Thermal analysis of pure and multisubstituted hydroxyapatite pastes

Forizs, E.; Goga, Firuţa; Avram, Alexandra; Mocanu, Aurora; Petean, Ioan; Horovitz, Ossi; Tomoaia-Cotişel, Maria

doi:10.24193/subbchem.2017.4.14

Cited by 13 publications

(13 citation statements)

References 20 publications

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“…The investigated HAP and substituted complex HAPs (HAPc-5%Sr and HAPc-10%Sr) were prepared as shown elsewhere [ 18 , 23 , 47 , 48 ]. Briefly, calcium nitrate, Ca(NO 3 ) 2 , and diammonium hydrogen phosphate, (NH 4 ) 2 HPO 4 , aqueous solutions in stoichiometric mole ratio Ca/P = 5/3, were the precursors for HAP, Ca 10 (PO 4 ) 6 (OH) 2, preparation, while ammonia solution was used to bring the pH to 11.5.…”

Section: Methodsmentioning

confidence: 99%

Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study

et al. 2021

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Multi-substituted hydroxyapatites (ms-HAPs) are currently gaining more consideration owing to their multifunctional properties and biomimetic structure, owning thus an enhanced biological potential in orthopaedic and dental applications. In this study, nano-hydroxyapatite (HAP) substituted with multiple cations (Sr 2+ , Mg 2+ and Zn 2+ ) for Ca 2+ and anion ( Si O 4 4 − ) for P O 4 3 − and OH − , specifically HAPc-5%Sr and HAPc-10%Sr (where HAPc is HAP-1.5%Mg–0.2%Zn–0.2%Si), both lyophilized non-calcined and lyophilized calcined, were evaluated for their in vitro ions release. These nanomaterials were characterized by scanning electron microscopy, field emission-scanning electron microscopy and energy-dispersive X-ray, as well as by atomic force microscope images and by surface specific areas and porosity. Further, the release of cations and of phosphate anions were assessed from nano-HAP and ms-HAPs, both in water and in simulated body fluid, in static and simulated dynamic conditions, using inductively coupled plasma optical emission spectrometry. The release profiles were analysed and the influence of experimental conditions was determined for each of the six nanomaterials and for various periods of time. The pH of the samples soaked in the immersion liquids was also measured. The ion release mechanism was theoretically investigated using the Korsmeyer–Peppas model. The results indicated a mechanism principally based on diffusion and dissolution, with possible contribution of ion exchange. The surface of ms-HAP nanoparticles is more susceptible to dissolution into immersion liquids owing to the lattice strain provoked by simultaneous multi-substitution in HAP structure. According to the findings, it is rational to suggest that both materials HAPc-5%Sr and HAPc-10%Sr are bioactive and can be potential candidates in bone tissue regeneration.

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Section: Methodsmentioning

confidence: 99%

Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study

et al. 2021

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“…The substituted elements can lead to beneficial effects on morphology, structure and mechanical properties. HAP can be used in bone tissue engineering, implant coating, dental materials and drug carriers [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67].…”

Section: Complexes With Nanostructured Materials (Hydroxyapatite)mentioning

confidence: 99%

Silymarin Based Complexes – a mini review

PALTINEAN¹,

Tomoaia²,

Riga³

et al. 2022

AnnalsARSciBio

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Silymarin (SIL) is a component extracted from Silybum marianum herb and is studied in medicine due to its protective activities on certain organs (liver, kidney, heart, brain). The review discusses some methods that increase silymarin bioavailability such as development of complexes with cyclodextrins, phospholipids, liposome and nanostructured material (hydroxyapatite-HAP). The interactions between SIL and alpha-lipoic acid, metallic nanoparticles (gold nanoparticles-GNP, and silver nanoparticles – SNP), some carotenoids (β-carotene and lycopene) and curcumin were debated too. Some combined treatments (e.g. SIL + curcumin) highlighted anticancer activity against colon cancer cells (DLD-1, HCT116 and LoVo) and protective effect against chemicals toxicity.

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“…The final precipitate was filtered and washed repeatedly with ultrapure water at room temperature until nitrates were removed. The drying process was performed by lyophilization followed by the calcination step at 300°C for one hour and the sample was disintegrated in a ball mill to obtain a fine powder [70][71][72][73].…”

Section: Ions Release From Hydroxyapatitementioning

confidence: 99%

“…A release of ions into water can be observed (Figure 3), for substituted hydroxyapatites, the amount of Ca released is higher than from pure HAP and very similar for all complex hydroxyapatites [71][72][73][74][75][76][77][78][79][80][81]. Multisubstituted hydroxyapatites with a long release of ions could be used as resorbable fillers for bone defects or even as coatings, as these particles could release ions for a longer period of time which can be beneficial for the formation of new bones.…”

Section: Ions Release From Hydroxyapatitementioning

confidence: 99%

Biomimetic and Antibacterial Composite for Orthopedic Implants

Balint¹,

Paltinean²,

FLOREA³

et al. 2022

AnnalsARSciBio

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The present paper shows how the development of synthetic nanostructured biomaterials, such as multisubstituted hydroxyapatite (msHAP) with Mg2+, Zn2+ and Sr2+ ions is important and beneficial at the same time for the normal functioning of the body. Moreover, the paper discusses a broad topic of major importance in orthopedic and dental surgery, namely the incorporation of msHAP into the polymeric matrix of poly lactic acid (PLA). This composite is used in order to cover the surface of the titanium implant in order to obtain bone integration and heal bone fractures. The review also highlights the importance of improving silver nanoparticle (SNPs) coating in order to combat postoperative infections. Through such approaches, medicine has managed to evolve considerably, and the contributions brought by great personalities and young researchers in the field have increased its area of applicability.

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Thermal analysis of pure and multisubstituted hydroxyapatite pastes

Cited by 13 publications

References 20 publications

Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study

Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids: in vitro experiments and theoretical modelling study

Silymarin Based Complexes – a mini review

Biomimetic and Antibacterial Composite for Orthopedic Implants

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