2023
DOI: 10.1016/j.cclet.2022.107953
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Therapeutic poly(amino acid)s as drug carriers for cancer therapy

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Cited by 17 publications
(16 citation statements)
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“…37 In addition, some candidate materials related to the structure–property relationship of polymers are gradually being applied in the treatment of prostate cancer, 38 polyamino acids have functions such as immune regulation, anti-inflammatory and antioxidant activities, and promotion of cell apoptosis, and are often used as drug carriers to promote effective cancer treatment. 39 In addition, materials for some new forms of cell death have also begun to be developed, such as nanomaterials that induce immunogenic cell death. 40 Furthermore, the particles contain enclosed drugs, guaranteeing that the pharmaceutical characteristics of the drugs do not interfere with the dispersion of the nanoparticles themselves.…”
Section: Discussionmentioning
confidence: 99%
“…37 In addition, some candidate materials related to the structure–property relationship of polymers are gradually being applied in the treatment of prostate cancer, 38 polyamino acids have functions such as immune regulation, anti-inflammatory and antioxidant activities, and promotion of cell apoptosis, and are often used as drug carriers to promote effective cancer treatment. 39 In addition, materials for some new forms of cell death have also begun to be developed, such as nanomaterials that induce immunogenic cell death. 40 Furthermore, the particles contain enclosed drugs, guaranteeing that the pharmaceutical characteristics of the drugs do not interfere with the dispersion of the nanoparticles themselves.…”
Section: Discussionmentioning
confidence: 99%
“…Chemical shifts were reported in ppm. 1 H NMR was employed to confirm the structure of the products and detect changes in chemical shifts.…”
Section: Instruments and Methodsmentioning
confidence: 99%
“…Although significant advances have been made in the field of cancer treatment in recent years, traditional cancer treatment methods are still insufficient to effectively target cancer cells and avoid damaging healthy tissues. [1] Recently, a wide variety of nanoplatforms have been developed that show good biocompatibility, high drug loading capacity, controlled drug release ability, as well as enhanced tumor penetration ability. [2] To address this challenge, targeted drug delivery approaches offer a promising solution.…”
Section: Introductionmentioning
confidence: 99%
“…BBB penetration by Au complexes remains a challenge for applications in glioma, but recent studies have shown success by targeting endogenous receptor-mediated transport systems. Lactoferrin (LF) receptors (LFRs) are overexpressed in glioma cells and on brain endothelial cells (ECs), where they mediate LF delivery into the brain. Nanomedicine drug delivery systems promote drug dissolution and improve absorption and targeting for cancer therapy. LF NPs enable drugs to cross the BBB and are characterized by high biocompatibility, biodegradability, and tolerance in vivo . Therefore, Au thiosemicarbazone complexes may be effective antitumor agents to treat glioma, particularly when combined with the unique properties of LF NPs for transit across the BBB. We hypothesized that nanoparticles prepared with LF matrix and encapsulated Au complex would efficiently cross the BBB and provide targeted delivery of Au complex to the glioma.…”
Section: Introductionmentioning
confidence: 99%