Therapy of psoriasis in childhood and adolescence ‐ a German expert consensus

Abstract

Psoriasis of childhood shows an annual prevalence of 0.71 % and accordingly has to be regarded as a frequent chronic inflammatory skin disorder of this age. The impact on the quality of life as well as development of the afflicted children and their parents is evident. On the other side, therapy is demanding with regard to the specific juvenile metabolism, physical development and skin penetration of topical drugs. Long-term treatment at an early age has to be critically judged regarding the chronicity of the disease. Topical corticosteroids, alternatively dithranol may be used first-line, followed by vitamin D derivatives. A combination with UV-light, preferably UV-B, has to be decided on an individual basis. Systemic treatment may be initiated in recalcitrant disease with methotrexate and cyclosporine where long-term experience is available from juvenile rheumatology and transplantation medicine. Alternatively fumaric acid esters or retinoids are available. Rehabilitation procedures will help the children and their parents to cope with the disease and its treatment. The different treatment options are presented here as a German expert consensus, as clinical studies are hardly available and only a few therapeutics are licensed for this age. In any case the therapy has to be individually planned and decided together with the patients and their parents to gain maximal safety, comfort and success

The Retrospective Evaluation of Childhood Psoriasis Clinically and Demographic Features

“…Çocukluk çağında psoriasis tedavisinde topikal ve sistemik tedaviler kullanılmaktadır (1,19). Oniki yaş altında psoriasis vulgaris tedavisi için FDA tarafından özel olarak onaylanmış herhangi bir topikal ajan yoktur (1).…”

Çocuklarda Dermatolojik Hastalıklarda Yaşam Kalitesi

“…Erken başlangıç kötü prognoz ile ilişkilidir 52 . Çocukluk ve ergenlik döneminde psoriasis ciddi emosyonel sıkıntıya yol açabilir ve sağlıkla ilişkili yaşam kalitesini bozabilir 53 . Psoriasisli çocuk hastalarda yaşam kalitesi ile ilgili yapılmış olan araştırmalara ait bilgiler Tablo 2'de yer almaktadır.…”

Psoriasis Vulgaris: An Evidence-Based Guide for Primary Care

“…It can be used with caution in both children and adults because it can cause contact dermatitis if left on too long or if rubbed in the eyes or on the genital area. 35 Anthralin is usually left on for 5 to 20 minutes then washed off to avoid brown discoloration of clothing. Anthralin can be compounded with salicylic acid for stability.…”