There is no difference in the disease severity of gastro‐oesophageal reflux disease between patients infected and not infected with Helicobacter pylori

Abstract

SUMMARYBackground: The role of Helicobacter pylori in gastrooesophageal reflux disease (GERD) is controversial. Aim: To compare the severity of GERD in infected vs. non-infected patients, as part of an ongoing randomized controlled trial that examines the impact of H. pylori eradication on GERD-related outcomes. Methods: Consecutive GERD patients underwent urea breath testing and completed validated GERD symptom severity, and quality of life questionnaires as well as, 24-h pH-metry. These parameters, as well as demographics and endoscopic findings were assessed in double-blinded fashion and compared between H. pylori-infected and non-infected subjects.

Minimal change oesophagitis: a disease with characteristic differences to erosive oesophagitis

“…Recently, Fallone et al . reported that there is no difference in disease severity of GERD between patients infected and not infected with H. pylori 18 . On the contrary, Haruma et al .…”

“…Recently, Fallone et al reported that there is no difference in disease severity of GERD between patients infected and not infected with H. pylori. 18 On the contrary, Haruma et al reported that age-correlated decrease of gastric acid secretion in H. pylori-positive subjects depended on an increasing prevalence of fundic atrophic gastritis with age. 19 In this study, H. pylori infection in the stomach was not examined, but the severity of gastric atrophy was assessed endoscopically.…”

“…Among 606 patients, 18 , 249 (71.8%) were minimal change oesophagitis (grade M) and 10 (2.8%) had normal findings. Two of 10 patients with endoscopic normal findings were symptomatic; thus they were regarded as grade N in the modified LA classification.…”

Helicobacter pylori and gastroesophageal reflux disease

“…1), and only a small subset of infected patients with GERD have corpus-predominant gastritis or gastric atrophy with impaired acid secretion. In patients with established GERD, no differences in esophageal acid exposure have been observed between H. pylori-positive and H. pylori-negative patients [30,31]. In Asia and Japan, where corpus-predominant and atrophic gastritis associated acid hyposecretion is more prevalent (Fig.…”

Helicobacter pyloriand gastroesophageal reflux disease: a review of this intriguing relationship

“…found no differences in the severity of GERD between individuals with and those without H. pylori infection. However, they did not evaluate for the presence of CagA‐positive strains or the degree of reflux esophagitis 36 …”