Therapeutic strategy for acute appendicitis based on laparoscopic surgery

Shiihara, Masahiro; Sudo, Yasuhiro; Matsushita, Norimasa; Kubota, Takeshi; Hibi, Yasuhiro; Osugi, Harushi; Inoue, Tatsuo

doi:10.1186/s12893-023-02070-y

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…However, due to the specificity of ASA and its complications, LA as the first treatment modality for septic appendicitis is still somewhat controversial. 17 In the present study, we first compared the effects of the two procedures on perioperative indicators of pediatric ASA. Children with LA have shorter operative time, gastrointestinal recovery time, venting time, incision length, and length of hospitalization than patients with OA, and this is consistent with previously reported outcomes.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Laparoscopic Appendectomy and Open Appendectomy on B7-H3-Mediated Intrinsic Immune Response in Children with Acute Suppurative Appendicitis

Duan,

Li,

et al. 2024

JIR

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Surgery impairs immune function and increases postoperative complications. B7H3, a co-stimulatory molecule, plays a crucial role in immune regulation. The present study examined the impact of B7H3 on the postoperative immune response in children with acute suppurative appendicitis (ASA) by comparing preoperative and postoperative B7H3 levels in laparoscopic surgery (LA) and open appendectomy (OA). Patients and Methods: 198 pediatric ASA patients were enrolled. The researcher group performed LA, while the control group performed OA. Perioperative time, recovery time of gastrointestinal function, time to pass gas, length of incision, and length of hospitalization were compared in the perioperative period. Additionally, an ELISA assay was conducted to examine the levels of inflammatory factors and B7H3 and CD28. Short-term postoperative complications were also evaluated. Results: Compared with the control group, the research group had a short operative time, gastrointestinal function recovery time, gas time, and hospitalization time. The short-term complication rate was significantly lower in the research group. More importantly, B7H3 and CD28 were insignificantly different preoperatively, but they were all reduced postoperatively. Moreover, the reduction was more pronounced in the research group. The same results were noted in inflammatory factors and immune markers, which were nonsignificant different preoperatively and were typically reduced postoperatively, particularly in the research group. Finally, postoperative B7H3 was positively correlated with both inflammatory factors and immune cell levels. Conclusion: B7H3 was reduced in both postoperative periods, and the reduction was more pronounced in the LA group. B7H3 may be involved in postoperative recovery by modulating postoperative inflammation and immune responses.

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Section: Discussionmentioning

confidence: 99%

The Impact of Laparoscopic Appendectomy and Open Appendectomy on B7-H3-Mediated Intrinsic Immune Response in Children with Acute Suppurative Appendicitis

Duan,

Li,

et al. 2024

JIR

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Following publication of the original article [1], in this article the text has been inserted to the acknowledgement section and the same will read as follows:The authors thank Editage (www.editage.jp) for English language editing. The authors are grateful to JPSKAK-ENHI #22K16548.

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confidence: 99%

“…Following publication of the original article [1], in this article the text has been inserted to the acknowledgement section and the same will read as follows:…”

mentioning

confidence: 99%

Correction to: Therapeutic strategy for acute appendicitis based on laparoscopic surgery

Shiihara,

Sudo,

Matsushita

et al. 2023

BMC Surg

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MaskAppendix: Backbone-Enriched Mask R-CNN Based on Grad-CAM for Automatic Appendix Segmentation

Dandıl,

Baştuğ,

Yıldırım

et al. 2024

Diagnostics

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Background: A leading cause of emergency abdominal surgery, appendicitis is a common condition affecting millions of people worldwide. Automatic and accurate segmentation of the appendix from medical imaging is a challenging task, due to its small size, variability in shape, and proximity to other anatomical structures. Methods: In this study, we propose a backbone-enriched Mask R-CNN architecture (MaskAppendix) on the Detectron platform, enhanced with Gradient-weighted Class Activation Mapping (Grad-CAM), for precise appendix segmentation on computed tomography (CT) scans. In the proposed MaskAppendix deep learning model, ResNet101 network is used as the backbone. By integrating Grad-CAM into the MaskAppendix network, our model improves feature localization, allowing it to better capture subtle variations in appendix morphology. Results: We conduct extensive experiments on a dataset of abdominal CT scans, demonstrating that our method achieves state-of-the-art performance in appendix segmentation, outperforming traditional segmentation techniques in terms of both accuracy and robustness. In the automatic segmentation of the appendix region in CT slices, a DSC score of 87.17% was achieved with the proposed approach, and the results obtained have the potential to improve clinical diagnostic accuracy. Conclusions: This framework provides an effective tool for aiding clinicians in the diagnosis of appendicitis and other related conditions, reducing the potential for diagnostic errors and enhancing clinical workflow efficiency.

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Therapeutic strategy for acute appendicitis based on laparoscopic surgery

Cited by 3 publications

References 27 publications

The Impact of Laparoscopic Appendectomy and Open Appendectomy on B7-H3-Mediated Intrinsic Immune Response in Children with Acute Suppurative Appendicitis

The Impact of Laparoscopic Appendectomy and Open Appendectomy on B7-H3-Mediated Intrinsic Immune Response in Children with Acute Suppurative Appendicitis

Correction to: Therapeutic strategy for acute appendicitis based on laparoscopic surgery

MaskAppendix: Backbone-Enriched Mask R-CNN Based on Grad-CAM for Automatic Appendix Segmentation

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