Therapy of Antimicrobial-Resistant Typhoid Fever

Butler, Thomas; Linh, Nguyễn Ngọc; Arnold, Keith; Adickman, Michael; Chau, Duong Minh; Muoi, Mach Muoi

doi:10.1128/aac.11.4.645

Cited by 31 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of ceftriaxone and other newer cephalosporins in typhoid fever will be in disease due to multiply resistant strains of S. typhi [23]. From studies of ampicillinresistant Salmonella, it can be predicted that certain cephalosporins, including ceftriaxone, cefotaxime, and cefoxitin, will have good therapeutic activity, because they are more stable in the presence of 13-lactamase than are other cephalosporins [24].…”

Section: Discussionmentioning

confidence: 99%

Randomized Treatment of Patients with Typhoid Fever by Using Ceftriaxone or Chloramphenicol

Islam

Butler²,

Nath³

et al. 1988

Journal of Infectious Diseases

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Randomized Treatment of Patients with Typhoid Fever by Using Ceftriaxone or Chloramphenicol

Islam

Butler²,

Nath³

et al. 1988

Journal of Infectious Diseases

View full text Add to dashboard Cite

“…Dose-related and reversible bone marrow depression and irreversible bone marrow aplasia that is rare, unpredictable, and often fatal may occur (448). Amoxicillin and trimethoprim-sulfamethoxazole were shown to have efficacy generally comparable to that of chloramphenicol with less risk of toxicity, although they also needed to be given for at least 2 weeks to avoid relapse (439,(449)(450)(451)(452)(453)(454)(455)(456). The experience with mecillinam was less convincing (456)(457)(458).…”

Section: Traditional First-line Antimicrobialsmentioning

confidence: 99%

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

et al. 2015

View full text Add to dashboard Cite

SUMMARY Salmonella enterica infections are common causes of bloodstream infection in low-resource areas, where they may be difficult to distinguish from other febrile illnesses and may be associated with a high case fatality ratio. Microbiologic culture of blood or bone marrow remains the mainstay of laboratory diagnosis. Antimicrobial resistance has emerged in Salmonella enterica , initially to the traditional first-line drugs chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole. Decreased fluoroquinolone susceptibility and then fluoroquinolone resistance have developed in association with chromosomal mutations in the quinolone resistance-determining region of genes encoding DNA gyrase and topoisomerase IV and also by plasmid-mediated resistance mechanisms. Resistance to extended-spectrum cephalosporins has occurred more often in nontyphoidal than in typhoidal Salmonella strains. Azithromycin is effective for the management of uncomplicated typhoid fever and may serve as an alternative oral drug in areas where fluoroquinolone resistance is common. In 2013, CLSI lowered the ciprofloxacin susceptibility breakpoints to account for accumulating clinical, microbiologic, and pharmacokinetic-pharmacodynamic data suggesting that revision was needed for contemporary invasive Salmonella infections. Newly established CLSI guidelines for azithromycin and Salmonella enterica serovar Typhi were published in CLSI document M100 in 2015.

show abstract

“…This experimental disease has therefore been well accepted for studies on the in vivo efficacy of chemotherapeutic drugs (1,5,6,38). S. typhimurium is considered to be a facultative intracellular bacterium in the mouse, because the organisms multiply within macrophages until T-cell-mediated immunity is established during the course of the infection (8,16,23).…”

mentioning

confidence: 99%

“…Therapeutic trials. The model of mouse typhoid has been described in detail previously (1,5,6,8,23,34,38,40). Mice were infected subcuitaneously or orally with lethal doses of the virulent strain of S. typhimurium.…”

mentioning

confidence: 99%

Oral ciprofloxacin treatment for Salmonella typhimurium infection of normal and immunocompromised mice

Brünner

Zeiler

1988

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Oral treatment of Salmonella typhimurium infection with ciprofloxacin was compared with conventional chemotherapy with ampicillin or chloramphenicol in normal (CFW1) and immunocompromised (C57BL/6) mice. Administration of the antibiotics for 12 days reduced the number of bacteria in livers and the mortality of C57BL/6 mice significantly. Ciprofloxacin was considerably more effective than ampicillin in prolongation of the mean survival time of these mice. Similar to conventional chemotherapeutic agents, ciprofloxacin did not prevent fatal disease in most C57BL/6 mice when the treatment lasted 12 days only. On the other hand, ciprofloxacin cured lethal S. typhimurium illness in immunocompromised mice after long-term oral chemotherapy for 26 days at a dosage of 100 mg/kg twice a day. This was not achieved by either ampicillin or chloramphenicol. In normal mice, 12 days of therapy with ciprofloxacin was sufficient for a significant decrease in both the number of viable bacteria in livers and the mortality of lethally infected mice. The results provide a basis for an alternative antibiotic treatment by the oral route in immunocompromised hosts with systemic infections.

show abstract

Therapy of Antimicrobial-Resistant Typhoid Fever

Cited by 31 publications

References 36 publications

Randomized Treatment of Patients with Typhoid Fever by Using Ceftriaxone or Chloramphenicol

Randomized Treatment of Patients with Typhoid Fever by Using Ceftriaxone or Chloramphenicol

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

Oral ciprofloxacin treatment for Salmonella typhimurium infection of normal and immunocompromised mice

Contact Info

Product

Resources

About