Physico-chemical solid-state characterization of pharmaceutical pyrazolones: An unexpected thermal behaviour

Screening and characterization of cocrystal formation between carbamazepine and succinic acid

“…The importance of thermal analysis and spectroscopic description of pharmaceuticals [16][17][18][19] and potential bioactive derivatives [20][21][22][23], as well as in screening the cocrystal formation [24,25], is revealed by already published results. Following these considerations, we aimed in this study to obtain and characterize a new pharmaceutical cocrystal containing CBZ as active pharmaceutical ingredient and SA as coformer by the means of TG/DTG/HF techniques, FTIR spectroscopy and PXRD data.…”

Selection of solid-state excipients for simvastatin dosage forms through thermal and nonthermal techniques

“…The presence of excipients can induce in solid formulation, mainly physical and chemical interactions, while in vivo can lead to physiological ones [9]. Several instrumental techniques were employed in the analysis of newly obtained derivatives [10], but as well in evaluation of compatibility/incompatibility of active pharmaceutical ingredients (API) with excipients, namely thermoanalytical ones [11][12][13], FTIR spectroscopy [14], DSC [15] and XRD [16]. For a complete understanding of solid-state stability and decomposition, kinetic analysis can be performed on both bioactive/potentially bioactive molecules [17][18][19][20].…”

Pharmaceutical load in sewage sludge and biochar produced by hydrothermal carbonization

“…Otherwise, chemically similar compounds, which could also occur in sewage sludge, like aminophenazone, salipyrine or metamizole might degrade to phenazone. Further on, a high thermal stability up to 300°C of phenazone, which was reported by Fulias et al (2013) in thermogravimetric analysis, hinders subsequent degradation reactions.…”

“…Pharmaceuticals show a wide range of thermal stability. Reported decomposition temperatures of the investigated compounds vary from 190°C for ibuprofen (Zayed et al, 2012) to more than 300°C for phenazone (Fulias et al, 2013). The range corresponds to the common HTC temperature of 200-250°C.…”