Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats

Abstract

The current study was aimed to analyze the therapeutic effect of selected medicinal plants, that is, Curcuma longa, Zingiber officinale, Trigonella graceum-foenum, Nigella sativa, and Syzygium aromaticum against carrageenan-induced oxidative stress and inflammation in rats. Phytochemical analysis revealed the presence of diverse range of bioactives. IC50 values for antioxidant assays including DPPH (2,2-diphenyl-1-picrylhydrazyl), metal chelating, ABTS scavenging (2, 2′-Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic Acid), β-carotene bleaching, and H2O2 (hydrogen peroxide) scavenging ranged from 37-294, 71-243.4, 69.66-191.8, 98.92-228.5, and 82-234.9 μg/mL, respectively. All tested plants extract were found active against tested pathogenic microorganisms with lowest minimum inhibitory concentrations. Oral administration of tested plants extracts in different doses (250, 500, and 1000 mg/kg b. w) did not exhibit any toxicological effects on hemato-biochemical profile of treated rats in comparison to control group rats. Further, plants extract exhibited considerable anti-inflammatory activity in rats paw inflammation and decreased cellular infiltration to inflammatory site in dose dependent manner. Pretreatment of animals with tested plants extract (100, 200, and 400 mg/kg b. w.) caused significant alteration in total antioxidants, oxidants, and enzymes activities in paw tissue homogenate and the effect was more pronounced at higher concentration (400 mg/kg b. w.). Results showed that tested plants extract are rich source of diverse classes of phenolics and have therapeutic potential against oxidative stress and inflammation.

Metabolomic Analysis Reveals the Metabolic Diversity of Wild and Cultivated Stellaria Radix (Stellaria dichotoma L. var. lanceolata Bge.)

“…Habitat is an important factor affecting the quality of herbal medicinal materials. Different habitats will affect the formation and accumulation of secondary metabolites in the plants, thereby affecting the quality of medicinal products [ 10 , 11 ]. Therefore, the significant differences in the contents of total flavonoids and total sterols and the expression of the 53 metabolites that we found in this study might be the result of field management and habitat differences.…”

Phytobioactive compounds as therapeutic agents for human diseases: A review

“…Phytobioactives are also known as plant secondary metabolites and bioactive compounds (Fatima et al, 2021). They are present ubiquitously in the plant kingdom and are considered nonnutritional but vital components for the maintenance of human health (Nafees et al, 2017).…”

“…Phytobioactive compounds play a significant role in the adaptation of plants to their surrounding environment but are also a major source for the pharmaceutical industry (Merrouni & Elachouri, 2021 ). Phytobioactives are also known as plant secondary metabolites and bioactive compounds (Fatima et al, 2021 ). They are present ubiquitously in the plant kingdom and are considered nonnutritional but vital components for the maintenance of human health (Nafees et al, 2017 ).…”

Investigation of the Antinociceptive Activity of the Hydroethanolic Extract of Junglas nigra Leaf by the Tail-Immersion and Formalin Pain Tests in Rats

“… 5 , 6 An antiinflammatory effect of the extract of J. nigra leaf has been reported in some animal models of acute and chronic inflammation, such as carrageenan-induced mice hind paw edema, 15 xylene-induced mice ear edema, 16 and cotton pellet-induced granuloma tests in mice. 17 Also, it was shown that the extract reduced nociception in models of acute pain in mice, such as the hot-plate and the writhing tests, 15 , 16 but the effect of the extract has not been investigated in other models of pain.…”

“…Acute inflammation is associated with increased production of reactive oxygen and nitrogen species, inflammatory mediators, and the activation of enzymes. 17 , 18 Pain is commonly associated with inflammation, which is the consequence of tissue damage, chemical stimuli, and foreign substances. After tissue injury, nitroxidant dysregulation in the cell promotes the development of inflammation and central sensitization, crucial for the onset of chronic neuropathic or inflammatory pain.…”