<p>Cigarette smoke contains 7, 12 dimethylbenzanthracene (DMBA). Metabolic of DMBA is immunosuppressive. Black cumin seed oil (BCSO) is an immunomodulation. The aim of this study was to determine the effect of BCSO on leukocyte, CD4Th and CD4CD25Treg in Sprague-Dawley (SD) mice induced with DMBA. The 96 SD rats were divided into 8 groups of 12. Group I received aquabidest and standard feeding. Groups II, III and IV received BCSO (an equivalent of 6.8, 68 and 136 mg/kg BW / day thymoquinone, respectively). Group V received thymoquinone (50 mg / kg BW / day) and group VI received tamoxifen (60 mg / kg BW). Group VII (DMBA) was induced with DMBA (10x20mg / kg BW for 5 weeks). Group VIII received standard feeding and corn oil treatment. In the third week, all groups began to be induced with DMBA (20 mg/kg BW twice per week for five weeks). Data collection of leukocytes, CD4Th and CD4CD25Treg was performed at week 27th. The mean difference of CD4Th and CD4CD25Treg counts between groups was calculated with one way ANOVA. Results: The administration of BCSO, thymoquinone, and tamoxifen had increased leukocytes and CD4 Th cell count. The CD4Th cell count of the treatment groups was higher than that of the DMBA group (p &lt;0.05). BCSO equivalent doses of 6.8 and 68 mg/kg BW / day thymoquinone showed immunoprotective effects. Conclusion: It can be concluded that the BCSO administration at doses of 6.8 and 68 mg/kg BW / day shows immunoprotective effects due to DMBA induction.</p>

Personal hygiene is one of the basic human needs and must be kept clean, including scalp and hair, eyes, nose, ears, nails of hands and feet, skin and overall body care. Health education on personal hygiene is still concern not only for healthy children but also for children with disabilities. One of the ways is with audiovisual methods. This study aimed to analyze the effect of health education on personal hygiene with audiovisual methods. The study design used was pre-experiment without a control group. The number of samples was 30 using total sampling technique. Knowledge of personal hygiene before health education (pre-test) was mostly insufficient category, after being given health education (post-test) mainly was in proper group. The pre-test attitude was in low category, and the post-test was still the same. Pre-test and post-test of behavior were mostly being practiced. Pre-test and post-test of self-efficacy were in low category. There was an influence of health education on personal hygiene with audiovisual methods on the level of knowledge in intellectually disabled children (p&lt;0.05), but there was no effect on attitudes, behaviors, and self-efficacy in intellectually disabled children.

Objective: The aim of the overall study was to determine the quality of life (QOL) and the factors that influence it in patients with diabetes mellitus (DM) in primary health care (PHC) Jetis 1, Bantul.Methods: This cross-sectional study was conducted on 153 DM patients in PHC Jetis I, Bantul. Respondents were recruited by inclusion and exclusion criteria. Primary data on exposure to cigarette smoke, adherence with physical activity, perception of disease, and QOL are collected through interviews. Data were analyzed by a mean test for ratio scale data and Chi-square test.Results: The results showed that the QOL and the level of adherence of DM patients in Puskesmas Jetis I were classified as very good. Male patients, elementary school graduates, normal body mass index (BMI), normal fasting blood sugar levels, adherent DM medication, and positive disease perception have a greater chance of having a better QOL. The mean of the random blood sugar and the fasting blood sugar levels exceeded the normal values, with 261.70 ± 121.15 mg/dl and 167.43 ± 10.23, respectively.Conclusion: The QOL of DM patients in I Jetis PHC is very good. Men, normal BMI, adherent with medication therapy, and normal fasting sugar levels are associated with an increase in QOL.

Twenty percent of the total number of human leukocytes is lymphocytes. Lymphocytes are responsible for the control of the adaptive immune system. Physical activity is any body movement that requires energy to do it. Physical activity is related to changes in a person's immunity so that it can reduce the risks of diseases such as obesity, hypertension, diabetes, cancer, and stroke. Black Cumin Seed Oil (BCSO) in various studies has been widely used as a supplement, especially as an immune-modulator. The purpose of this study is to see the effect of physical activity on lymphocyte levels in smokers who have been given Black Cumin Seed Oil for 30 days. This study used a single-blind Randomized Controlled Trial (RCT) method, with a total of 36 test subjects divided into four groups. Group 1 received placebo 3x1 capsules/day, group 2 received BCSO 3x1 capsules/day, group 3 received BCSO 3x2 capsules/day, and group 4 received BCSO 3x3 capsules/day. The intervention was carried out for 30 days, then on the 31st-day blood was drawn for analysis. Data analysis using an independent t-test to see the average group with high and low activity, while to see the average lymphocyte between treatment groups using one way ANOVA test. The test results were said to be significant if p &lt;0.05. The p-value of the independent t-test is 0.045, and one way ANOVA test p-value is 0.343. In conclusion, physical activity can increase lymphocyte levels significantly, but not on BCSO administration.

Background: Chronic obstructive pulmonary disease (COPD) has become a huge public health problem in the world. In Asy-Syaafi Hospital, COPD is the most commonly found disease after bcronchitis among the patients in out patient unit of lung desease. Self efficacy showed patients’ confidence in independently managing chronic desease. Wheter they want or not to start the treatment is determined by their self efficacy. Peak expiratory flow rate showed condition and problems of lung function and the narrowing or blockage of the airway. Objective: Identify conditions and problems on self efficacy and Peak expiratory flow rate of COPD patients in Asy-Syaafi Hospital Pamekasan, East Java. Method: This research was descriptive study used non analytic cross sectional design, with total sampling, involving 30 respondents. Data were collected with a questionnaire of the COPD self efficacy (CSES) and peak flow meter. Data analysis was performed with a univariate analysis. Results: Self efficacy was in low category with score less than 99 (86.7%) and peak expiratory flow rate was less than <50% of the PEF (90%). Conclusion: Most of COPD self efficacy in Asy-Syaafi Hospital Pamekasan were in not good category and peak expiratory flow rate contained in red zone or the occurrence of major constriction of the airways. Keywords: COPD, Self Eficacy, Peak Expiratory Flow Rate