Therapeutic potential of octyl gallate isolated from fruits of<i>Terminalia bellerica</i>in streptozotocin-induced diabetic rats

Latha, R; Daisy, P.

doi:10.3109/13880209.2013.766894

Cited by 30 publications

(18 citation statements)

References 32 publications

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“…However, at lower doses the effects of n-octyl gallate may not be necessarily harmful. n-Octyl gallate is able to lower blood sugar levels in diabetic rats [5], justifying the suggestion that this compound could be the antihyperglycemic principal part of T. bellerica. In addition, n-octyl gallate changed the levels of several plasma constituents including an increase in the circulating insulin levels.…”

Section: Discussionmentioning

confidence: 93%

“…In green tea, for example, the gallic acid moiety is one of the most common structures among its phenolic compounds, free gallic acid, and n ‐propyl gallate being particularly abundant . Methyl gallate and others are constituents of wine , and n ‐octyl gallate has been found in the medicinal plant Terminalia bellerica . Because of their antioxidant properties, several alkyl gallates, including n ‐propyl gallate and n ‐octyl gallate, have been added to foods (especially oils and fats), cosmetics, hair products, adhesives, and lubricants to prevent oxidation .…”

Section: Introductionmentioning

confidence: 99%

“…Since hydrophobic structures are involved in transport phenomena, it seems reasonable to hypothesize that alkyl gallates with longer side chains than n ‐propyl gallate (e.g., as n ‐octyl gallate) should be more effective as inhibitors of pyruvate carboxylation than those with shorter side chains (e.g., methyl gallate). This question is especially important for n ‐octyl gallate because this compound, as a constituent of T. bellerica , has been claimed to be the antihyperglycemic principal part of this plant as it is in fact able to decrease the blood glucose levels in streptozotocin diabetic rats . In this regard, gluconeogenesis inhibition can also contribute to lowering blood sugar levels and, under extreme conditions, generate a situation that is harmful for the whole organism.…”

Section: Introductionmentioning

confidence: 99%

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n‐Octyl Gallate as Inhibitor of Pyruvate Carboxylation and Lactate Gluconeogenesis

Eler

Santos

Moraes

et al. 2014

J Biochem & Molecular Tox

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The alkyl gallates are found in several natural and industrial products. In the latter products, these compounds are added mainly for preventing oxidation. In the present work, the potencies of methyl gallate, n-propyl gallate, n-pentyl gallate, and n-octyl gallate as inhibitors of pyruvate carboxylation and lactate gluconeogenesis were evaluated. Experiments were done with isolated mitochondria and the isolated perfused rat liver. The potency of the gallic acid esters as inhibitors of pyruvate carboxylation in isolated mitochondria obeyed the following decreasing sequence: n-octyl gallate > n-pentyl gallate > n-propyl gallate > methyl gallate. A similar sequence of decreasing potency for lactate gluconeogenesis inhibition in the perfused liver was found in terms of the portal venous concentration. Both actions correlate with the lipophilicity of the compounds. The effects are harmful at high concentrations. At appropriate concentrations, however, octyl gallate should act therapeutically because its inhibitory action on gluconeogenesis will contribute further to its proposed antihyperglycemic effects.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

n‐Octyl Gallate as Inhibitor of Pyruvate Carboxylation and Lactate Gluconeogenesis

Eler

Santos

Moraes

et al. 2014

J Biochem & Molecular Tox

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“…Where data are available, there is moderate evidence of endocrine disruption (a Group I end point) for many of these compounds. 104,110,111,120 There is also moderate evidence of skin sensitization, skin irritation, and/or eye irritation for most benzoate esters, based on both authoritative lists and computations. These hazard end points are of particular concern in home and personal care products, but are also of concern for workers who handle building materials or food packaging.…”

Section: Acs Sustainable Chemistry and Engineeringmentioning

confidence: 99%

Design and Testing of Safer, More Effective Preservatives for Consumer Products

Buckley

Hart‐Cooper

Kim

et al. 2017

ACS Sustainable Chem. Eng.

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Preservatives deter microbial growth, providing crucial functions of safety and durability in composite materials, formulated products, and food packaging. Concern for human health and the environmental impact of some preservatives has led to regulatory restrictions and public pressure to remove individual classes of compounds, such as parabens and chromated copper arsenate, from consumer products. Bans do not address the need for safe, effective alternative preservatives, which are critical for both product performance (including lifespan and therefore life cycle metrics) and consumer safety. In this work, we studied both the safety and efficacy of a series of phenolic preservatives and compared them to common preservatives found in personal care products and building materials. We quantified antimicrobial activity against Aspergillus brasiliensis (mold) and Pseudomonas aeruginosa (Gram negative bacteria), and we conducted a hazard assessment, complemented by computational modeling, to evaluate the human and environmental health impacts of these chemicals. We found that octyl gallate demonstrates better antimicrobial activity and comparable or lower hazards, compared to current-use preservatives. Therefore, octyl gallate may serve as a viable small-molecule preservative, particularly in conjunction with low concentrations of other preservatives that act through complementary mechanisms.

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“…Antilipidemic drug in diabetes is effective in reducing the risk of cardiovascular disease [3]. Recently, the search for appropriate hypoglycemic agents has been focused on plants used in traditional medicine [4]. Identification of natural products and its molecular mechanism by which it improves diabetic complications may open the new therapeutic target for the treatment of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity

Thomas

Sankar

Bobby

2013

JCDR

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Background: S-methyl L-cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in Alium plants such as, garlic and onion.Objectives: The present study was aimed to evaluate the hypoglycemic and antihyperlipidemic properties of SMC in high fructose induced diabetic rats. Material and Methods:The present study was designed to evaluate the hypoglycemic and antihyperlipidemic properties of SMC in high fructose induced diabetic rats. Blood samples were collected and the fasting plasma glucose, lipid profile, total antioxidant status (TAS) aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were estimated using standard procedures. Differences between the groups were assessed by using One way Analysis of Variance with (ANOVA) Tukey post hoc test.Results: Oral administration of SMC at a dose of 100 mg/kg bodyweight/day to HFD-treated rats for a period of 60 days showed significant reduction in the animal weight, fasting plasma glucose, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), VLDL-C and elevation in the level of high-density lipoprotein cholesterol (HDL-C) and TAS compared with fructose fed group. The effects of SMC was compared with metformin; a well-known antihyperglycemic drug. Conclusion:In conclusion, SMC found to be effective in improving the high fructose induced hyperglycemia and dyslipidemia. It may possibly provide a potential adjuvant for the treatment and management of diabetes.

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Therapeutic potential of octyl gallate isolated from fruits ofTerminalia bellericain streptozotocin-induced diabetic rats

Cited by 30 publications

References 32 publications

n‐Octyl Gallate as Inhibitor of Pyruvate Carboxylation and Lactate Gluconeogenesis

n‐Octyl Gallate as Inhibitor of Pyruvate Carboxylation and Lactate Gluconeogenesis

Design and Testing of Safer, More Effective Preservatives for Consumer Products

Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity

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