Therapeutic Potential of Probiotics and Prebiotics

Abstract

Advancement in technology is continued as the time is passed. The biological active ingredients technology is the challenging issues for both the researchers and manufacturers. In last decade, much research has been happened about the potential health benefits of pro and prebiotic ingredients. Probiotics are the live microorganisms when given in adequate amount confer health benefits but the prebiotics are indigestible ingredients that enhance the activity of one or more probiotics in the colon. The therapeutic potential of these two biological active ingredients is the outcome of emerging field of biotechnology. A number of studies indicating therapeutic potential of probiotics regarding gastrointestinal health, cancer, constipation, immunomodulation, Helicobacter pylori, liver disease and urogenital infection have been documented. Similarly, prebiotics also improved helpful for many communicable and non-communicable diseases. It can be seen that advancement in the biotechnology field offer great choice to deliver a marvelous health advantages. Although the market for probiotic and prebiotic food and supplements has been increased in this new era but still need to develop food and supplements containing these two active ingredients with the cooperation of legal bodies of the country.

The Effect of Probiotic in Milk Fermentation Towards Decreasing Cholesterol Levels: in Vivo Studies

“…Probiotics are drinks containing probiotic bacteria which has health effects due to the fermentation process. Probiotics can be used as antihypercholesterolemia therapy since probiotic bacteria can increase the secretion of Bile Salt Hydrolase (BSH) enzyme which then enable the increasing excretion of bile acids (Naim, 2011;Gulzar et al, 2019). Apart from that, probiotic bacteria produce cholesterol dehydrogenase cofactor which functions to activate the cholesterol reductase enzyme, converting cholesterol into cosprotanol.…”

Structured soft particulate matters for delivery of bioactive compounds in foods and functioning in the colon

“…9,18 Probiotics, prebiotics, and synbiotics are therefore studied to enhance human health. [7][8][9] 2.2. Colorectal cancer CRC ranks the third in the prevalence of most common cancers, 20 and the probability of suffering this cancer is about 4%-5%.…”

“…6 GM can be manipulated by supplementing live beneficial microorganisms, i.e., probiotics, compounds facilitating the growth and activity of probiotics, i.e., prebiotics, or ''a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host,'' i.e., synbiotics. [7][8][9] Dietary fibres are not digestible in the gastrointestinal (GI) tract and not directly bioactive. 3 However, dietary fibres, especially soluble ones, can be fermented by GM in the colon, and the metabolites contribute to gut health.…”

Plant Prebiotics and Their Role in the Amelioration of Diseases

“…Furthermore, in Crohn’s disease (CD), a type of IBD, it was evaluated that the incidence of a misbalance in gut microbiota was high when F. prausnitzii was observed [ 237 ]. Prebiotics have been used to control the adverse effects in CD patients [ 238 ]. A study reported a decline in the number of Bacteroides in the fecal matter of CD patients when they received inulin at 24 g/day [ 239 ].…”