Thermal analysis of water in reinforced plasma-polymerised poly(2-hydroxyethyl acrylate) hydrogels

Serrano‐Aroca, Ãngel; Pradas, Manuel Monleón; Ribelles, J.L. Gómez; Rault, J.

doi:10.1016/j.eurpolymj.2015.05.032

Cited by 22 publications

(8 citation statements)

References 26 publications

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“…Alginate films, like most hydrophilic polymers, exhibit poor mechanical performance when they are hydrated at body temperature (~37 • C) in biomedical applications. Thus, the mechanical properties of these polymer networks can be improved following a broad range of established reinforcing methods developed for polymers: reinforcement by interpenetrating polymer networks (IPNs) [21], rise of crosslinking density [22,23], addition of nanofibers [24,25], plasma polymerization methods [26,27] and more recently, by the incorporation of low contents (up to 1% w/w) of CNMs such as 1D CNFs or 2D GO nanosheets [28][29][30][31][32][33]. In addition, this nanotechnological approach was able to enhance other physical and biological properties of calcium alginate films such as wettability, water diffusion [29,30] and antibacterial activity against the life-threatening methicillin-resistant Staphylococcus epidermidis [34,35].…”

Section: Introductionmentioning

confidence: 99%

Study of 1D and 2D Carbon Nanomaterial in Alginate Films

2020

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Alginate-based materials hold great promise in bioengineering applications such as skin wound healing and scaffolds for tissue engineering. Nevertheless, cell adhesion of mammalian cells on these hydrophilic materials is very poor. In cases such as polycaprolactone, poly(hydroxy-3-butyrate-co-3-valerate) and gelatin, the incorporation of hydrophobic carbon nanofibers (CNFs) and hydrophilic graphene oxide (GO) has shown significant improvement of cell adhesion and proliferation. The incorporation of these carbon nanomaterials (CNMs) into alginate films can enhance their mechanical performance, wettability, water diffusion and antibacterial properties. Herein, we report the effect of adding these CNMs into alginate films on cell adhesion for the first time. Thus, the results of this study showed that these nanocomposites are non-cytotoxic in human keratinocyte HaCaT cells. Nevertheless, contrary to what has been reported for other polymers, cell adhesion on these advanced alginate-based composites was not improved. Therefore, both types of composite films possess similar biological behavior, in terms of cell adhesion and non-cytotoxicity, and enhanced physical and antibacterial properties in comparison to neat alginate for potential biomedical and bioengineering applications.

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Section: Introductionmentioning

confidence: 99%

Study of 1D and 2D Carbon Nanomaterial in Alginate Films

2020

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“…There are copious methods available to enhance the properties of polymer scaffold such as block copolymer (where the wettability of the polymer scaffold can be manipulated by the optimized hydrophilic and hydrophobic domains) and cross-linking density (where the water sorption increases with cross-linking content if the cross-linking agent has a hydrophilic functional group; higher cross-linking density stabilizes the pore geometry while processing). − Mechanical properties and dynamic swelling behavior are manipulated by the encapsulating cells in the interpenetrating polymer networks . Cell adhesion and proliferation depend on the wettability of the scaffold, and it can be enhanced by plasma treatment. − The sol–gel method utilized for fabrication of nonbiodegradable scaffold possess high water uptake and good mechanical properties. , …”

Section: Introductionmentioning

confidence: 99%

Progress in the Advancement of Porous Biopolymer Scaffold: Tissue Engineering Application

Ambekar

Kandasubramanian

2019

Ind. Eng. Chem. Res.

165

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Tissue engineering is a derivative of biomedical engineering, which deals with the repair and regeneration of organs or their tissues. Cell-embedded porous polymeric scaffolds unveil proficiency in rectifying the mechanical trauma of skin, bone erosion, and neurodegenerative diseases like spinal cord injury. Archetypically, pristine cell-based biomaterial scaffolds are utilized; however, investigations over time have validated that incorporation of additives such as silver nanoparticles or bioactive glass augments antimicrobial characteristics in conjunction with cell adherence. An ideal scaffold should exhibit ease of processability, biocompatibility, biodegradability, noncytotoxicity, and excellent mechanical property, and these properties can be achieved with biodegradable polymers. Researchers have extensively explored copious advanced as well as conventional fabrication technologies such as electrospinning, 3D and 4D bioprinting, among others, for contouring of porous polymeric scaffolds in tissue-engineering functions like skin, bone, liver, cardiac, and neural tissue regeneration, which we have consolidated and discussed in the presented Review.

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“…However, calcium alginate, like most hydrogels, is very brittle [10], and is thus in need of reinforcing strategies to increase exponentially their potential applications. Thus, several methods to enhance the mechanical properties of hydrogels have been developed so far: reinforcement through copolymerisation with hydrophobic monomers [11], interpenetrating polymer networks (IPNs) [12], rise of cross-linking degree [13,14], double cross-linked networks [15], incorporation of nanofibre mats [16], self-sorting [17], plasma-induced polymerisation onto a hydrophobic porous polymer [18,19,20]. More recently, seemingly even more successful methods include the reinforcement of hydrogels by incorporation of carbon materials such as graphene oxide (GO) [21,22] and carbon nanofibers (CNFs) [23,24].…”

Section: Introductionmentioning

confidence: 99%

Low-Cost Advanced Hydrogels of Calcium Alginate/Carbon Nanofibers with Enhanced Water Diffusion and Compression Properties

Llorens-Gámez

Serrano‐Aroca

2018

Polymers

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A series of alginate films was synthesised with several calcium chloride cross-linker contents (from 3 to 18% w/w) with and without a very low amount (0.1% w/w) of carbon nanofibers (CNFs) in order to reduce the production costs as much as possible. The results of this study showed a very significant enhancement of liquid water diffusion and mechanical compressive modulus for high calcium chloride contents when this minuscule amount of CNFs is incorporated into calcium alginate hydrogels. These excellent results are attributed to a double cross-linking process, in which calcium cations are capable of cross-linking both alginate chains and CNFs creating a reinforced structure exhibiting ultrafast water diffusion through carbon nanochannels. Thus, these excellent results render these new alginate composites very promising for many bioengineering fields in need of low-cost advanced hydrogels with superior water diffusion and compression properties.

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Thermal analysis of water in reinforced plasma-polymerised poly(2-hydroxyethyl acrylate) hydrogels

Cited by 22 publications

References 26 publications

Study of 1D and 2D Carbon Nanomaterial in Alginate Films

Study of 1D and 2D Carbon Nanomaterial in Alginate Films

Progress in the Advancement of Porous Biopolymer Scaffold: Tissue Engineering Application

Low-Cost Advanced Hydrogels of Calcium Alginate/Carbon Nanofibers with Enhanced Water Diffusion and Compression Properties

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