Therapie des Herpes zoster und der postherpetischen Neuralgie

Hüning, Svea; Dücker, Laura von; Kohl-Heckl, Wiebke Kathrin; Nashan, D.

doi:10.1007/s00105-019-4446-0

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…VZV, an a-herpesvirus, usually causes infections during childhood (chickenpox) and then becomes persistent and latent. Virus reactivation leads to shingles, also known as herpes zoster (HZ), and possible further serious complications (83)(84)(85)(86)(87)(88). Another example is the human cytomegalovirus (CMV), which is highly prevalent in adults worldwide.…”

Section: Introductionmentioning

confidence: 99%

Aging and Options to Halt Declining Immunity to Virus Infections

et al. 2021

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Immunosenescence is a process associated with aging that leads to dysregulation of cells of innate and adaptive immunity, which may become dysfunctional. Consequently, older adults show increased severity of viral and bacterial infections and impaired responses to vaccinations. A better understanding of the process of immunosenescence will aid the development of novel strategies to boost the immune system in older adults. In this review, we focus on major alterations of the immune system triggered by aging, and address the effect of chronic viral infections, effectiveness of vaccination of older adults and strategies to improve immune function in this vulnerable age group.

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Section: Introductionmentioning

confidence: 99%

Aging and Options to Halt Declining Immunity to Virus Infections

et al. 2021

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“…PHN is defined as skin-distributed pain that persists for at least 3 months after acute HZ (Salvetti et al, 2019 ). The treatment for PHN focuses on symptom control, including the use of topical lidocaine or capsaicin and oral gabapentin, pregabalin, or tricyclic antidepressants (Hempstead et al, 2020 ; Kopel and Brower, 2020 ), as well as the improvement of immunity and antiviral treatments (Huning et al, 2019 ; Hunter et al, 2020 ). The analgesic effects of traditional treatments have not been reported to have good efficacy among PHN patients with older age, serious skin lesions, or long disease courses.…”

Section: Chronic Pain In Hypo-immunity Individualsmentioning

confidence: 99%

Management of Immunity Alteration-Induced Chronic Pain During the Coronavirus Disease-2019 (COVID-19) Pandemic

et al. 2020

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Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was identified at the end of 2019, has become a widespread, global public health crisis, raising many concerns (Khan et al., 2020). According to the newest data from the World Health Organization (WHO), global SARS-CoV-2 infection cases have reached 18.6 million, with the reported deaths of more than 700,000 individuals (WHO, 2020). Coronaviruses are enveloped, positive-stranded RNA viruses, with an average diameter of 100 nm. The genome length of most coronaviruses ranges from 26 to 32 kb. Coronaviruses can infect various vertebrate species, including bats, dogs, and humans (Fan et al., 2019; Sit et al., 2020). Since the start of the Twenty one century, humans have encountered coronavirus outbreaks three times: severe acute respiratory syndrome-associated coronavirus (SARS-CoV-1), in 2003 (de Wit et al., 2016), Middle East respiratory syndrome-related coronavirus (MERS-CoV), in 2008 (Hemida et al., 2020), and SARS-CoV-2, in 2019 (Wu F. et al., 2020). Genetic comparisons have indicated 79.5% similarity between SARS-CoV-2 and SARS-CoV, and the similarity is up to 96% between SARS-CoV-2 and a coronavirus strain isolated from bats (Zhou et al., 2020). According to the structural and genome-wide association studies, SARS-CoV-2 can more easily infect and replicate in host cells than other coronaviruses (Gussow et al., 2020; Yan et al., 2020). SARS-CoV-2 infections are responsible for the ongoing, global COVID-19 pandemic, which has a fatality rate between 2 and 4% (Weiss and Murdoch, 2020). SARS-CoV-2 infections result in major impacts on the human respiratory system (

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“…It has been reported that age, immune deficiencies, malignancies, organ transplantations, autoimmune diseases, emotional stress, and immunosuppressive therapies are the major risks for HN 9,10 . Clinical treatment for HN only focuses on symptom control, including the use of topical lidocaine or capsaicin and oral gabapentin, pregabalin, or tricyclic antidepressants, 11,12 as well as the improvement of immunity and antiviral treatments 13,14 …”

Section: Introductionmentioning

confidence: 99%

“…9,10 Clinical treatment for HN only focuses on symptom control, including the use of topical lidocaine or capsaicin and oral gabapentin, pregabalin, or tricyclic antidepressants, 11,12 as well as the improvement of immunity and antiviral treatments. 13,14 VZV is a human α herpes virus with strong species specificity that has no animal storage host, and human is the only natural host. VZV reactivates when the individual's immunity is decreased and subsequently resulted in HN.…”

Section: Introductionmentioning

confidence: 99%

HSV‐1 infection‐induced herpetic neuralgia involves a CCL5/CCR5‐mediated inflammation mechanism

Yang

et al. 2023

Journal of Medical Virology

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Herpetic-related neuralgia (HN) caused by varicella-zoster virus (VZV) infection is one of the most typical and common neuropathic pain in the clinic. However, the potential mechanisms and therapeutic approaches for the prevention and treatment of HN are still unclear. This study aims to provide a comprehensive understanding of the molecular mechanisms and potential therapeutic targets of HN. We used an HSV-1 infection-induced HN mouse model and screened the differentially expressed genes (DEGs) in the DRG and spinal cord using an RNAseq technique. Moreover, bioinformatics methods were used to figure out the signaling pathways and expression regulation patterns of the DEGs enriched.In addition, quantitative real-time RT-PCR and western blot were carried out to further confirm the expression of DEGs. HSV-1 inoculation in mice resulted in mechanical allodynia, thermal hyperalgesia, and cold allodynia, following the infection of HSV-1 in both DRG and spinal cord. Besides, HSV-1 inoculation induced an up-regulation of ATF3, CGRP, and GAL in DRG and activation of astrocytes and microglia in the spinal cord. Moreover, 639 genes were upregulated, 249 genes were downregulated in DRG, whereas 534 genes were upregulated and 12 genes were downregulated in the spinal cord of mice 7 days after HSV-1 inoculation. GO and KEGG enrichment analysis suggested that immune responses and cytokine-cytokine receptor interaction are involved in DRG and spinal cord neurons in mice after HSV-1 infection. In addition, CCL5 and its receptor CCR5 were significantly upregulated in DRG and spinal cord upon HSV-1 infection in mice. And blockade of CCR5 exhibited a significant analgesic effect and suppressed the upregulation of inflammatory cytokines in DRG and spinal cord induced by HSV-1 infection in mice. HSV-1 infection-induced allodynia and hyperalgesia in mice through dysregulation of immune response and cytokine-cytokine receptor interaction mechanism. Blockade of CCR5 alleviated allodynia and hyperalgesia probably through the suppression of

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Therapie des Herpes zoster und der postherpetischen Neuralgie

Cited by 7 publications

References 25 publications

Aging and Options to Halt Declining Immunity to Virus Infections

Aging and Options to Halt Declining Immunity to Virus Infections

Management of Immunity Alteration-Induced Chronic Pain During the Coronavirus Disease-2019 (COVID-19) Pandemic

HSV‐1 infection‐induced herpetic neuralgia involves a CCL5/CCR5‐mediated inflammation mechanism

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