Therapeutic strategies for prevention of postoperative recurrence in patients with Crohn's disease

Presence of Granulomas in Mesenteric Lymph Nodes Is Associated with Postoperative Recurrence in Crohnʼs Disease

“…7 The pathophysiology of recurrence is poorly understood. [8][9][10][11][12][13] The identification of risk factors for postoperative disease recurrence may help for decision-making, prevention, and early intervention. 5,7,10,11 Purported risk factors for postoperative recurrence include the young age at diagnosis, 6,14 smoking, 6,15,16 history of surgical resection, 6,17 genetic mutations, 6,18 perforating disease type, 6,19 extensive ileal resection, 2,20 disease location, 6,21 and short disease duration from the diagnosis to the first surgery.…”

Reply to Yamamoto

“…We thank Dr Yamamoto for his interest in our recent article, ‘Post‐operative recurrence of Crohn's disease (CD): impact of endoscopic monitoring and treatment step‐up’ . One of its conclusions was that in our postoperative cohort there was no clinical benefit from colonoscopy or step‐up therapy.…”