Therapy for Heart Failure: The Leipzig Approach

Gummert, Jan; Barten, M.; Rahmel, Axel; Doll, Sophia; Krakor, Ralf; Garbade, Jens; Autschbach, Rüdiger

doi:10.1055/s-0037-1601348

Cited by 4 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Heart failure (HF) is one of the leading causes of death in the developed world. 1 In stage D of HF, after exhaustion of medical therapy, either cardiac transplantation or mechanical circulatory support (MCS) is recommended. 2 Moreover, the importance of assist devices as destination treatment measure by left ventricular failure grows continuously due to a shortage of donor's hearts and the accepted use as destination therapy (DT).…”

Section: Introductionmentioning

confidence: 99%

Impact of preoperative extracorporeal life support on left ventricular assist device outcomes: A comparative study

et al. 2019

View full text Add to dashboard Cite

Background: To investigate whether preoperative short-term extracorporeal life support therapy in patients undergoing continuous-flow left ventricular assist device implantation has an impact on the outcome regarding survival and adverse events. Methods: Between January 2011 and May 2018, 100 consecutive patients received HeartMate II, HeartWare, or HeartMate III for end-stage heart failure. Mean age was 64.2 ± 10.3 years. Three patient groups were identified: without preoperative extracorporeal life support (non-extracorporeal life support group, n = 80), with preoperative extracorporeal life support due to postcardiotomy shock after conventional cardiac surgery (postcardiotomy shock group, n = 9), and with preoperative extracorporeal life support without previous surgery (non-postcardiotomy shock group, n = 11). The primary endpoint was overall survival after device implantation. Secondary endpoints were adverse events during the follow-up period. Results: Survival was significantly different between the groups (p < 0.05): 30-day, 6-month, and 1-year survival rates were 85%, 68%, and 61% for non-extracorporeal life support group; 44%, 22%, and 22% for postcardiotomy shock group; and 45%, 27%, and 24% for non-postcardiotomy shock group, respectively. Furthermore, in both extracorporeal life support groups (postcardiotomy shock and non-postcardiotomy shock), there were a higher incidence (p < 0.05) of postoperative right heart failure (30% vs 66.7% vs 54.5%), acute renal failure requiring dialysis (20% vs 77.8% vs 54.5%), and respiratory failure (31.3% vs 88.9% vs 81.8%). Conclusion: Continuous-flow left ventricular assist device implantation with prior extracorporeal life support appears to have a worse outcome regarding survival, right heart failure, renal and respiratory dysfunction (p < 0.05). Future studies have to be done to evaluate the outcome after extracorporeal life support bridge pre-left ventricular assist device, especially as ultima ratio in postcardiotomy shock patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of preoperative extracorporeal life support on left ventricular assist device outcomes: A comparative study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Many cardiovascular diseases (CVD) are associated with myocardial damage, and when untreated they eventually lead to severe myocardial dysfunction within a relatively short time. Clinically evident impairment of systolic myocardial performance predominantly results from the insufficient regeneration of cardiomyocytes (CMs) [ 1 ]. Currently available therapies are unable to replace lost CMs and largely irreversible cardiac dysfunction ensues.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Profile of Genes Regulating the Structural Organization of Porcine Atrial Cardiomyocytes during Primary In Vitro Culture

Nawrocki

Jopek

Kaczmarek

et al. 2022

Genes

View full text Add to dashboard Cite

Numerous cardiovascular diseases (CVD) eventually lead to severe myocardial dysfunction, which is the most common cause of death worldwide. A better understanding of underlying molecular mechanisms of cardiovascular pathologies seems to be crucial to develop effective therapeutic options. Therefore, a worthwhile endeavor is a detailed molecular characterization of cells extracted from the myocardium. A transcriptomic profile of atrial cardiomyocytes during long-term primary cell culture revealed the expression patterns depending on the duration of the culture and the heart segment of origin (right atrial appendage and right atrium). Differentially expressed genes (DEGs) were classified as involved in ontological groups such as: “cellular component assembly”, “cellular component organization”, “cellular component biogenesis”, and “cytoskeleton organization”. Transcriptomic profiling allowed us to indicate the increased expression of COL5A2, COL8A1, and COL12A1, encoding different collagen subunits, pivotal in cardiac extracellular matrix (ECM) structure. Conversely, genes important for cellular architecture, such as ABLIM1, TMOD1, XIRP1, and PHACTR1, were downregulated during in vitro culture. The culture conditions may create a favorable environment for reconstruction of the ECM structures, whereas they may be suboptimal for expression of some pivotal transcripts responsible for the formation of intracellular structures.

show abstract

“…Cardiovascular diseases are the most common cause of death worldwide. Coronary artery disease (CAD), manifested frequently by myocardial infarction and, subsequently, end-stage heart failure (HF), are still an unsolved clinical problems that focus the attention of the scientific world [1]. Unfortunately, young patients constitute a large group of those affected, and they should be the main group of interest in the search to find effective therapeutic options.…”

Section: Introductionmentioning

confidence: 99%

Expression Profile of Genes Encoding Proteins Involved in Regulation of Vasculature Development and Heart Muscle Morphogenesis—A Transcriptomic Approach Based on a Porcine Model

Nawrocki

Jopek

Zdun

et al. 2021

IJMS

View full text Add to dashboard Cite

Despite significant advances in treatment of acute coronary syndromes (ACS) many subjects still develop heart failure due to significantly reduced ejection fraction. Currently, there are no commonly available treatment strategies that replace the infarcted/dysfunctional myocardium. Therefore, understanding the mechanisms that control the regeneration of the heart muscle is important. The development of new coronary vessels plays a pivotal role in cardiac regeneration. Employing microarray expression assays and RT-qPCR validation expression pattern of genes in long-term primary cultured cells isolated form the right atrial appendage (RAA) and right atrium (RA) was evaluated. After using DAVID software, it indicated the analysis expression profiles of genes involved in ontological groups such as: “angiogenesis”, “blood vessel morphogenesis”, “circulatory system development”, “regulation of vasculature development”, and “vasculature development” associated with the process of creation new blood vessels. The performed transcriptomic comparative analysis between two different compartments of the heart muscle allowed us to indicate the presence of differences in the expression of key transcripts depending on the cell source. Increases in culture intervals significantly increased expression of SFRP2, PRRX1 genes and some other genes involved in inflammatory process, such as: CCL2, IL6, and ROBO1. Moreover, the right atrial appendage gene encoding lysyl oxidase (LOX) showed much higher expression compared to the pre-cultivation state.

show abstract

Therapy for Heart Failure: The Leipzig Approach

Cited by 4 publications

References 30 publications

Impact of preoperative extracorporeal life support on left ventricular assist device outcomes: A comparative study

Impact of preoperative extracorporeal life support on left ventricular assist device outcomes: A comparative study

Transcriptomic Profile of Genes Regulating the Structural Organization of Porcine Atrial Cardiomyocytes during Primary In Vitro Culture

Expression Profile of Genes Encoding Proteins Involved in Regulation of Vasculature Development and Heart Muscle Morphogenesis—A Transcriptomic Approach Based on a Porcine Model

Contact Info

Product

Resources

About