Therapeutic use of hormones on tendinopathies: a narrative review

Abate, Michele; Guelfi, Matteo; Pantalone, Andrea; Vanni, Daniele; Schiavone, Cosima; Andı́a, Isabel; Salini, Vincenzo

doi:10.11138/mltj/2016.6.4.445

Cited by 7 publications

(6 citation statements)

References 47 publications

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“…Specialized testosterone receptors have been reported to be present in tendons. In vitro studies have shown that high concentrations of dihydrotestosterone increase the production of tenocytes in tendons; therefore, testosterone appears to lead to the differentiation of mesenchymal pluripotent cells in tendons (18). According to the above information, it appears that in present study palm pollen could increase the Scx gene expression levels in tendon tissue of male adult rats via increasing testosterone.…”

Section: Discussionsupporting

confidence: 47%

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The Effects of Resistance Training with Palm Pollen on Scleraxis Protein and Gene Expression Levels in the Tendon Tissue of Male Adult Rats

et al. 2019

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Background and objectives: Controlling nutrition and exercise can be two important strategies in controlling tendon health. It has been reported that resistance training and palm pollen separately can improve Scleraxis (Scx) in tendon tissue; so present study aimed to investigate the interactive effects of resistance training with ethanolic extract of palm pollen on Scx protein and gene expression levels in the tendon tissue of male adult rats. Methods: In this experimental study 30 male adult rats divided into 6 groups of 6 rats including: 1) sham, 2) training, 3) palm pollen, 4) testosterone, 5) training + palm pollen, and 6) training + testosterone. During 4 weeks, groups 2, 5, and 6 performed resistance trainings for five sessions per week; groups 3 and 5 received 100 mg/kg palm pollen for five days per week via gavage and groups 4 and 6 received 2 mg/kg testosterone propionate peritoneally. Scx protein and gene expression levels were measured in tendon tissue by Western blot and real-time PCR methods respectively. Shapiro-Wilk, one way ANOVA with Tukey's post-hoc tests were used to analyze the findings (P≤0.05). Results: Training significantly increased Scx protein levels (P=0.005); palm pollen significantly increased Scx gene expression levels (P=0.001); training + palm pollen significantly increased Scx protein and gene expression levels (P=0.001) also training + palm pollen had more favorable effect on increase of Scx protein and gene expression levels compared to training and palm pollen alone (P=0.001). Conclusion: It seems that resistance training simultaneously with palm pollen administration can have a more favorable effect than each one alone on improving Scx protein and gene expression levels in tendon tissue of male adult rats.

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Section: Discussionsupporting

confidence: 47%

“…Therefore, consumption of palm pollen can increase testosterone levels (9). Testosterone consumption has been shown to improve levels of tenocytes as well as types 1 and 2 collagen (10). Therefore, consumption of palm pollen seems to have similar effects to testosterone in strengthening and improving tendon tissue.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Resistance Training with Palm Pollen on Scleraxis Protein and Gene Expression Levels in the Tendon Tissue of Male Adult Rats

et al. 2019

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“…Hormonal fluctuations that are typical for the menstrual cycle have not been associated with modifications of tendon function [ 90 , 91 ]. A review summarizes that high or low levels of sexual hormones (estrogen, progesterone and testosterone) are not directly causing tendinopathies but may play a role in tendon pathologies [ 92 ]. Therefore, individual hormonal status should be taken into account for injury risk of female and male runners as well as for their therapies and prevention [ 92 ].…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Differences in Running Injuries: A Systematic Review with Meta-Analysis and Meta-Regression

et al. 2021

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Background Running is a popular sport with high injury rates. Although risk factors have intensively been investigated, synthesized knowledge about the differences in injury rates of female and male runners is scarce. Objective To systematically investigate the differences in injury rates and characteristics between female and male runners. Methods Database searches (PubMed, Web of Science, PEDro, SPORTDiscus) were conducted according to PRISMA guidelines using the keywords “running AND injur*”. Prospective studies reporting running related injury rates for both sexes were included. A random-effects meta-analysis was used to pool the risk ratios (RR) for the occurrence of injuries in female vs. male runners. Potential moderators (effect modifiers) were analysed using meta-regression. Results After removal of duplicates, 12,215 articles were screened. Thirty-eight studies were included and the OR of 31 could be pooled in the quantitative analysis. The overall injury rate was 20.8 (95% CI 19.9–21.7) injuries per 100 female runners and 20.4 (95% CI 19.7–21.1) injuries per 100 male runners. Meta-analysis revealed no differences between sexes for overall injuries reported per 100 runners (RR 0.99, 95% CI 0.90–1.10, n = 24) and per hours or athlete exposure (RR 0.94, 95% CI 0.69–1.27, n = 6). Female sex was associated with a more frequent occurrence of bone stress injury (RR (for males) 0.52, 95% CI 0.36–0.76, n = 5) while male runners had higher risk for Achilles tendinopathies (RR 1. 86, 95% CI 1.25–2.79, n = 2). Meta-regression showed an association between a higher injury risk and competition distances of 10 km and shorter in female runners (RR 1.08, 95% CI 1.00–1.69). Conclusion Differences between female and male runners in specific injury diagnoses should be considered in the development of individualised and sex-specific prevention and rehabilitation strategies to manage running-related injuries.

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“…This paradigm may be of particular importance since increased levels of circulating IGF1 do not entail their biological action locally at the tendon, but rather only local IGF1 can stimulate and regulate collagen synthesis in tendon tissue. 63 Similarly, IGFBPs bind chondrocytesecreted IGF1 and induce the production of cartilage ECM ultimately exerting a protective role in OA. 64 Moreover, IGFPBs are normally localized within the fibronectin network in cartilage ECM thus creating reservoirs of IGF1 with important roles in cartilage homeostasis and repair.…”

Section: Functional Analysis Of the Effect Of The Hamsc Secretome On Inflamed Chondrocytes And Tenocytesmentioning

confidence: 99%

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues

Ragni

Papait

Orfei

et al. 2021

Stem Cells Translational Medicine

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Human amniotic membrane-derived mesenchymal stromal cells (hAMSCs) are easily obtained in large quantities and free from ethical concerns. Promising therapeutic results for both hAMSCs and their secreted factors (secretome) were described by several in vitro and preclinical studies, often for treatment of orthopedic disorders such as osteoarthritis (OA) and tendinopathy. For clinical translation of the hAMSC secretome as cell-free therapy, a detailed characterization of hAMSC-secreted factors is mandatory. Herein, we tested the presence of 200 secreted factors and 754 miRNAs in extracellular vesicles (EVs). Thirty-seven cytokines/chemokines were identified at varying abundance, some of which involved in both chemotaxis and homeostasis of inflammatory cells and in positive remodeling of extracellular matrix, often damaged in tendinopathy and OA. We also found 336 EV-miRNAs, 51 of which accounted for more than 95% of the genetic message. A focused analysis based on miRNAs related to OA and tendinopathy showed that most abundant EV-miRNAs are teno-and chondro-protective, able to induce M2 macrophage polarization, inhibit inflammatory T cells, and promote Treg. Functional analysis on IL-1β treated tenocytes and chondrocytes resulted in downregulation of inflammation-associated genes. Overall, presence of key regulatory molecules and miRNAs explain the promising therapeutic results of hAMSCs and their secretome for treatment of musculoskeletal conditions and are a groundwork for similar studies in other pathologies. Furthermore, identified molecules will pave the way for future studies aimed at more Enrico Ragni and Andrea Papait contributed equally to the work.

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Therapeutic use of hormones on tendinopathies: a narrative review

Cited by 7 publications

References 47 publications

The Effects of Resistance Training with Palm Pollen on Scleraxis Protein and Gene Expression Levels in the Tendon Tissue of Male Adult Rats

The Effects of Resistance Training with Palm Pollen on Scleraxis Protein and Gene Expression Levels in the Tendon Tissue of Male Adult Rats

Sex-Specific Differences in Running Injuries: A Systematic Review with Meta-Analysis and Meta-Regression

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues

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