Therapeutic Role of Resveratrol and Piceatannol in Disease Prevention

Kukreja, Aayush; Wadhwa, Neha; Tiwari, Archana

doi:10.4172/2155-9864.1000240

Cited by 46 publications

(36 citation statements)

References 45 publications

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“…PIC is an important naturally occurring polyphenolic stilbene, produced by plants in response to fungal infection, mechanical damage and ultra-violet irradiation. It can be consumed on a daily basis with no harmful effects on human body [12]. PIC is known as a potent scavenger of free radicals due to hydroxyl groups in its stilbene rings [13].…”

Section: Introductionmentioning

confidence: 99%

Piceatannol Ameliorates Cisplatin-Induced Histological and Biochemical Alterations in Rats Kidney

Wahdan

Azab

Elsherbiny

et al. 2017

Int J Pharm Pharm Sci

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Objective: The present study was designed to investigate the effect of different doses of piceatannol (PIC) on cisplatin-induced biochemical and histological alterations in rat kidney. Methods:Male Wistar rats received a single intraperitoneal (i. p.) injection of cisplatin (7 mg/kg). PIC was given in different daily doses (5, 10 and 20 mg/kg) i. p., for seven days, starting two days before cisplatin injection. Nephrotoxicity was evaluated by means of measurement of blood urea nitrogen (BUN), serum creatinine and histopathological examination of the kidney. We also investigated the antioxidant effect of the most effective dose of PIC by measuring reduced glutathione (GSH) and lipid peroxides levels. Moreover, the ability of PIC to affect nuclear factor kappa B (NF-kB) expression was determined by immunohistochemical analysis. Results:A single dose of cisplatin (7 mg/kg) significantly increased BUN and creatinine levels, as well as relative kidney weight, compared to the control group. In addition, significant histopathological alterations including tubular necrosis, hemorrhage and casts formation were observed. PIC was given in different doses (5, 10 and 20 mg/kg) for 7 d, starting 2 d before cisplatin injection. PIC dose 10 mg/kg was the most effective in preventing these alterations. PIC significantly increased GSH level and decreased lipids peroxidation compared to cisplatin group. Moreover, PIC significantly mitigated cisplatin-induced expression of NF-kB.Conclusion: PIC has the potential to ameliorate cisplatin-induced renal injury.

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Section: Introductionmentioning

confidence: 99%

Piceatannol Ameliorates Cisplatin-Induced Histological and Biochemical Alterations in Rats Kidney

Wahdan

Azab

Elsherbiny

et al. 2017

Int J Pharm Pharm Sci

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“…Although low, the concentrations of t -Pt were more than 25-fold higher than those achieved in the control hairy roots. This biotechnological system thus proved to be suitable for the production of t -Pn and, on a lower scale, t -Pt, both compounds with promising biological activities and scarcely distributed in nature1.…”

Section: Discussionmentioning

confidence: 99%

“…A plethora of biological activities have been attributed to t -R, including inhibiting the progression of cardiovascular, carcinogenic, and neurodegenerative diseases as well as the ageing process, as confirmed by several in vitro assays1. However, the transfer of the beneficial biological properties of t -R from in vitro to in vivo systems is restricted by its limited oral bioavailability and rapid metabolism2.…”

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confidence: 99%

“…Indeed, part of the antitumoral effects of t -R are attributed to its conversion into t -Pn by specific cytochrome P450 hydroxylases, in particular CYP1B1, which over-expresses in a wide range of human tumors6. Scarcely distributed in nature, t -Pn occurs in plant species such as Passiflora edulis, Cassia marginata or Rhodomyrtus tomentosa , where its accumulation can be more than 1000-fold higher than in grape1. Its promising pharmacological activities have prompted a search for new sources of t -Pn, including biotechnological approaches.…”

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confidence: 99%

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Bioconversion of stilbenes in genetically engineered root and cell cultures of tobacco

Hidalgo

Martínez-Márquez

Moyano

et al. 2017

Sci Rep

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It is currently possible to transfer a biosynthetic pathway from a plant to another organism. This system has been exploited to transfer the metabolic richness of certain plant species to other plants or even to more simple metabolic organisms such as yeast or bacteria for the production of high added value plant compounds. Another application is to bioconvert substrates into scarcer or biologically more interesting compounds, such as piceatannol and pterostilbene. These two resveratrol-derived stilbenes, which have very promising pharmacological activities, are found in plants only in small amounts. By transferring the human cytochrome P450 hydroxylase 1B1 (HsCYP1B1) gene to tobacco hairy roots and cell cultures, we developed a system able to bioconvert exogenous t-resveratrol into piceatannol in quantities near to mg L−1. Similarly, after heterologous expression of resveratrol O-methyltransferase from Vitis vinifera (VvROMT) in tobacco hairy roots, the exogenous t-resveratrol was bioconverted into pterostilbene. We also observed that both bioconversions can take place in tobacco wild type hairy roots (pRiA4, without any transgene), showing that unspecific tobacco P450 hydroxylases and methyltransferases can perform the bioconversion of t-resveratrol to give the target compounds, albeit at a lower rate than transgenic roots.

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“…Piceatannol (8) is a natural phenol, produced naturally in various plants when the plant is attacked by pathogens such as bacteria or fungi. Resveratrol is metabolized in the body into piceatannol by the enzyme cytochrome P450 (Kukreja et al, 2014;Kim et al, 2009). …”

Section: Resveratrolmentioning

confidence: 99%

Natural product as a source of prodrug

Padmavathy¹,

Saravanan

2017

Bangladesh J Pharmacol

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<p class="Abstract">The natural products are the chemical constituents that are generated from the living organism. The natural products are isolated from the plants, animals, and microorganisms which are used in drug design and drug discovery. Natural product is then modified by chemical synthesis as either total or semi-synthetic way. The natural products show various pharmacological activity which can be used for the treatment of a variety of diseases. Natural products could be regarded as a source of quantifiable and chemically pure known products and also natural products can be utilized as complex mixtures subjected to chemical variability. The present review article adds up the prodrugs from natural products as well as prodrugs developed from the natural products.</p>

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Therapeutic Role of Resveratrol and Piceatannol in Disease Prevention

Cited by 46 publications

References 45 publications

Piceatannol Ameliorates Cisplatin-Induced Histological and Biochemical Alterations in Rats Kidney

Piceatannol Ameliorates Cisplatin-Induced Histological and Biochemical Alterations in Rats Kidney

Bioconversion of stilbenes in genetically engineered root and cell cultures of tobacco

Natural product as a source of prodrug

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