.9775/kvfd.2017 AbstractThe treatment of cancer is highly challenging and contains surgery, chemotherapy and radiotherapy alone or combinations which have various side effects on the patient health. This study aimed at observing the possible antineoplastic activity of AK27-herbal mixture, a combination of pistachio resin, rhus resin, pollen, Nigella sativa seed, pomegranate skin and olive oil, on experimentally induced Ehrlich ascites carcinoma (EAC) in a mouse model. EAC-bearing mice were evaluated by tumor cell count (viable and non-viable), median survival time, percentage increase in the life span and live body weight changes up to 30 days of EAC inoculation. Volume of EAC cells and viable cell count were found to be significantly decreased in AK27 treated groups when compared to EAC control group (P<0.01). The highest viable cell count (mean 15.5x10 7 /mL/mouse) and EAC volume (average 12 mL/mouse) was measured in the cancer group. Administration of AK27 mixture before tumor challenge prevented the EAC development whereas simultaneous administration or after tumor initiation, AK27 significantly reduced the number of viable EAC cells with respect to cancer control group. After the 4th day onwards until the 12th day significant differences were observed between groups in terms of live body weight (P<0.001). All animals in cancer control group died within 12 days as expected. Mean life span in AK27 treated groups were varied from 24 to 26 days with percentage increase in life span of from 100 to 150. The present study demonstrated that AK27-compound was exhibited promising antitumor efficacy in EAC bearing mice. Keywords: Ehrlich ascites carcinoma, Pistachio, Rhus, Nigella sativa, Pollen, Olive oil Farelerde AK27 Bitkisel Karışımının Ehrlich Ascites Karsinoma Üzerine Antitümorijenik Etkisi ÖzetKanser sağaltımı oldukça zor ve hastanın sağlığı üzerine olumsuz etkileri olan cerrahi, kemoterapi ve radyoterapinin tek başına veya kombinasyonlarını kapsar. Bu çalışmanın amacı antep fıstığı reçinesi, sumak reçinesi, polen, çörek otu tohumu, nar kabuğu ve zeytinyağı kombinasyonundan oluşan AK27-bitkisel karışımın muhtemel antineoplaistik etkinliğini fare modelinde deneysel oluşturulan Ehrlich asites karsinomunda (EAK) göstermektir. EAK'lı fareler tümör hücre sayısı (canlı ve ölü), ortalama yaşam süresi, yaşam süresinde yüzde artış ve canlı ağırlık değişimi yönünden değerlendirildi. En yüksek canlı hücre sayısı (ortalama 15.5x10 7 /mL/fare) ve EAK hacmi (ortalama 12 mL/ fare) kanser grubunda ölçüldü. AK27 karışımının tümör oluşturulmasından önce verilmesi EAK gelişimini engellerken aynı anda veya tümör oluştuktan sonra verilmesi kanser kontrol grubu ile karşılaştırıldığında canlı EAK hücre sayısını anlamlı düzeyde azalttığı gözlendi. Dördüncü günden itibaren ...

show abstract

Anticancer effects of thymoquinone in head and neck squamous cell carcinoma: A scoping review

Kwan,

Han,

Mukdad

et al. 2023

Laryngoscope Investig Oto

View full text Add to dashboard Cite

ObjectiveThymoquinone (TQ), the active constituent of Nigella sativa, has been shown to have anticancer effects in head and neck squamous cell carcinoma (HNSCC). This review aims to outline the properties of TQ, the known drivers in HNSCC formation, and summarize the anticancer effects of TQ in SCC.Data SourcesThree databases (PubMed, Embase, and Google Scholar) were queried for the key words “thymoquinone squamous cell carcinoma.”Review MethodsPublications that were not original research and publications that did not have full‐text available for review were excluded.ResultsSixteen research articles met the inclusion criteria. Our review demonstrates that TQ‐induced cytotoxicity is associated with increased expression and activity of the tumor suppressor p53, proapoptotic proteins Bax and caspases, as well as decreased expression and activity of antiapoptotic proteins Bcl‐2 and Mdm2. Additionally, TQ modulates cell‐survival pathways such as the PI3k/Akt pathway. TQ synergizes with therapeutics including cisplatin and radiation. Early TQ administration may prevent carcinogenesis via upregulation of antioxidant enzymes, and TQ administration in the presence of cancer can result in disease mitigation via induction of oxidative stress.ConclusionTQ acts as an upregulator of proapoptotic pathways and downregulator of antiapoptotic pathways, modulates the oxidative stress balance in tumor development, and works synergistically alongside other chemotherapeutics to increase cytotoxicity. TQ has the potential to prevent carcinogenesis in patients who are at high‐risk for SCC and adjuvant treatment for SCC patients undergoing conventional treatments. Future studies should aim to identify specific populations in which TQ's effects would be the most beneficial.Level of EvidenceNot available.

show abstract

Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular Pathways

Cited by 96 publications

References 125 publications

Nutraceuticals: Curative Integrative Cancer Treatment

Nutraceuticals: Curative Integrative Cancer Treatment

Farelerde AK27 Bitkisel Karışımının Ehrlich Ascites Karsinoma Üzerine Antitümorijenik Etkisi

Anticancer effects of thymoquinone in head and neck squamous cell carcinoma: A scoping review

Contact Info

Product

Resources

About