The current research is focused on investigating the influence of bearing irregularities like eccentricities (ε), non-circularities (G), L/D ratio (β), surface roughness coefficient (Y) on hydrodynamic performance of journal bearing such as load bearing capacity, friction force, lubricating oil flow.The performance is evaluated through finite difference method technique implementing a Newton-Raphson method of error convergence. The simulation outputs were than designed using an optimization tool entitled as Design of Experiment (DoE) on basis of response surface methodology (RSM). The outputs of RSM models were meant to forecast the response parameters like, load bearing capacity, friction force, flow of lubricant and further required to identify the noticeable interdependencies within the input parameters while evaluating the lubrication performance. The optimization of the bearing irregularities is done considering desirability approach of the response surface methodology in identifying proper combination of parameters.