Therapeutic Potentials of Phytochemicals Against<i>Mycobacterium tuberculosis</i>, the Causative Agent of Tuberculosis

Ogodo, Alloysius Chibuike; Tatah, Verwiyeh Silas; Ebuara, Francis Ushie; Ogodo, Chidera Favour

doi:10.1002/9781119617143.ch22

Cited by 3 publications

(1 citation statement)

References 78 publications

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“…Mycobacterium tuberculosis ( Mtb ), an intracellular pathogen that causes tuberculosis (TB), continues to be a global public health concern. 1 According to the latest report from the World Health Organization (WHO), approximately 10.6 million people received a TB diagnosis in 2021, an increase of 4.5% from 2020, and 1.6 million people died of the disease (including 187,000 HIV-positive individuals). 2 The highest percentage of TB cases was found in the WHO regions of Southeast Asia (44%), Africa (25%), and the Western Pacific (18%).…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium tuberculosis Biofilms: Immune Responses, Role in TB Pathology, and Potential Treatment

Assefa,

Girmay

2024

ITT

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Section: Introductionmentioning

confidence: 99%

Mycobacterium tuberculosis Biofilms: Immune Responses, Role in TB Pathology, and Potential Treatment

Assefa,

Girmay

2024

ITT

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Antimycobacterial, antibiofilm and efflux pump inhibitory activity of extracts from selected Combretum species used in traditional medicine in Zimbabwe

Chikafa,

Fru,

Mukanganyama

2023

ADV TRADIT MED (ADTM)

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Multifunctional analysis and antimicrobial activity of Adhatoda vasica: a traditional medicinal plant

Fatima,

Zafar,

Ain

et al. 2023

Drug Metabolism and Personalized Therapy

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Objectives Antibiotic resistance is rising, prompting innovative strategies for eradicating the epidemic. This study investigated the antibacterial properties of the leaves of a widely used medicinal plant, Adhatoda vasica. Methods The plant’s polar (water, methanol) and non-polar (hexane) extracts were tested against several different bacterial strains using the disc diffusion technique. Results In a study, it was found that the water extract had the greatest inhibitory effect on Staphylococcus simulans and Staphylococcus aureus, with minimum inhibitory concentrations of 16.444 and 19.315 g/mL, respectively. Gram-negative strains were more susceptible to plant extracts than Gram-positive strains. The phytochemical analysis indicated the presence of secondary metabolites such as alkaloids, saponins, flavonoids, tannins, and steroids, where absorbance was recorded at 415 nm. The water extract had the highest amount of phenolics, with a total phenolic content of 53.92 0.47 mg and a total flavonoid content of 7.25 0.08 mg. Results suggest that the extract may have potential therapeutic applications for antimicrobial properties. Conclusions The study concluded that the extract’s phenolic group of secondary metabolites were responsible for its antibacterial activity. The study highlights A. vasica as a promising source for discovering new and effective antibacterial compounds.

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Therapeutic Potentials of Phytochemicals AgainstMycobacterium tuberculosis, the Causative Agent of Tuberculosis

Cited by 3 publications

References 78 publications

Mycobacterium tuberculosis Biofilms: Immune Responses, Role in TB Pathology, and Potential Treatment

Mycobacterium tuberculosis Biofilms: Immune Responses, Role in TB Pathology, and Potential Treatment

Antimycobacterial, antibiofilm and efflux pump inhibitory activity of extracts from selected Combretum species used in traditional medicine in Zimbabwe

Multifunctional analysis and antimicrobial activity of Adhatoda vasica: a traditional medicinal plant

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