Thermal analysis study of the interactions between acetaminophen and excipients in solid dosage forms and in some binary mixtures

Tomassetti, M.; Catalani, Alessia; Rossi, Verónica; Vecchio, Stefano

doi:10.1016/j.jpba.2004.10.008

Cited by 68 publications

(29 citation statements)

References 16 publications

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“…They are important in the studies of pre-formulation of drugs, because they allow the investigation of potential physical and chemical interactions between drugs and pharmaceutical adjuvants [7][8][9]. Few works are available that investigate the stability and the antioxidating property of this substance, used alone or in the presence of adjuvants.…”

Section: Introductionmentioning

confidence: 99%

Thermal Behavior and Free-Radical-Scavenging Activity of Phytic Acid Alone and Incorporated in Cosmetic Emulsions

et al. 2015

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Phytic acid is a natural compound widely used as depigmenting agent in cosmetic emulsions. Few studies are available in the literature covering the stability and the antioxidating property of this substance, used alone or into emulsions. Therefore, the purpose of this work was to investigate the thermal behavior and antioxidant properties of phytic acid alone and into cosmetic emulsions. The thermal behavior of this substance was evaluated by thermogravimetry (TG)/derivative thermogravimetry (DTG) and differential scanning calorimetry (DSC) and the free-radical-scavenging activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH). TG/DTG and DSC curves allowed evaluation of the thermal behavior of phytic acid. These results showed that the substance presented four stages of mass loss. Thermal decomposition of the material initiated at 150 °C. Thermal behavior of the cosmetic emulsions detected that the addition of phytic acid decreased the thermal stability of the system. DPPH free-radical-scavenging activity showed that phytic acid incorporated into emulsion had no antioxidant capacity compared to BHT. In summary, we concluded that the thermoanalytical techniques (TG and DSC) were efficient and reliable in the characterization of phytic acid alone and incorporated into cosmetic emulsions. OPEN ACCESSCosmetics 2015, 2 249

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Section: Introductionmentioning

confidence: 99%

Thermal Behavior and Free-Radical-Scavenging Activity of Phytic Acid Alone and Incorporated in Cosmetic Emulsions

et al. 2015

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“…Thermoanalytical techniques such as differential scanning calorimetry (DSC), thermogravimetry and derivative thermogravimetry (TG/ DTG), are extremely important in evaluating the stability and processes of thermal decomposition of materials, allowing their characterization, and have been used by pharmacists for over 30 years (Felix, Cides, Angnes, Matos, 2009). These techniques are important tools in the pre-formulation stage of medications, mainly because they allow the investigation of potential physical and chemical interactions between active principles and pharmaceutical adjuvants of a formula, thus allowing the prediction of possible incompatibilities in the final product (Araújo et al, 2003;Tomassetti et al, 2005;Giron, 1986).…”

Section: Introductionmentioning

confidence: 99%

“…In many cases, a more comprehensive understanding and interpretation of thermal processes requires a combination of results from thermal analysis with those obtained by other physico-chemical and analytical techniques, for example, results obtained by infrared absorption spectroscopy (IR), elemental analysis of C, H and N (EA), X-ray diffraction (XRD), and gas chromatography coupled with mass spectrometry (GC-MS) (Giron, 2002;Araújo et al, 2003;Tomassetti et al, 2005;Salvio Neto, Novak, Matos, 2009).…”

Section: Introductionmentioning

confidence: 99%

Study of thermal behavior of phytic acid

Daneluti

Matos

2013

Braz. J. Pharm. Sci.

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Phytic acid is a natural compound widely used as depigmenting agent in galenic cosmetic emulsions. However, we have observed experimentally that phytic acid, when heated to 150 o C for around one hour, shows evidence of thermal decomposition. Few studies investigating this substance alone with regard to its stability are available in the literature. This fact prompted the present study to characterize this species and its thermal behavior using thermal analysis (TG/DTG and DSC) and to associate the results of these techniques with those obtained by elemental analysis (EA) and absorption spectroscopy in the infrared region. The TG/DTG and DSC curves allowed evaluation of the thermal behavior of the sample of phytic acid and enabled use of the non-isothermal thermogravimetric method to study the kinetics of the three main mass-loss events: dehydration I, dehydration II and thermal decomposition. The combination of infrared absorption spectroscopy and elemental analysis techniques allowed evaluation of the intermediate products of the thermal decomposition of phytic acid. The infrared spectra of samples taken during the heating process revealed a reduction in the intensity of the absorption band related to O-H stretching as a result of the dehydration process. Furthermore, elemental analysis results showed an increase in the carbon content and a decrease in the hydrogen content at temperatures of 95, 150, 263 and 380 °C. Visually, darkening of the material was observed at 150 °C, indicating that the thermal decomposition of the material started at this temperature. At a temperature of 380 °C, thermal decomposition progressed, leading to a decrease in carbon and hydrogen. The results of thermogravimetry coupled with those of elemental analysis allow us to conclude that there was agreement between the percentages of phytic acid found in aqueous solution. The kinetic study by the non-isothermal thermogravimetric method showed that the dehydration process occurred in two stages. Dehydration step I promoted a process of vaporization of water (reaction order of zero), whereas dehydration step II showed an order of reaction equal to five. This change in reaction order was attributed to loss of chemically bonded water molecules of phytic acid or to the presence of volatile substances. Finally, the thermal decomposition step revealed an order of reaction equal to one. It was not possible to perform the kinetic study for other stages of mass loss.Uniterms: Thermal analysis. Phytic acid/thermal behavior. Emulsion/stability. IR/dehydration. EA/thermal decomposition.O ácido fítico é um composto natural muito utilizado como despigmentante em emulsões cosméticas magistrais. No entanto, observou-se experimentalmente que o ácido fítico, quando aquecido a 150 °C durante cerca de uma hora, mostra evidências de decomposição térmica e que poucos estudos envolvendo essa espécie, isoladamente quanto a sua estabilidade, estão disponíveis na literatura. Esse fato motivou o estudo de caracterização e de comportamento térmico dessa espécie, ...

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“…Dissolution experiments are an ideal system for comparing the influence of formulation parameters, such as those under investigation in this work. As a secondary analytical method, differential scanning calorimetry (DSC) provides an insight into the degree of interaction between drug and excipient (21,22). For example, the eutectic phase diagram for stearic acid and ibuprofen has been established, identifying two overlapping peaks for the melting temperatures (23).…”

Section: Introductionmentioning

confidence: 99%

Controlled Microwave Processing Applied to the Pharmaceutical Formulation of Ibuprofen

2011

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Abstract. The first successful development of controlled microwave processing for pharmaceutical formulations is presented and illustrated with a model drug (ibuprofen) and two excipients (stearic acid and polyvinylpyrrolidone). The necessary fine temperature control for formulation with microwave energy has been achieved using a uniquely modified microwave oven with direct temperature measurement and pulse-width modulation power control. In addition to comparing microwave and conventional heating, the effect of the presence of liquid (water) in aiding the mixing of the drug and excipient during formulation was also investigated. Analysis of the prepared formulations using differential scanning calorimetry and dissolution studies suggest that microwave and conventional heating produce similar products when applied to mixtures of ibuprofen and stearic acid. However, the differences were observed for the ibuprofen and polyvinylpyrrolidone formulation in terms of the dissolution kinetics. In all cases, the presence of water did not appear to influence the formulation to any appreciable degree. The application of controllable microwave heating is noteworthy as fine temperature control opens up opportunities for thermally sensitive materials for which microwave methods have not been feasible prior to this work.

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Thermal analysis study of the interactions between acetaminophen and excipients in solid dosage forms and in some binary mixtures

Cited by 68 publications

References 16 publications

Thermal Behavior and Free-Radical-Scavenging Activity of Phytic Acid Alone and Incorporated in Cosmetic Emulsions

Thermal Behavior and Free-Radical-Scavenging Activity of Phytic Acid Alone and Incorporated in Cosmetic Emulsions

Study of thermal behavior of phytic acid

Controlled Microwave Processing Applied to the Pharmaceutical Formulation of Ibuprofen

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