Thermal analysis of magnetic nanoparticle in alternating magnetic field on human HCT-116 colon cancer cell line

Attar, Mohammad Mahdi; Amanpour, Saeid; Haghpanahi, Mohammad; Haddadi, Mohammad; Rezaei, Gita; Muhammadnejad, Samad; HajiAkhoundzadeh, Mehran; Barati, Tahereh; Sadeghi, Fatemeh; Javadi, Saba

doi:10.1080/02656736.2016.1204667

Cited by 15 publications

(5 citation statements)

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“…Magnetic hyperthermia has been widely explored theoretically, and experimentally, to achieve therapeutic effects in cancer therapy, and the introduced magnetic particles exhibit great prospects in clinical application. , Considering that tumor cells are more sensitive to temperatures ranging from 40 to 48 °C than are normal cells, this temperature range has been adopted in most studies as the therapeutic temperature to avoid normal tissue damage. Nonetheless, it is important to consider that when the temperature is above 40 °C, the tissues can be ablated gradually. , Yet, the efficacy of MHT is restricted by tumor recurrence due to thermo-resistance arising from the up-regulation of heat shock proteins (HSPs) at therapeutic temperatures and overdosed administration of magnetic nanoparticles. Numerous synergistic modalities have been established to amplify the heat efficiency by combining with photothermal therapy, , photodynamic therapy, , radiotherapy, chemotherapy, and HSP inhibitors .…”

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confidence: 99%

“…Nonetheless, it is important to consider that when the temperature is above 40 °C, the tissues can be ablated gradually. 5,6 Yet, the efficacy of MHT is restricted by tumor recurrence due to thermo-resistance arising from the upregulation of heat shock proteins (HSPs) at therapeutic temperatures and overdosed administration of magnetic nanoparticles. Numerous synergistic modalities have been established to amplify the heat efficiency by combining with photothermal therapy, 7,8 photodynamic therapy, 9,10 radiotherapy, 11 chemotherapy, 12 and HSP inhibitors.…”

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confidence: 99%

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Hollow Magnetic Nanocatalysts Drive Starvation–Chemodynamic–Hyperthermia Synergistic Therapy for Tumor

et al. 2020

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Magnetic hyperthermia therapy (MHT) has been considered as an excellent alternative for treatment of deep tumor tissue; however, up-regulation of heat shock proteins (HSPs) impairs its hyperthermal therapeutic effect. Reactive oxygen species (ROS) and competitive consumption of ATP are important targets that can block excessive HSP generation. We developed a magnetic nanocatalytic system comprised of glucose oxidase (GOD)-loaded hollow iron oxide nanocatalysts (HIONCs) to drive starvation–chemodynamic–hyperthermia synergistic therapy for tumor treatment. The Fe2+ present in HIONCs contributed to ROS generation via the Fenton reaction, relieving thermo-resistance and inducing cell apoptosis by chemodynamic action. The Fenton effect was enhanced through the conditions created by increased MHT-related temperature, GOD-mediated H2O2 accumulation, and elevated tumor microenvironment acidity. The HIONCs catalase-like activity facilitated conversion of H2O2 to oxygen, thereby replenishing the oxygen levels. We further demonstrated that locally injected HIONCs-GOD effectively inhibited tumor growth in PC3 tumor-bearing mice. This study presents a multifunctional nanocarrier system driving starvation–chemodynamic–magnetic–thermal synergistic therapy via ROS and oxygen modulation for prostate tumor treatment.

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Hollow Magnetic Nanocatalysts Drive Starvation–Chemodynamic–Hyperthermia Synergistic Therapy for Tumor

et al. 2020

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“…For in vitro hyperthermia study, SKBR3 and fibroblast cells were seeded in the 96-well plates with the concentration of 5000 cells per well and 200 µL of fresh media was added. After 48 h of incubation, the media was replaced by 200 µL of fresh media containing optimum concentration of 80 µg/mL (Attar et al 2016 ) of three magnetic nanoparticle groups (MNP, DMNP and ADMNP). A control group with no magnetic substance was also considered for each cell type.…”

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confidence: 99%

Synthesis and application of magnetite dextran-spermine nanoparticles in breast cancer hyperthermia

et al. 2017

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Cancer treatment has been very challenging in recent decades. One of the most promising cancer treatment methods is hyperthermia, which increases the tumor temperature (41–45 °C). Magnetic nanoparticles have been widely used for selective targeting of cancer cells. In the present study, magnetic dextran-spermine nanoparticles, conjugated with Anti-HER2 antibody to target breast cancer cells were developed. The magnetic dextran-spermine nanoparticles (DMNPs) were prepared by ionic gelation, followed by conjugation of antibody to them using EDC-NHS method. Then the Prussian blue method was used to estimate the targeting ability and cellular uptake. Cytotoxicity assay by MTT showed that antibody-conjugated MNPs (ADMNPs) have no toxic effect on SKBR3 and human fibroblast cells. Finally, the hyperthermia was applied to show that synthesized ADMNPs, could increase the cancer cells temperature up to 45 °C and kill most of them without affecting normal cells. These observations proved that Anti-HER2 conjugated magnetic dextran-spermine nanoparticles can target and destroy cancer cells and are potentially suitable for cancer treatment.

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“…This consists of an inductor and capacitor connected either in series or in parallel [30]. Some studies have exploited combining a half-bridge circuit with a tank circuit [31,32] where the half-bridge is involved in switching electronic power in the tuned circuit.…”

Section: Induction Coil Circuit Designmentioning

confidence: 99%

Design and Modelling of an Induction Heating Coil to Investigate the Thermal Response of Magnetic Nanoparticles for Hyperthermia Applications

Drake,

Algaddafi,

Swift

et al. 2024

BioMedInformatics

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Magnetic Field Hyperthermia is a technique where tumours are treated through an increase in local temperature upon exposure to alternating magnetic fields (AMFs) that are mediated by magnetic nano-particles (MNPs). In an AMF, these particles heat-up and kill the cells. The relationship between an AMF and the heating-rate is complex, leading to confusion when comparing data for different MNP and AMF conditions. This work allows for the thermal-response to be monitored at multiple AMF amplitudes while keeping other parameters constant. An induction-heating coil was designed based on a Zero-Voltage-Zero-Current (ZVZC) resonant circuit. The coil operates at 93 kHz with a variable DC drive-voltage (12–30 V). NEC4 software was used to model the magnetic field distribution, and MNPs were synthesised by the coprecipitation method. The magnetic field was found to be uniform at the centre of the coil and ranged from 1 kAm−1 to 12 kAm−1, depending on the DC drive-voltage. The MNPs were found to have a specific absorption rate (SAR) of 1.37 Wg−1[Fe] and 6.13 Wg−1[Fe] at 93 kHz and 2.1 kAm−1 and 12.6 kAm−1, respectively. The measured SAR value was found to be directly proportional to the product of the frequency and field-strength (SARα f Ho). This leads to the recommendation that, when comparing data from various groups, the SAR value should be normalized following this relationship and not using the more common relationship based on the square of the field intensity (SARα f Ho2).

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Thermal analysis of magnetic nanoparticle in alternating magnetic field on human HCT-116 colon cancer cell line

Abstract: Our results demonstrate that where thermal dose is equal to 4.5 ± 0.5 °C/30 min from a starting temperature of 37 °C, HCT-116 cell death is initiated when a magnetic nanoparticle electromagnetic field induced.

Cited by 15 publications

References 31 publications

Hollow Magnetic Nanocatalysts Drive Starvation–Chemodynamic–Hyperthermia Synergistic Therapy for Tumor

Hollow Magnetic Nanocatalysts Drive Starvation–Chemodynamic–Hyperthermia Synergistic Therapy for Tumor

Synthesis and application of magnetite dextran-spermine nanoparticles in breast cancer hyperthermia

Design and Modelling of an Induction Heating Coil to Investigate the Thermal Response of Magnetic Nanoparticles for Hyperthermia Applications

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