Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs

Mumtaz, Shumaila; Ali, Shaukat; Khan, Rizwan Taj; Shakir, Hafiz Abdullah; Tahir, Hafız Muhammad; Mumtaz, Samiara; Andleeb, Saiqa

doi:10.1007/s11356-020-07654-2

Cited by 42 publications

(29 citation statements)

References 57 publications

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“…53 Besides, VE is a non-enzymatic defense system in testicular mitochondria. 16 This vitamin can inhibit oxidative damage in the testis 16,49 and prevents the apoptosis induction in spermatogenic, Sertoli, and Leydig cells 18 which, it plays an important role in their count, as well as, sperm viability. 22,49 Additionally, VE can return glutathione to its normal levels on the system intracellular free radical scavenging and reduces the oxidative stress levels.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effect of Vitamin E on the male rat reproductive system by a high oral dose of Bisphenol-A

Malmir

Mehranjani

Faraji

et al. 2021

Toxicology Research and Application

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Among researchers, environmental pollutants and their contribution to male fertility are still being discussed. The use of antioxidants manages to boost the reproductive system with the scavenging of free radicals. This study aimed to investigate the inhibiting function of Vitamin E (VE) on Bisphenol-A (BPA) toxicity in the male rats’ reproductive system. Male rats were divided into 4 groups: control (negative control) group, BPA group treated by 250 mg/kg/day (positive control), VE group treated by 150 mg/kg/day (comparative control) and BPA + VE group that received both doses at the same time (Oral treatment by gavage; 56 days). Sperm parameters, testicular tissue morphometric and biochemical tests were evaluated. Sperm count, motility, viability, normal morphology, sperm tail length, spermatogenesis index and serum testosterone levels significantly decreased in the BPA group compared to the control group. Versus a significant enhancement in the positive-TUNEL germinal cells and serum malondialdehyde (MDA) levels were observed. Moreover, BPA exhibited no effect on sperm maturity and DNA integrity. In the simultaneous treatment group (BPA + EV), VE could improve and regulate all the mentioned parameters within the control group range. As mentioned, there was a significant difference in the results in the positive control group compared to the negative control group. But these data improved significantly in the BPA + VE. It can be concluded that in this group, VE was able to overcome the toxicity caused by positive control in their simultaneous treatment and maintain the data at the negative control group range. Therefore, no significant change was observed in the BPA + VE group compared to the negative control group.

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Section: Discussionmentioning

confidence: 99%

Antioxidant effect of Vitamin E on the male rat reproductive system by a high oral dose of Bisphenol-A

Malmir

Mehranjani

Faraji

et al. 2021

Toxicology Research and Application

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“…In addition, the protective effects of vitamins C on the liver, kidneys, brain, and testes against oxidative damage caused by exposure to Pb have been well demonstrated [18][19][20]. Vitamin C exerted nonenzymatic antioxidant function by destroying free radicals and trapping them in the aqueous phase to protect the biological membrane [21,22]. However, there is a report that high doses of vitamin C have been suggested to cause oxidative stress and cell death [23].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Nano-Vitamin C on Infertility due to Oxidative Stress Induced by Lead and Arsenic in Male Rats

Raeeszadeh

Karimfar

Amiri

et al. 2021

Journal of Chemistry

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Occupational and environmental exposure to heavy metals such as arsenic (As) and lead (Pb) by inducing oxidative damage may impair male fertility. However, there is a new view that shows that the nano form of vitamins such as vitamin C, which have antioxidant activity, can be effective in improving this disorder. Therefore, this study aimed to evaluate the effect of NVC (NVC) on reproductive toxicity caused by the combination of Pb and As on testicular histology, sperm morphology, oxidative stress parameters, and hormonal changes in male rats. In this experimental study, forty-two male Wistar rats were randomly divided into six groups: control, NVC (200 mg/kg), As (50 ppm sodium arsenate), Pb (500 ppm Pb acetate), As + NVC, and Pb + NVC. FSH, LH, and testosterone levels were measured in serum. The activity of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), carbonyl protein, malondialdehyde (MDA), and total antioxidant capacity (TAC) was measured in testis. Histological examination and sperm parameters were also evaluated. FSH, LH, and testosterone levels and sperm parameters significantly decreased, and levels of protein carbonyl, MDA, and DNA fragmentation increased in the As and Pb groups, while treatment with NVC could improve them. Histological evaluation and sperm parameters in As and Pb groups showed damage in the process of spermatogenesis and sperm parameters. The treatment with NVC could significantly improve these parameters. The activity of GPx, SOD, and CAT in testis decreased in As and Pb groups, while treatment with NVC could enhance them. It can be concluded that NVC by inhibiting oxidative damage and improving serum level of testosterone, LH, and FSH could overcome As- and Pb-induced reproductive dysfunction.

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“…On the other hand, our data detected that propolis treatment after oral mixture metals exposure, afforded semi-normal recovering from many complications arose by metals effects; where signi cant reduction in the concentrations of all investigated metals was observed and con rmed statistically among liver tissues (p < 0.001) and kidney (p < 0.01) except cadmium which reduced without statistically signi cance. The depletion of lead, nickel, cadmium and antimony in the propolis treated group may be due to the antioxidant property of propolis that able to decrease the oxidative stress, inhibits progressive uctuations convinced through metals mixture, repaired alterations rising in the liver and kidney close to healthy measurements (Mumtaz et al, 2020). Propolis can scavenge reactive oxygen and nitrogen species, prevents lipid peroxidation, upregulates biosynthesis of various cytoprotective and antioxidant proteins, and has an inhibitory effect on the in ammatory cytokines (Gupta et al, 2011;Alghasham et al, 2013;Hosseini and Hosseinzadeh 2018).…”

Section: -1-toxic Metals and Propolismentioning

confidence: 98%

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

El-Amawy

Zaahkouk

Rasheed

et al. 2021

Preprint

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The study was designed to clarify the hepato-renal protective effects of propolis extract against heavy metals-induced toxicity via oral administration to the males of albino rats. Lead (Pb), Nickel (Ni), Cadmium (Cd), and Antimony (Sb) are toxic heavy metals have the ability to produce reactive radicals in the biological systems causing public and animals health hazards through disrupting balances between pro-oxidant and antioxidant defense system, resulting in excessive reactive oxygen species (ROS) production. The most commonly affected organs are liver and kidney. Propolis is a natural product with different shapes and resinous substance collected by honey bees, it attenuates many diseases damage due to its anti-oxidative action and its potentiality to minimize the deleterious effects of free radicals on tissues. The concentrations of Pb, Cd, Ni and Sb as well as the activities of antioxidants endogenous enzymes including; glutathione peroxidase (Gpx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) were all determined in the tissues of liver and kidney; while aspartate transaminase (ASAT), alanine transaminase (ALAT), total protein (TP), urea and createnine, were measured in the serum of experimental rats beside histopathologicl examination in the tissues of liver and kidney. The oral administration of propolis provided a significantly therapeutic role against multi-metals-induced hepato-renal toxicity with relative improving to histopathological changes because of its scavenging and chelating properties as concluded from the present investigation.

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Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs

Cited by 42 publications

References 57 publications

Antioxidant effect of Vitamin E on the male rat reproductive system by a high oral dose of Bisphenol-A

Antioxidant effect of Vitamin E on the male rat reproductive system by a high oral dose of Bisphenol-A

Protective Effect of Nano-Vitamin C on Infertility due to Oxidative Stress Induced by Lead and Arsenic in Male Rats

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

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