Therapeutic Strategies and Challenges in the Management of Craniospinal Tumors in Pregnancy: A Ten-Year Retrospective Tertiary-Center Study, Systematic Review, and Proposal of Treatment Algorithms

Ghimire, Prajwal; Pang, Graeme; Philip, Jerry; Hazem, Sally; Rajwani, Kapil; Lavrador, José Pedro; Grahovac, Gordan; Bleil, Cristina; Thomas, N.; Gullan, Richard; Vergani, Francesco; Bhangoo, Ranjeev; Ashkan, Keyoumars

doi:10.1016/j.wneu.2022.11.139

Cited by 3 publications

(2 citation statements)

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“…Primary malignant brain tumor in pregnant patients can be 2.6–15 per 100,000 [ 51 , 52 ]. Due to such low incidence, there are insufficient guidelines for the management of intracranial lesions during pregnancy [ 3 , 6 , 53 , 54 ], however; the significance of brain tumor in pregnant patients should not be underestimated. Various studies have discussed the neurological deterioration of patients with benign tumors such as low-grade-gliomas during pregnancy [ 12 ] which can be due to hormonal changes and increased peritumoral edema caused by fluid retention and increased intravascular volume during pregnancy [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Awake craniotomy during pregnancy: A systematic review of the published literature

Mofatteh,

Mashayekhi,

Arfaie

et al. 2023

Neurosurg Rev

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Neurosurgical pathologies in pregnancy pose significant complications for the patient and fetus, and physiological stressors during anesthesia and surgery may lead to maternal and fetal complications. Awake craniotomy (AC) can preserve neurological functions while reducing exposure to anesthetic medications. We reviewed the literature investigating AC during pregnancy. PubMed, Scopus, and Web of Science databases were searched from the inception to February 7th, 2023, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Studies in English investigating AC in pregnant patients were included in the final analysis. Nine studies composed of nine pregnant patients and ten fetuses (one twin-gestating patient) were included. Glioma was the most common pathology reported in six (66.7%) patients. The frontal lobe was the most involved region (4 cases, 44.4%), followed by the frontoparietal region (2 cases, 22.2%). The awake-awake-awake approach was the most common protocol in seven (77.8%) studies. The shortest operation time was two hours, whereas the longest one was eight hours and 29 min. The mean gestational age at diagnosis was 13.6 ± 6.5 (2—22) and 19.6 ± 6.9 (9—30) weeks at craniotomy. Seven (77.8%) studies employed intraoperative fetal heart rate monitoring. None of the AC procedures was converted to general anesthesia. Ten healthy babies were delivered from patients who underwent AC. In experienced hands, AC for resection of cranial lesions of eloquent areas in pregnant patients is safe and feasible and does not alter the pregnancy outcome.

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Section: Discussionmentioning

confidence: 99%

“…Intracranial pathologies during pregnancy pose a significant challenge to both the mother and fetus [ 1 – 3 ]. A predominance of central nervous system tumors, including gliomas, is observed in females older than 20 years of age, which coincides with the reproductive fertility and child-bearing period in life [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Awake craniotomy during pregnancy: A systematic review of the published literature

Mofatteh,

Mashayekhi,

Arfaie

et al. 2023

Neurosurg Rev

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Neurologic disease in the obstetric patient

Inozemtsev,

Yeh,

Nasr

2024

Current Opinion in Anaesthesiology

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Purpose of review Neurologic disorders and complications during pregnancy are common, but guidelines and data are sparse. This review aims to give an overview of recent developments in neuroanesthesia and management of neuropathology during pregnancy, with the hope that these may fill the gaps in current guidelines and recommendations, as well as their implications for an anesthetic approach. Recent findings Neuraxial and general anesthesia are safe in multiple sclerosis and myasthenia gravis, though neuromuscular blockade response is unpredictable and risk for exacerbation exists. Cerebral vascular pathology is common and carries a significant morbidity and mortality burden, but thrombolytic and endovascular therapies are often appropriate and safe. Instrumental vaginal delivery can minimize intracranial pressure shifts and is a viable option. Tumors and cerebral malformations require a complex multidisciplinary and anesthetic approach. Summary While clinical trials remain sparse, larger population-based studies offer insight into the optimal approach to the parturient with neurologic disease.

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Awake Craniotomy During Pregnancy: A Systematic Review of The Published Literature

Mofatteh

Mashayekhi

Arfaie

et al. 2023

Preprint

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Purpose Neurosurgical pathologies in pregnancy pose significant complications for the patient and fetus, and physiological stressors during anesthesia and surgery may lead to maternal and fetal complications. Awake craniotomy (AC) can preserve neurological functions while reducing exposure to anesthetic medications. We reviewed the literature investigating AC during pregnancy.Methods PubMed, Scopus, and Web of Science databases were searched from the inception to February 7th, 2023, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Studies in English investigating AC in pregnant patients were included in the final analysis.Results Nine studies composed of nine pregnant patients and ten fetuses (one twin-gestating patient) were included. Glioma was the most common pathology reported in six (66.7%) patients. The frontal lobe was the most involved region (4 cases, 44.4%), followed by the frontoparietal region (2 cases, 22.2%). The awake-awake-awake approach was the most common protocol in seven (77.8%) studies. The shortest operation time was two hours, whereas the longest one was eight hours and 29 minutes. The mean gestational age at diagnosis was 13.6 ± 6.5 (2–22) and 19.6 ± 6.9 (9–30) weeks at craniatomy. Seven (77.8%) studies employed intraoperative fetal heart rate monitoring. None of the AC procedures was converted to general anesthesia. Ten healthy babies were delivered from patients who underwent AC.Conclusions In experienced hands, AC for resection of cranial lesions in pregnant patients is safe and feasible and does not alter the pregnancy outcome.

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Therapeutic Strategies and Challenges in the Management of Craniospinal Tumors in Pregnancy: A Ten-Year Retrospective Tertiary-Center Study, Systematic Review, and Proposal of Treatment Algorithms

Cited by 3 publications

References 25 publications

Awake craniotomy during pregnancy: A systematic review of the published literature

Awake craniotomy during pregnancy: A systematic review of the published literature

Neurologic disease in the obstetric patient

Awake Craniotomy During Pregnancy: A Systematic Review of The Published Literature

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