Therapeutics of nature—The invisible sutures of “spontaneous closure”

Prevalence of congenital heart defects in neuroblastoma patients: a cohort study and systematic review of literature

“…Another explanation for the difference in outcome of our study and the study by George et al might be that patients in our study were older at time of echocardiography. Because some types of CHD can resolve spontaneously over time, such as spontaneous closure of septal defects [ 27 ], CHD might have been missed in our study. One patient in our study indeed had a VSD that had spontaneously closed.…”

A preliminary report: Severe respitatory distress in transitional newborn lambs with recovery following nonnutrivite sucking

“…He concluded by requesting the development of a preventive measure, safe to give all transitional newborns during the first minutes of life. Almost simultaneously, Perloff called our attention to therapeutics of nature, and asked that such naturally occurring therapeutic phenomena be given the opportunity to occur. Next, Burch discussed isolated and artificial therapeutic ventures which poorly replicate the effects of the mixtures found in nature.…”

Spontaneous closure of congenital ventricular septal defect in an adult

“…Spontaneous closure of ventricular septal defect in infancy and childhood has been well described (Editorial, 1967;Perloff, 1971), but documented cases of spontaneous closure in the adult have been rare (Corone er al., 1977;Schott, 1973;Suzuki, 1969;Wise and Wilson, 1979) (Table I). In a review of 790 cases of ventricular septal defect, none closed spontaneously after age 20 (Corone el al., 1977).…”

“…Spontaneous closure of ventricular septal defect in infancy and childhood is a well-known medical fact (Editorial, 1967;Perloff, 1971). Only a few cases have been reported in adults in the clinical and pathologic literature (Schott, 1973;Wise and Wilson, 1979).…”