Therapeutic strategies of Moringa oleifera Lam. (Moringaceae) for stomach and forestomach ulceration induced by HCl/EtOH in rat model

Dalhoumi, Wejden; Guesmi, Fatma; Bouzidi, Amal; Akermi, Sarra; Hfaïedh, Najla; Saidi, Issam

doi:10.1016/j.sjbs.2022.103284

Cited by 8 publications

(8 citation statements)

References 34 publications

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“…The compound pterygospermin found in the roots and flowers of the plant has antifungal activity against Neurospora crassa, Rhizopus stolonifera, Microsporum gypseum, and Aspergillus niger [48]. A range of microbes, including Pseudomonas aeruginosa, Vibrio cholera, and Salmonella typhi, are resistant to the ethanolic extract of the leaves [49].…”

Section: Discussionmentioning

confidence: 99%

Immobilization of silver nanoparticles with gum of Moringa oleifera for effective antibacterial activities against human disease-causing bacterial species

Ali,

Ahmad,

Uddin

et al. 2024

Preprint

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The misuse of antibiotics generates resistant bacterial strains that are extremely dangerous and pose a serious threat to global health systems. This global issue needs a rapid and urgent alternative to control the growth of resistant strains. In this study, a novel strategy was adopted to suppress the growth of resistant pathogens. Here, an immobilization approach was applied using silver nanoparticles (AgNPs) and gum of medicinally important Moringa oleifera. In many studies, the gum and AgNPs alone have proven antibacterial activities. Here, the differential concentrations of AgNPs were immobilized with gum of M. oleifera to investigate its potential against highly resistant pathogens. Immobilization is a powerful technique that is commonly used in pharmaceutics for controlled reactivity and emulsification. The immobilized AgNPs displayed promising activities against highly resistant B. subtilis (23.6mm, 50 µL:200 µL), E. coli (19.3; 75 µL:200 µL), K. pneumoniae (22 mm; 200 µL:200 µL), P. mirabilis (16.3 mm; 100 µL:200 µL), P. aeruginosa (22 mm; 175 µL:200 µL) and S. typhi (19.3; 25 µL: 200 µL) than either AgNPs alone or gum. The immobilized AgNPs released the positive sliver ions and the positively charged nanoparticles (NPs) are attracted by the negatively charged bacterial cells. After attachment and permeation to bacterial cell, the immobilized NPs altering the cell membrane permeability, protein denaturation, causing oxidative stress, deactivating enzymes, generating ROS, DNA damage and changing gene expression level. It has been mechanistically considered that the immobilized AgNPs can kill bacteria by damaging their cell membranes, dephosphorylate tyrosine residues during their signal transduction pathways, cell apoptosis, rupture the organelles and inhibiting the cell division and finally lead to cell death. This study has a potential to be adopted by pharmaceutical industries as highly effective antibacterial alternatives to synthetic drugs.

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Section: Discussionmentioning

confidence: 99%

Immobilization of silver nanoparticles with gum of Moringa oleifera for effective antibacterial activities against human disease-causing bacterial species

Ali,

Ahmad,

Uddin

et al. 2024

Preprint

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“…The CXBCH content is thought to inhibit the meeting of AhR with DMBA (ligand), as there is no activation of the signal transduction pathway of AhR, and no active metabolite of DMBA-DE is formed [ 34 , 54 , 78 ]. Thymoquinone, dithymoquinone, dihydro-thymoquinone, unsaturated fatty acids, and sitosterol are compounds, with a molecular structure similar to AhR ligands [ 55 ], can act as AhR ligands as partial antagonists/agonists and are competitive against DMBA [ 56 ]. Active CXBCH preparations, such as polyphenols, flavonoids, curcumin, and thymoquinone, can competitively block the junction of DMBA with AhR, preventing the formation of the DMBA-AhR complex and preventing AhR receptor activation.…”

Section: Discussionmentioning

confidence: 99%

“…Samples of the extracts and CXBCH preparations that had been incubated were then tested for absorbance values using a UV-vis spectrophotometer at a wavelength of 517 nm. The IC 50 value is the sample concentration required to scavenge 50% of DPPH free radicals, which we calculated by plotting the percent inhibition against the log sample extract concentration [ 55 ].…”

Section: Methodsmentioning

confidence: 99%

Herbal Honey Preparations of Curcuma Xanthorriza and Black Cumin Protect against Carcinogenesis through Antioxidant and Immunomodulatory Activities in Sprague Dawley (SD) Rats Induced with Dimethylbenz(a)anthracene

et al. 2023

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Background: Traditionally, Curcuma xanthorriza (CX), black cumin seed (BC), and honey have been used by the Indonesian people as medicinal ingredients to treat various health symptoms. CX extracts and BC have been proven in the laboratory as chemopreventive agents, antioxidants, and immunomodulators. In this study, we developed CX extract, BC oil, and honey into herbal honey preparations (CXBCH) and hypothesized that the preparations show chemopreventive activity. The purpose of the study was to determine the CXBCH potential as chemopreventive, antioxidant, and immunomodulatory. Method: In this experimental laboratory research, antioxidant, immunomodulatory, and cytotoxic activities were tested on human mammary cancer cell lines (T47D cells) while the chemopreventive activity of the CXBCH preparations on Sprague Dawley (SD) rats induced with dimethylbenzene(a)anthracene (DMBA). Results: CXBCH preparations demonstrated immunomodulatory, antioxidant, and cytotoxic activities in T47D, Hela, and HTB-183 cells and in DMBA-induced SD rats, as the preparations inhibited tumor nodule formation, increased the number of CD4, CD8 and CD4CD25 cells, and glutathione-S-transferase (GST) activity, and decreased serum NO levels. Conclusions: CXBCH preparations display chemopreventive, antioxidant, and immunomodulatory properties.

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Section: Biological Activities Associated With Moringamentioning

confidence: 99%

“…The compound pterygospermin found in the flowers and roots of M. oleifera exhibits powerful antifungal activity against Rhizopus stolonifer, Neurospora crassa, Aspergillus niger, and Microsporum gypseum. 61 The ethanolic extracts of the leaves also show antibiotic activity against a variety of microorganisms, like Pseudomonas aeruginosa, Salmonella typhi, Vibrio cholera, and Escherichia coli. 62 Numerous studies propose that the seed extracts of M. oleifera have a likelihood of being used in water purification because it inhibited the growth of bacteria in both agar and nutrient media.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Moringa oleifera: a valuable insight into recent advances in medicinal uses and pharmacological activities

Jikah,

Edo

2023

J Sci Food Agric

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Moringa oleifera is an important medicinal plant in several countries, e.g. Nigeria, USA, Turkey, Germany, Greece, and Ukraine. The abundant bioactive and nutritional properties of this plant make it useful in many and diverse areas of life including the health, cosmetic, agricultural and food industries to mention but a few. Research has found out that the presence of proteins, carbohydrates, lipids, vitamins, minerals, flavonoids, phenols, alkaloids, fatty acids, saponins, essential oils, folate, aromatic hydrocarbons, sterols, glucosinolates, glycosides among others characterise the Moringa‐ nutrient profile and as a result, give rise to its remedial effects on ailments such like wounds, stomach and duodenal ulcers, allergies, obesity, diabetics, inflammation, asthma, etcetera. It is the aim of this review to provide an insight into such medicinal and pharmacological remedies attributed to Moringa stating both the past and recent discoveries. This review article also takes a look into the botanical features, bioactive compounds, antinutrients, food applications, bacterial fermentation products, biosafety, industrial applications and other uses of Moringa. Finally, with belief that knowledge is progressive, we acknowledge that there are things yet undiscovered about this wonder plant that will be of value both to medicine and general life, we therefore recommend that research work continue on the plant Moringa.This article is protected by copyright. All rights reserved.

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Therapeutic strategies of Moringa oleifera Lam. (Moringaceae) for stomach and forestomach ulceration induced by HCl/EtOH in rat model

Cited by 8 publications

References 34 publications

Immobilization of silver nanoparticles with gum of Moringa oleifera for effective antibacterial activities against human disease-causing bacterial species

Immobilization of silver nanoparticles with gum of Moringa oleifera for effective antibacterial activities against human disease-causing bacterial species

Herbal Honey Preparations of Curcuma Xanthorriza and Black Cumin Protect against Carcinogenesis through Antioxidant and Immunomodulatory Activities in Sprague Dawley (SD) Rats Induced with Dimethylbenz(a)anthracene

Moringa oleifera: a valuable insight into recent advances in medicinal uses and pharmacological activities

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