Thermal analysis and compatibility studies of prednicarbate with excipients used in semi solid pharmaceutical form

Neto, Hélio Salvio; Novák, Cs.; Matos, J. R.

doi:10.1007/s10973-009-0234-x

Cited by 52 publications

(18 citation statements)

References 11 publications

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“…Diffraction peak characteristics of prednicarbate crystals or other crystalline phase were not observed for the drug-loaded material, indicating that no crystallization process occurred to the molecules adsorbed inside the pores [5,8,10,53]. The DSC curve of the drug-loaded sample did not display an endothermic event between 175 and 200°C, which is the characteristic of the melting of the drug crystal [21] (Fig. 7); this also indicated the inexistence of any crystalline drug phase after the loading process [53].…”

Section: Characterization Of the Materialsmentioning

confidence: 92%

“…Purified water used as component of the receiving fluid and for chromatographic analysis was obtained from a Milli-Q Integral Water Purification system (EMD Millipore). The excipients of the placebo formulation were listed in Neto et al [21]. The placebo formulation, a cream of low viscosity and white color, was donated by Stiefel Laboratories Ltd., Brazil.…”

Section: Methodsmentioning

confidence: 99%

“…Prednicarbate is a non-halogenated corticosteroid, double-ester derivative of prednisolone, practically insoluble in water and with high anti-inflammatory activity. It has been widely used for the treatment for atopic dermatitis in patients whose risk/benefit ratio is high [21], despite its potential to cause severe adverse events, especially during chronic use [22][23][24][25][26][27]. Thus, the development of a silica-based system for this drug can increase its chemical stability and provide a better release profile and minimize its metabolism by the cutaneous esterases, potentially resulting in a longer therapeutic action and reduction in the daily dose, and consequently decrease frequency of adverse events such as skin thinning [25,28].…”

Section: Introductionmentioning

confidence: 99%

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Inclusion of prednicarbate in the SBA-15 silica

Neto

Araujo

Santos

et al. 2015

J Therm Anal Calorim

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The present work describes the development and characterization of a nanostructured mesoporous SBA-15 silica loaded with prednicarbate, a corticosteroid widely used in the treatment for atopic dermatitis, and the assessment of its in vitro release profile in comparison with a conventional cream formulation. The inclusion of prednicarbate in the SBA-15 pores was confirmed by the respective 24 and 16 % decrease in the surface area (S BET ) and mesopores volume (V), in combination with supporting data obtained by thermal analysis (TG and DSC), FTIR spectroscopy, X-ray diffraction, and elemental analysis. Additionally, it has been shown through X-ray diffraction and DSC that the encapsulated molecules remain in an amorphous state, and the protective function of the loading was demonstrated through thermogravimetry by the decrease in the rate of the thermal decomposition reaction of the drug-loaded material (Dm 600-850°C ). Finally, the HPLC-MS/MS method developed was proven to be precise and accurate for the determination of prednicarbate in the receiving fluid samples collected during the in vitro release test using Franz diffusion cells.

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Section: Characterization Of the Materialsmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inclusion of prednicarbate in the SBA-15 silica

Neto

Araujo

Santos

et al. 2015

J Therm Anal Calorim

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“…Thermal methods of analysis has been widely used in the coordination chemistry and in the pharmaceutical field to study solid state reactions [10], polymorphism [11], thermal stability [12], drug formulations [13], purity [14], reaction kinetics [15], evolved gas analysis by coupled TG-FTIR [16,17] and other properties of solid compounds used in pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen

et al. 2016

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a b s t r a c tSolid-state [La(Nap) 3 (H 2 O)], in which Nap is naproxen have been synthesized. Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), elemental analysis, complexometric titration, middle (MIR) and near (NIR) infrared region spectroscopy were used to characterize this compound and confirm the proposed stoichiometry. The experimental results provided information concerning the chemical composition, dehydration, coordination modes of the ligand, crystallinity of the sample, thermal behavior, thermal decomposition and polymorphism. Theoretical calculations helped in the assignment of the MIR vibrational bands and in the understanding of the coordination mode of the ligands. Cyclic DSC and XRD in different temperatures demonstrated that the complex presents five temperature dependent polymorphic forms. MIR spectroscopy suggest that the naproxen coordinates through the carboxylate group as a chelating ligand.[La(Nap) 3 (H 2 O)] showed lower cell cytotoxicity in comparison to naproxen. The compound increased the production of pro-inflammatory metabolites, such as TNF-␣, IL-1␤ and H 2 O 2 , and decreased an IL-8 level, that interferes in the trafficking of inflammatory cells.

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“…The thermal methods are extremely versatile, allowing useful characterization of almost any sample. The methods may be used to study single or multiple component systems such as finished dosage forms, although care is required in the interpretation of data from the latter [7][8][9].…”

Section: Introductionmentioning

confidence: 99%