Therapie der benignen Prostatahyperplasie mit Bazoton Liquidum

Engelmann, U.; Boos, Gustavo Luchi; Kres, Heinz

doi:10.1007/s001310050032

Cited by 27 publications

(13 citation statements)

References 6 publications

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“…17 Since these first observations, various extracts of Urtica dioica were commonly used in the treatment of prostate diseases. 18 Some extracts from Urtica dioica roots were demonstrated to exert proliferation-reducing effects in an in vivo animal model. 9,19 The effects of Urtica dioica extracts in prostate diseases are still controversially discussed as no clear mechanism(s) has yet been established.…”

Section: Discussionmentioning

confidence: 99%

Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

Durak

Biri²,

Devrım³

et al. 2004

Cancer Biology & Therapy

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Aim: Investigation of possible effects of aqueous extract of Urtica dioica leaves on adenosine deaminase activity in prostate tissue from patients with prostate cancer.Methods: Ten prostate tissues from patients with pathologically proven localized prostate cancer (Gleason scores 4 to 7) were used in the study. In the tissues, ADA activities with and without preincubation with different amounts of Urtica dioica extracts were performed.Results: Aqueous extract of Urtica dioica results in significant inhibition on adenosine deaminase (ADA) activity of prostate tissue.Conclusion: ADA inhibition by Urtica dioica extract might be one of the mechanisms in the observed beneficial effect of Urtica dioica in prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

Durak

Biri²,

Devrım³

et al. 2004

Cancer Biology & Therapy

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“…Die Datenlage zu Brennnesselwurzelextraktpräparaten ist bislang begrenzt und beruht auf Daten älter Studien mit geringer Patientenzahl und kurzer Studiendauer [6,9,17]. Bislang konnte in einer Studie an 41 Patienten über 12 Wochen mit einem Flüssigpräparat eine signifikante Verbesserung des IPSS um 4,7 Punkte gegenüber Placebo nachgewiesen werden.…”

Section: Extract Of Stinging Nettle Roots (Bazoton ® -Uno) In Long-teunclassified

Brennnesseltrockenextrakt (Bazoton � -uno) in der Langzeittherapie des benignen Prostatasyndroms (BPS)

Schneider

Rübben

2004

Der Urologe A

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Phytotherapy of BPS has a long tradition in Germany; nevertheless, data referring to single phytotherapeutic agents are rare. We therefore performed a randomized, double-blind, placebo-controlled multicenter study for 1 year with Bazoton uno (459 mg dry extract of stinging nettle roots) with 246 patients. The IPSS decreased on average from 18.7+/-0.3 to 13.0+/-0.5 with a statistically significant difference compared to placebo (18.5+/-0.3 to 13.8+/-0.5; p=0.0233). The median Q(max) increased by 3.0+/-0.4 ml/s in comparison to 2.9+/-0.4 ml/s (placebo), thus not statistically significantly different, as well as the median volume of residual urine, which changed from 35.5+/-3.4 ml before therapy to 20.0+/-2.8 ml and from 40.0+/-4.0 ml to 21.0+/-2.9 ml under placebo application. The number of adverse events (29/38) as well as urinary infections etc. (3/10 events) was smaller under Bazoton uno therapy compared to placebo. Treatment with Bazoton uno can therefore be considered a safe therapeutic option for BPS, especially for reducing irritative symptoms and BPS-associated complications due to the postulated antiphlogistic and antiproliferative effects of the stinging nettle extract. A strong increase of Q(max) or reduction of residual urine are not to be expected.

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“…There are at least 16 different preparations available that utilize various extraction processes using methanol, ethanol, or exhaustive percolation with hot water. Only one recent placebo-controlled study was undertaken [26]. A liquid preparation of stinging nettle was shown to be superior to placebo in terms of IPSS improvement.…”

Section: Urtica Dioica (Stinging Nettle)mentioning

confidence: 98%

Review of recent placebo-controlled trials utilizing phytotherapeutic agents for treatment of BPH

Lowe

Dreikorn²,

Borkowski³

et al. 1998

Prostate

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Therapie der benignen Prostatahyperplasie mit Bazoton Liquidum

Cited by 27 publications

References 6 publications

Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

Brennnesseltrockenextrakt (Bazoton � -uno) in der Langzeittherapie des benignen Prostatasyndroms (BPS)

Review of recent placebo-controlled trials utilizing phytotherapeutic agents for treatment of BPH

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