There is no association between vitamin D status and characteristics of central precocious puberty in girls

Bénazé, Gwénaëlle Duhil de; Brauner, Raja; Souberbielle, Jean‐Claude

doi:10.1007/s00431-017-3022-9

Cited by 13 publications

(15 citation statements)

References 12 publications

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“…In addition, one study demonstrated an inverse association between BMI and WHR with serum vitamin D levels (15). However, our results demonstrated no correlation between vitamin D and either BMI or WHR in the women with PCOS; this may be related to the large heterogeneity with regard to vitamin D levels in relation to small sample size, the use of BMI to indicate adiposity, the small number (6) of women with vitamin D deficiency in the PCOS group, and methodological differences in measuring vitamin D. In line with these findings, in a few studies in which BMI was measured, no association with vitamin D deficiency in young patients with PCOS was reported (34,35). A study that used dual-energy X-ray absorptiometry (DEXA) to measure fat mass, abdominal fat mass, and fat-free mass in patients with PCOS and measured the correlation of BMI with vitamin D; reported that although their PCOS and control groups had similar adiposity levels, vitamin D levels were lower in the PCOS group (36).…”

Section: Discussionmentioning

confidence: 93%

Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

Bindayel

2021

Front. Nutr.

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. In this study, serum 25-hydroxyvitamin D levels were compared between women with and without PCOS and with regard to anthropometric indices and lipid and glucose biomarkers. Thirty-one women with PCOS and 75 controls answered a questionnaire on vitamin D, in addition to general health and lifestyle. The patients with PCOS had lower vitamin D levels (p < 0.05), a significantly higher rate of obesity (p < 0.05), and significantly higher serum triglyceride levels than did controls. The number of patients with PCOS consumed milk and dairy products (p < 0.05) and exposed to sun (p < 0.006) were lower compared to controls. Triglyceride levels were significantly correlated with body mass index (BMI); vitamin D level was not significantly correlated with anthropometrical or biochemical variables. These results affirm that vitamin D levels are lower in women with PCOS; however, despite the significantly higher proportion of obesity among patients with PCOS, hypovitaminosis was not associated with BMI. The relationship between body composition and vitamin D in PCOS and the effect of vitamin D correction on metabolic and hormonal parameters associated with PCOS must be assessed in future trials.

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Section: Discussionmentioning

confidence: 93%

Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

Bindayel

2021

Front. Nutr.

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“…In the PCOS patients Vit D correlated negatively with FSH, but the correlation was not statistically significant (38). In an earlier study Zolkova et al (39) had shown that there was an improvement in FSH level with specific doses of Vit D. However, a recent report failed to show any correlation between Vit D and FSH and LH in young females (40).…”

Section: Discussionmentioning

confidence: 96%

“…D and BMI, though earlier investigations showed that Vit D associates with BMI (10, 11, 13). Recently, Duhil de Benaze (40) also failed to show any association between Vit D and BMI.…”

Section: Discussionmentioning

confidence: 99%

Polymorphic Variations in VDR Gene in Saudi Women with and Without Polycystic Ovary Syndrome (PCOS) and Significant Influence of Seven Polymorphic Sites on Anthropometric And Hormonal Parameters

Thomali

Daghestani

et al. 2018

Journal of Medical Biochemistry

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SummaryBackgroundThis study was designed to evaluate the associations between vitamin D receptor (VDR) gene polymorphisms and biochemical characteristics of Saudi women with polycystic ovary syndrome (PCOS).MethodsSerum levels of LH, FSH, and Vitamin D were measured in 33 women: 16 patients and 17 normal controls (18 to 36 years). DNA was extracted and used for sequencing of the exons of VDR gene using ABI PRISM 3730xi Genetic Analyzer.ResultsWeight, BMI, Vit D, LH and FSH levels were higher in the PCOS patients compared to control group, where Vit D level correlated positively and significantly with FSH, in the control, but showed a negative and non-significant correlation in the PCOS patients. Sequencing results showed extensive polymorphisms in both groups, but the differences in the frequencies were not significant. Demographic and hormonal parameters were compared in the different genotypes of the SNPs. Significant differences were ob served in the values of the studied parameters in rs11168276, rs11168266, rs3858733, rs121909790, rs11168265 and rs731236. Vitamin D level was influenced significantly by the genotypes of rs11168265 (AA) (p=0.008), rs11168276 (AA; p=0.018) and rs731236 (CC; p=0.024).ConclusionVitamin D deficiency does not associate with PCOS in Saudi females. Several SNPs are identified in the VDR gene, in normal and PCOS females, but there is no difference in their frequencies between the two groups. The results show that polymorphism in VDR gene influences certain anthropometric and hormonal parameters in PCOS patients. Further detailed studies are required to confirm the associations between VDR and PCOS.

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“…In this case, there was su cient homogeneity in the seasonal distribution among the participants included in this study (CPP and control groups). However, previous studies that evaluated a possible association between vitamin D status and timing of puberty in girls have several limitations, since they either did not refer to race or season of the year in which the sample was collected [12][13][14], or did not include a group control [15]. In other words, this study allows us to analyze the results obtained avoiding confounding factors.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status and Parathyroid Hormone Levels in Girls With Central Precocious Puberty

Durá-Travé¹,

Gallinas-Victoriano²,

Ahmed-Mohamed³

et al. 2021

Preprint

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The objective of this study was to analyze the vitamin D status and PTH levels in 6- to 8-years-old girls with central precocious puberty. A cross-sectional clinical and blood testing (calcium, phosphorus, 25(OH)D and PTH) were carried out in 78 girls with central precocious puberty (CPP group), aged 6.1-7.9 years. A control group was recruited (157 prepubertal girls, aged 6.1-8.2 years). The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D. There were no significant differences in the vitamin D status between both groups. There were not significant differences in 25(OH)D levels between CPP (25.4±8.6 ng/mL) and control groups (28.2±7.4 ng/mL). In contrast, in CPP group PHT levels (44.8±16.3 pg/mL) were higher (p < 0.05) with respect to control group (31.0±11.9 ng/mL). In CPP group there was positive correlation (p < 0.05) between PTH levels and growth rate, bone age, basal estradiol, basal FSH, basal LH and LH peak. Conclusion: Vitamin D status in 6- to 8-years-old girls with CPP is similar to that in prepubertal girls. PTH levels were significantly higher in girls with CPP, and could be considered as a pubertal characteristic and, in this case, of pubertal precocity.

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There is no association between vitamin D status and characteristics of central precocious puberty in girls

Cited by 13 publications

References 12 publications

Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

Polymorphic Variations in VDR Gene in Saudi Women with and Without Polycystic Ovary Syndrome (PCOS) and Significant Influence of Seven Polymorphic Sites on Anthropometric And Hormonal Parameters

Vitamin D Status and Parathyroid Hormone Levels in Girls With Central Precocious Puberty

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