There is an association between serum high-sensitivity C-reactive protein (hs-CRP) concentrations and depression score in adolescent girls

Tabatabaeizadeh, Seyed‐Amir; Abdizadeh, Mojtaba Fattahi; Meshkat, Zahra; Khodashenas, Ezzat; Darroudi, Susan; Fazeli, Mostafa; Ferns, Gordon A.; Avan, Amir; Ghayour‐Mobarhan, Majid

doi:10.1016/j.psyneuen.2017.11.014

Cited by 45 publications

(33 citation statements)

References 16 publications

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“…Unlike other studies 61,62 , we also did not prove a significant association of depressive symptomatology with hs-CRP, another factor associated with obesity. However, our results might be influenced by the fact that hs-CRP values were only available in a minor part of women, and predominantly healthy participants.…”

Section: Discussioncontrasting

confidence: 99%

Testosterone imbalance may link depression and increased body weight in premenopausal women

et al. 2019

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Accumulating evidence supports a link between depression and being overweight in women. Given previously reported sex differences in fat accumulation and depression prevalence, as well as the likely role of sex hormones in both overweight and mood disorders, we hypothesised that the depression-overweight association may be mediated by sex hormones. To this end, we investigated the association of being overweight with depression, and then considered the role of sex hormones in relation to being overweight and depression in a large population-based cohort. We included a total of 3124 women, 970 premenopausal and 2154 postmenopausal from the LIFE-Adult cohort study in our analyses. We evaluated associations between being overweight (BMI >25 kg/m 2 ), sex hormone levels, and depressive symptomatology according to Centre for Epidemiologic Studies Depression (CES-D) scores, and explored mediation of depression in a mediation model. Being overweight was significantly associated with depressive symptoms in premenopausal but not postmenopausal women. Both premenopausal and postmenopausal overweight women had higher free testosterone levels compared with normal weight women. Premenopausal women with depressive symptomatology had higher free testosterone levels compared to women without. We found a significant mediation effect of depressive symptomatology in overweight premenopausal women through free testosterone level. These findings highlight the association between being overweight and depressed, and suggest that high free testosterone levels may play a significant role in depression of overweight premenopausal women. Based on this, pharmacological approaches targeting androgen levels in overweight depressed females, in particular when standard anti-depressive treatments fail, could be of specific clinical relevance.

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Section: Discussioncontrasting

confidence: 99%

Testosterone imbalance may link depression and increased body weight in premenopausal women

et al. 2019

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“…We found that the association between depression/anxiety symptoms and serum PAB values were stronger among men than in women. We have previously shown that the relationship between depression/anxiety symptoms and inflammatory markers such as hs-CRP, WBC count, and RDW is stronger among men than in women (Shafiee et al, 2017;Tabatabaeizadeh et al, 2018;Tayefi et al, 2017). This weaker association in women may be partly explained by antioxidant (Sugioka et al, 1987) and anti-inflammatory (Vegeto et al, 2008) properties of estrogen in premenopausal women.…”

Section: Discussionmentioning

confidence: 96%

Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: A population-based study

Shafiee

Ahmadnezhad

Tayefi

et al. 2018

Journal of Affective Disorders

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“…Stress promotes the inflammatory response and affects the HPA axis, leading to anti-inflammatory regulation [12, 18, 23]. There have been many studies on the relationship between depression and inflammation, and the relationship is thought to be complex and interactive [14, 15, 17, 19]. In particular, depression associated with increased inflammation is correlated with suicidal ideation and attempts [10, 11, 18, 24].…”

Section: Introductionmentioning

confidence: 99%

Associations among inflammation, mental health, and quality of life in adults with metabolic syndrome

Kim

Song

2018

Diabetol Metab Syndr

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BackgroundMetabolic syndrome (MetS), a pro-inflammatory state, has become increasingly common worldwide and is a major risk factor for type 2 diabetes mellitus and cardiovascular disease. Recently, studies on the relationships among inflammation, mental health, quality of life, and other diseases have been conducted.MethodsWe investigated the relationship between serum high-sensitivity C-reactive protein (hs-CRP) levels, as an indicator of inflammation, and the quality of life and psychiatric symptoms of Korean adults with MetS. The analysis used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians conducted from January to December 2015. Data from 1600 participants were analyzed in this study. Quality of life was assessed using the EuroQol 5-dimension (EQ-5D) instrument.ResultsSerum hs-CRP levels showed a significant inverse correlation with the EQ-5D index of the overall quality of life. High serum hs-CRP levels were positively associated with mobility problems and suicidal ideation in adults with MetS (multivariate-adjusted odds ratio [OR] 1.66, 95% confidence interval [CI] 1.03–2.66, p = 0.036; and multivariate-adjusted OR 2.48, 95% CI 1.23–4.99, p = 0.011).ConclusionsThese findings suggest that the elevated inflammatory status in MetS is associated with decreased quality of life and mental health problems. Further prospective studies are needed to confirm the impact of inflammation on the quality of life and mental health of adults with MetS.

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There is an association between serum high-sensitivity C-reactive protein (hs-CRP) concentrations and depression score in adolescent girls

Cited by 45 publications

References 16 publications

Testosterone imbalance may link depression and increased body weight in premenopausal women

Testosterone imbalance may link depression and increased body weight in premenopausal women

Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: A population-based study

Associations among inflammation, mental health, and quality of life in adults with metabolic syndrome

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