Thermal analysis, antimicrobial and antioxidant studies of thiosemicarbazone derivatives

Pitucha, Monika; Ramos, Paweł; Wojtunik-Kulesza, Karolina; Głogowska, Agnieszka; Stefańska, Joanna; Kowalczuk, Dorota; Drozd, Monika; Augustynowicz–Kopeć, Ewa

doi:10.1007/s10973-023-12029-z

Cited by 12 publications

(9 citation statements)

References 30 publications

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“…( Figure 6 and Figure S3 , Table 6 ). This stage is associated with water loss [ 23 , 45 ]. The second stage occurred in the temperature range of 391.7 °C to 409.2 °C, with a maximum peak of 396.7 °C.…”

Section: Resultsmentioning

confidence: 99%

“…These methods have shown their usefulness in our previous studies for the identification of single- and dual-component preparations containing theophylline [ 18 ]. In addition, other authors have demonstrated their usefulness in the pharmaceutical industry for the identification of polymorphic substances [ 19 , 20 ], the influence of ambient relative humidity on vapor sorption [ 21 ], thermal stability [ 22 , 23 ], or compatibility of excipients with API [ 24 , 25 , 26 , 27 ] and API with API [ 28 ], as well as quality control in pharmacies [ 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations

Ramos,

Raczak,

Silvestri

et al. 2023

Pharmaceutics

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Naproxen is one of the most used non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat pain of various origins, inflammation and fever. Pharmaceutical preparations containing naproxen are available with prescription and over-the-counter (OTC). Naproxen in pharmaceutical preparations is used in the form of acid and sodium salt. From the point of view of pharmaceutical analysis, it is crucial to distinguish between these two forms of drugs. There are many costly and laborious methods to do this. Therefore, new, faster, cheaper and, at the same time, simple-to-perform identification methods are sought. In the conducted studies, thermal methods such as thermogravimetry (TGA) supported by calculated differential thermal analysis (c-DTA) were proposed to identify the type of naproxen in commercially available pharmaceutical preparations. In addition, the thermal methods used were compared with pharmacopoeial methods for the identification of compounds, such as high-performance liquid chromatography (HPLC), Fourier-transform infrared spectroscopy (FTIR), UV-Vis spectrophotometry, and a simple colorimetric analyses. In addition, using nabumetone, a close structural analog of naproxen, the specificity of the TGA and c-DTA methods was assessed. Studies have shown that the thermal analyses used are effective and selective in distinguishing the form of naproxen in pharmaceutical preparations. This indicates the potential possibility of using TGA supported by c-DTA as an alternative method.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations

Ramos,

Raczak,

Silvestri

et al. 2023

Pharmaceutics

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“…The compound with the strongest antituberculosis activity, T69, showed 4 /cm 3 activity against M. tuberculosis H37Rv (Standard Isonicotinic acid hydrazide: 0.125 /cm 3 ). Against other bacterial strains, T57 and T58 exhibited moderate activity with a MIC of 64-128 g/mL [23]. Rusnac and co-workers synthesized a paracetamol-containing thiosemicarbazone (T70) and its five Cu(II) complexes (T71-75) (Figure 9).…”

Section: Figurementioning

confidence: 99%

A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds

Korkmaz

2024

Journal of New Results in Science

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Thiosemicarbazones can be synthesized by condensation of thiosemicarbazides with ketones or aldehydes and play a role as precursors in the synthesis of many compounds such as thiazoles. They can exhibit many biological activities such as anti-inflammatory, antitumor, and antimicrobial properties. The discovery of antibiotics was an important milestone in the treatment of bacterial infections. However, antimicrobial resistance developed by microorganisms has created the need to discover new antimicrobial agents. Thiosemicarbazones and thiosemicarbazone-based compounds show significant antimicrobial potential. This review investigates the antimicrobial activity results of 244 Thiosemicarbazones and Thiosemicarbazone-based compounds over the last five years. We summarized some articles on thiosemicarbazones and their hybrids showing only antibacterial and antifungal activity in Web of Science (WOS) between 2019 and 2024.

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“…In isatinthiocarbohydrazones, the bending vibrations of ν(C−N) occur within the range of 1199-1173 cm -1 . The long-term stability of biodiesel samples is linked to low oxidation levels [54]. Antioxidants, particularly phenolic chemicals, have been found to enhance peak intensity, according to studies.…”

Section: Fourier Transform Infrared Spectroscopy (Ft-ir)mentioning

confidence: 99%

Antioxidant Properties of Biodiesel-Diesel Blends and Non-Isothermal Kinetic Studies of Schiff-Based Isatin-Thiosemicarbazone Derivatives

Karakullukcu,

Muglu,

Yakan

et al. 2024

Preprint

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Biodiesel has several drawbacks, such as being prone to oxidation, having reduced stability, and having limited storage time. Antioxidants compatible with biodiesel are being used to address its drawbacks. The use of antioxidants in biodiesel has a significant impact on the environment and economy, especially in promoting sustainable energy. The study used blends consisting of 20% biodiesel and 80% diesel fuel. Isatin-thiosemicarbazones were tested as additives in blends at a concentration of 3000 parts per million (ppm) using an oxifast device. Comparing them to the chemical antioxidant Trolox. FT-IR, DSC, and TGA were used to characterize these samples. DSC measured sample crystallization temperatures (Tc). Samples with antioxidants showed decreased values compared to the non-antioxidant diesel sample D100. Several DSC tests were conducted to determine the antioxidant strengths of various samples. The results showed that the FT-IR spectrum's antioxidant effect regions grow clearer with antioxidants. The extra antioxidant is effective. Biodiesel's oxidative stability improves with isatin-thiosemicarbazones at varying concentrations. The kinetics of thermal decomposition of isatin-thiosemicarbazones under non-isothermal conditions have been determined using the Kissinger, Ozawa, and Boswell techniques. The activation energies of compounds 1 and 2 were calculated 137–147 kJ mol-1 and 173–183 kJ mol-1, respectively.

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Thermal analysis, antimicrobial and antioxidant studies of thiosemicarbazone derivatives

Cited by 12 publications

References 30 publications

Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations

Application of TGA/c-DTA for Distinguishing between Two Forms of Naproxen in Pharmaceutical Preparations

A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds

Antioxidant Properties of Biodiesel-Diesel Blends and Non-Isothermal Kinetic Studies of Schiff-Based Isatin-Thiosemicarbazone Derivatives

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