Therapie der Migräneattacke und Prophylaxe der Migräne

Diener, H.-C.; Gaul, Charly; Kropp, Peter

doi:10.1055/s-0038-1673598

Cited by 11 publications

(2 citation statements)

References 450 publications

(263 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…35 Migraine treatment consists of acute therapy, eg, nonsteroidal anti-inflammatory drugs (NSAIDs) or triptans, 53 lifestyle changes, and pharmacologic prophylaxis if attacks are frequent or insufficiently controlled by acute medication. 17 Evidence from experimental and clinical studies has shown that placebo treatments or experimentally modulated expectations can significantly improve acute and chronic pain states 5,7,12 and reduce the severity of migraine attacks 16,58 (for review, see Speciali et al 49 ). Furthermore, it is increasingly recognized that these placebo effects are not limited to placebo treatments but can also modulate the efficacy of active pharmacological treatments.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The beneficial effect of positive treatment expectations on pharmacological migraine prophylaxis

Schmidt¹,

Berding²,

Kleine-Borgmann³

et al. 2021

Pain

View full text Add to dashboard Cite

Migraine is one of the leading causes of years lived with disability and considered to be a major global health concern. Pharmacological preventive treatment often causes side effects that limit the adherence to longer-term treatment regimens. Both experimental and clinical evidence suggests that positive expectations can modulate pain and analgesic treatment effects. However, the role of expectations in migraine prophylactic treatment has not systematically been investigated. Here, we examined the influence of treatment expectation before commencing pharmacological preventive treatment on its efficacy and tolerability in N 5 134 episodic (30%) and chronic migraine (70%) patients in a prospective, longitudinal observational study over the course of 6 months. The migraine prophylaxis reduced the number of headache and migraine days with acceptable tolerability. Positive treatment expectation was associated with a generally lower number of headache and migraine days and a stronger reduction in headache days over the course of the treatment in chronic but not in episodic migraine patients. Moreover, patients with prior treatment showed a stronger reduction in headache days with higher expectation as compared to patients without prior experience. Our results underscore the relevance of further exploring the role of treatment expectation and its systematic modulation in patients with migraine and other pain conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The beneficial effect of positive treatment expectations on pharmacological migraine prophylaxis

Schmidt¹,

Berding²,

Kleine-Borgmann³

et al. 2021

Pain

View full text Add to dashboard Cite

show abstract

Migräne im Kindes- und Jugendalter – Ausblick auf innovative Behandlungsansätze im Rahmen multimodaler Therapiekonzepte

Bonfert

Börner

Gerstl

et al. 2020

Bundesgesundheitsbl

View full text Add to dashboard Cite

ZusammenfassungDie Migräne ist auch im Kindes- und Jugendalter ein häufiges, aber in klinischer Versorgung und Wissenschaft oft unterrepräsentiertes Krankheitsbild. Gerade im Kindes- und Jugendalter bestehen relevante Einschränkungen der Lebensqualität durch das (häufige) Schmerzerfahren. Bedingt durch die entwicklungsspezifisch hohe Vulnerabilität des adoleszenten Gehirns besteht ein hohes Chronifizierungs- und Persistenzrisiko bis ins Erwachsenenalter hinein. In diesem Beitrag werden die Bestandteile eines patientenzentrierten, multimodalen Therapiekonzepts dargestellt. Darüber hinaus werden die aktuellsten Erkenntnisse zu den pathophysiologischen Grundlagen der Migräneerkrankung beleuchtet, nach denen Migräne durch einen sich phasenweise verändernden Funktionszustand des Gehirns entsteht (Stichwort: „migraine is a brain state“). Auch periphere Komponenten wie Muskelschmerzen, -verspannungen und -triggerpunkte spielen eine wichtige Rolle. Vor diesem Hintergrund werden nichtpharmakologische innovative Therapieansätze vorgestellt, die auf dem Prinzip der Neuromodulation beruhen, mit Fokus auf der repetitiven peripheren Magnetstimulation.

show abstract