Therapeutic value of 3-D printing template-assisted &lt;sup&gt;125&lt;/sup&gt;I-seed&amp;nbsp;implantation in the treatment of malignant liver tumors

Han, Tao; Yang, Xiaodan; Xu, Ying; Zheng, Zhendong; Yan, Ying; Wang, Ning

doi:10.2147/ott.s134290

Cited by 16 publications

(12 citation statements)

References 9 publications

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“…According to preoperative CT data, a high-precision 3D model can be printed and used to make the morphology of an implantation material conform to individual anatomy[20,23-26]. This technology has also been preliminarily applied in template preparations for neck, pulmonary, abdominal, and pelvic tumor iodine-125 seed implantation, and the postoperative dosimetry was consistent with treatment planning[12,27,28].…”

Section: Discussionmentioning

confidence: 99%

Preliminary application of 3D-printed coplanar template for iodine-125 seed implantation therapy in patients with advanced pancreatic cancer

Huang

Chen

et al. 2018

WJG

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AIMTo evaluate a 3D-printed coplanar template for iodine-125 seed implantation therapy in patients with pancreatic cancer.METHODSA retrospective analysis of our database was performed, and a total of 25 patients with pancreatic cancer who underwent iodine-125 seed implantation between January 2014 and November 2017 were analyzed. Of these, 12 implantations were assisted by a 3D-printed coplanar template (group A), and 13 implantations performed freehand were selected as a control group (group B). A 3D coplanar template was designed and printed according to a preoperative CT scan and treatment planning system. The iodine-125 seeds were then implanted using the template as a guide. Dosimetric verification was performed after implantation. Pre- and postoperative D90, V100, and V150 were calculated. The success rate of iodine-125 seed implantation, dosimetric parameters, and complications were analyzed and compared between the two groups.RESULTSIodine-125 seed implantation was successfully performed in both groups. In group A, the median pre- and postoperative D90 values were 155.32 ± 8.05 Gy and 154.82 ± 16.43 Gy, respectively; the difference between these values was minimal and not statistically significant (P > 0.05). Postoperative V100 and V150 were 91.05% ± 4.06% and 64.54% ± 13.40%, respectively, which met the treatment requirement. A better dosimetric parameter was observed in group A than in group B, and the difference was statistically significant (V100: 91.05% ± 4.06% vs 72.91% ± 13.78%, P < 0.05). No major procedure-related complications were observed in either group. For group A, mild hemorrhage was observed in 1 patient with a peritoneal local hematoma due to mesenteric vein damage from the iodine-125 seed implantation needle. The hematoma resolved spontaneously without treatment. Postoperative blood amylase levels remained within the normal range for all patients.CONCLUSIONA 3D-printed coplanar template appears to be a safe and effective iodine-125 seed implantation guidance tool to improve implantation accuracy and optimize dosimetric distribution.

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Section: Discussionmentioning

confidence: 99%

Preliminary application of 3D-printed coplanar template for iodine-125 seed implantation therapy in patients with advanced pancreatic cancer

Huang

Chen

et al. 2018

WJG

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“…In total, 145 candidate publications were retrieved. Ultimately, 16 studies [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] which fullfilled the eligibility criteria were included in the final analysis (see Fig. 1 for further details).…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…All of the researches originated from China., including 16 non-RCTs. Eight original articles [12][13][14][15][16][17][18][19] with 280 patients compared the dose distribution differences between 3D print template-assisted implantation and traditional free-hand implantation. Among them, 128 patients received 3D print template-assisted RIS implantation and 152 without template.…”

Section: Literature Search Resultsmentioning

confidence: 99%

Dosimetry study of three-dimensional print template for 125I implantation therapy

Chen

Zhang

et al. 2021

Radiat Oncol

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Background 125I seed implantation has been found to show good therapeutic effects on tumors. Recent studies showed that three-dimensional (3D) print template-assisted 125I seed implantation can optimize radiation dose distribution. This study aimed to compare the dose distribution differences in 125I seed implantation among 3D print noncoplanar template- (3DPNCT), 3D print coplanar template- (3DPCT) assisted implantation and traditional free-hand implantation. Methods We systematically searched the PubMed, EMbase, Cochrane Library, Wan Fang Med Online, China National Knowledge Infrastructure (CNKI) from the earliest to November 2020 without time or language restrictions. And the references of primary literature were also searched. The outcome measures were dosimetry and operation time. This meta-analysis was carried out using Stata 12.0. Results A total of 16 original articles were selected for inclusion. The differences of D90, D100, V90, and V100 values pre- and post-implantation with traditional free-hand implantation showed statistically significant (p < 0.05). The differences of D90, D100, V100, V150, V200, and D2cc of organs at risk (OAR) values pre- and post-implantation with 3D print template showed no statistically significant (p > 0.05). Compared with traditional free-hand implantation without any templates, 3D print template could improve postoperative D90 (Standard mean difference, SMD = 0.67, 95% confidence interval (CI) = 0.35 to 0.98, p < 0.001), D100 (SMD = 0.82, 95%CI = 0.40 to 1.23, p < 0.001), V90 (SMD = 1.48, 95%CI = 0.95 to 2.00, p < 0.001), V100 (SMD = 1.41, 95%CI = 0.96 to 1.86, p < 0.001), and reduce operation time (SMD = − 0.93, 95%CI = − 1.34 to − 0.51, p < 0.001). In three studies, both 3DPNCT and 3DPCT plans were designed for all patients. The prescribed dose and seed activity were same. Pooled analysis of D90, D100, V100, D2cc of OAR, number of seeds and number of needles showed no significant differences between 3DPNCT and 3DPCT groups (p > 0.05). However, in 3DPNCT group, V150 and V200 were increased (SMD = 0.35, 0.49; 95%CI = 0.04 to 0.67, 0.02 to 0.96; p = 0.028, 0.043); the number of through bone needles was reduced (SMD = − 1.03, 95%CI = − 1.43 to − 0.64, p < 0.001). Conclusions Compared with traditional free-hand implantation, 3D print template-assisted 125I seeds implantation can optimize dose distribution and reduce the implantation time at the same time. Compared with 3D print coplanar template, 3D print noncoplanar template can increase the volume of high dose within tumor target and is more safer in the respect of puncture route.

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“…Han et al . [ 18 ] compared the differences of dosimetric parameters between RIS implantation assisted with 3D-PNCT and without 3D-PNCT in treating liver tumors. The results showed that D 100 , V 100 , and V 150 values were significantly different between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Dosimetric comparison of computed tomography-guided iodine-125 seed implantation assisted with and without three-dimensional printing non-coplanar template in locally recurrent rectal cancer: a propensity score matching study

Wang¹,

Wang²,

Jiang³

et al. 2021

jcb

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Purpose To compare post-implant dosimetric parameters of computed tomography (CT)-guided radioactive iodine-125 ( 125 I) seed (RIS) implantation assisted with and without three-dimensional printing non-coplanar template (3D-PNCT) in locally recurrent rectal cancer (LRRC). Material and methods One hundred and fifty-five LRRC patients treated by CT-guided RIS implantation assisted with or without 3D-PNCT from October 2003 to May 2019 were included in this study. Propensity score matching (PSM) method (1 : 1) was used to adjust for differences between the 3D-group (with 3D-PNCT) and the CT-group (without 3D-PNCT). After PSM, dosimetric parameters [D 90 (dose that covered 90% of target volume), D 100 (dose that covered 100% of target volume), V 100 (percentage of gross tumor volume (GTV) receiving 100% of prescription dose), V 150 (percentage of GTV receiving 150% of prescription dose), HI (homogeneity index), CI (conformity index), and EI (external index)] of the two groups were compared. Results After PSM, 45 pairs of matched cases were selected for analysis and differences in variables between the two groups were balanced. For the 3D-group, median values of D 90 , D 100 , V 100 , V 150 , EI, and HI were 142.6 Gy (73.7-218.2 Gy), 73.7 Gy (26.2-169.3 Gy), 94.1% (74.3-100%), 71.8% (35.4-98.3%), 0.7 (0.1-30.7), and 0.20 (0-0.60), respectively, and corresponding values were 119.9 Gy (39.8-159.3 Gy), 47.0 Gy (13.0-200.9 Gy), 89.9% (38.6-100%), 62.8% (14.8-100%), 0.39 (0-11.01), and 0.30 (0-0.95), respectively, for the CT-group. Parameters including D 90 , D 100 , V 100 , V 150 , and EI in the 3D-group were significantly higher than those in the CT-group ( p < 0.001, p < 0.001, p < 0.001, p < 0.001, and p = 0.006, respectively). Conclusions 3D-PNCT can improve the accuracy of radioactive seed implantation by increasing the dose delivered to the tumor and reducing the number of “cold” spots of dose.

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Therapeutic value of 3-D printing template-assisted <sup>125</sup>I-seed implantation in the treatment of malignant liver tumors

Cited by 16 publications

References 9 publications

Preliminary application of 3D-printed coplanar template for iodine-125 seed implantation therapy in patients with advanced pancreatic cancer

Preliminary application of 3D-printed coplanar template for iodine-125 seed implantation therapy in patients with advanced pancreatic cancer

Dosimetry study of three-dimensional print template for 125I implantation therapy

Dosimetric comparison of computed tomography-guided iodine-125 seed implantation assisted with and without three-dimensional printing non-coplanar template in locally recurrent rectal cancer: a propensity score matching study

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