Therapeutic Nanodevices

Lee, Stephen C.; Ruegsegger, Mark; Barnes, Philip D.; Smith, Bryan; Ferrari, Mauro

doi:10.1007/978-3-662-40019-7_10

Cited by 5 publications

(4 citation statements)

References 79 publications

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“…Their properties emerge as the result of the spatial and/or temporal organization, coordination and regulation of action of individual components [13]. Their properties emerge as the result of the spatial and/or temporal organization, coordination and regulation of action of individual components [13].…”

Section: Cellular Internalization and Drug Targetingmentioning

confidence: 99%

Nanotechnology for Delivery of Drugs and Biomedical Applications

Leucuţa

2010

CCP

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Nanotechnology is a multidisciplinary scientific field that deals with the formulation, preparation, characterization and application of structures, devices and systems at nanometric scale. Area of concern is interdisciplinary, but with peculiarities, among others, medicine, pharmacy, biophysics, electronics, bioengineering, and molecular biology. Interest for modern nanotechnology lies in the creation and use of structures which have new properties because of their small size as well as the possibility of using these systems to control or manipulate biological structures at nanometric or atomic level. It will open the way to diagnosis and medical treatment to molecular level. This paper covers various fundamental and applied aspects of nanotechnology, in its chapters: introduction; nanoparticles (therapeutic polymers, polymeric nanoparticles, non-polymeric nanoparticles, liposomes, nanodevices) nanopharmaceutical systems used in diagnosis and therapy, in tissue engineering; pharmacokinetics and toxicity of nanoparticulate systems. Nanoparticulate systems have the potential to constitute a new generation of drug delivery systems. By their nature, nanodevices can be used as innovative diagnostic tool for detecting and monitoring disease, also for its treatment and use in developing new drugs.

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Section: Cellular Internalization and Drug Targetingmentioning

confidence: 99%

Nanotechnology for Delivery of Drugs and Biomedical Applications

Leucuţa

2010

CCP

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“…Silicon microfabrication technology can permit the creation of drug delivery devices that possess a combination of structural, mechanical, and electronic features that may surmount some of these challenges [1,6].…”

Section: Introductionmentioning

confidence: 99%

Nanoengineered device for drug delivery application

et al. 2004

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A high precision nanoengineered device was developed to yield long term zero-order release of drugs for therapeutic applications. The device contains nanochannels that were fabricated in between two directly bonded silicon wafers and therefore poses high mechanical strength. The fabrication is based upon selectively growing oxide and then removing it, and thus defining nanochannels by consuming a specified layer of silicon during oxide growth. Diffusion through the nanochannels is the rate limiting step for the release of drugs. A measurement of glucose released through such nanochannels validates the zero-order release profile. Device design, fabrication details and the glucose release profile through 60 nm channels are presented.

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“…that cannot be duplicated by synthetic nanomaterials with current technology. The potential of proteins as prefabricated components of nanodevices is becoming increasingly accepted [1][2][3][4][5][6], and is greatly facilitated by the development of chemoselective conjugation developed from the field of chemical protein synthesis [7]. Chemoselective conjugation allows covalent bond formation between a polypeptide and heterologous materials to occur exclusively at one particular site on the polypeptide, generally at the N-terminal amine (but sometimes at other residues).…”

Section: Introductionmentioning

confidence: 99%

Screening Libraries of Circularly Permuted Proteins by Phage Display to Manipulate Protein Topographies

Eteshola

Valkenburgh

Merlin

et al. 2005

Proceedings of the Institution of Mechanical Engineers, Part N:

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Active biomolecules, particularly proteins, are increasingly used in functional nanostructures. For some applications, native proteins (i.e. proteins as they occur in nature) are not effective nanodevice components because distances between the ends of the protein and some protein functional domain exceeds some critical nanoscale distance. This problem occurs in sensing architectures that detect energy or electron transfer where native protein sizes exceed critical distances for quantum energy transfer or exceed the thickness of shielding layers of counter ions, and might be addressed by alterations of protein topography. This work describes a high-throughput recombinant DNA method rapidly to identify functional circularly permuted (cp) protein variants. When appended to a sensing device or other nanometer scale distance-dependent device using chemoselective conjugation methods, cp variants offer a potential strategy to address the nanometer size limitations of native proteins.

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Therapeutic Nanodevices

Cited by 5 publications

References 79 publications

Nanotechnology for Delivery of Drugs and Biomedical Applications

Nanotechnology for Delivery of Drugs and Biomedical Applications

Nanoengineered device for drug delivery application

Screening Libraries of Circularly Permuted Proteins by Phage Display to Manipulate Protein Topographies

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