Thermal and photochemical behaviour of zn(II) complexes of some cephalosporins

Aly, Aref A. M.; Osman, Ahmed H.; El‐Maali, Nagwa Abo; Al‐Hazmi, Gamil A.A.

doi:10.1023/b:jtan.0000017338.52247.76

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…453,454 A similar activity should be expected of complexes of another tetrazole-containing antibiotic, cefamandole, with copper, 455 cadmium 456 and zinc 457 salts. An antibacterial activity was also found for silver tetrazolate 73 and complexes 40.…”

Section: Applications Of Metal Tetrazole Derivativesmentioning

confidence: 57%

Metal derivatives of tetrazoles

Гапоник¹,

2006

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Published data on the synthesis, structure, properties Published data on the synthesis, structure, properties and applications of metal derivatives of tetrazoles are generalised and applications of metal derivatives of tetrazoles are generalised and described systematically. Compounds based on the anionic and described systematically. Compounds based on the anionic and neutral tetrazole forms, and neutral tetrazole forms, C C-and -and N N-mono-and -mono-and C C, ,N N-disubsti--disubstituted tetrazoles are considered. The bibliography includes 464 tuted tetrazoles are considered. The bibliography includes 464 references references. . ReceivedDepending on the reaction conditions, meta-and para-5,5 Hphenyleneditetrazoles 25 react with Cd, Zn and Mn(II) salts to give essentially different, as regards both composition and structure, complexes 26, 27, 44 28, 45 29. 46 The structures of compounds 26 ± 29 were determined by X-ray diffraction. Compounds 26 ± 28 in which the doubly charged anions derived from tetrazole 25 function as bridges are two-and three-dimensional coordination polymers. Conversely, compound 29 is a mononuclear aqua complex containing no metal ± tetrazole coordination bond. In the structure of complex 28, one-dimensional channels were found which occupy up to 35% of the void volume and encapsulate tetrameric cyclic water clusters and DMF molecules. On heating to 150 8C, water and DMF are removed from the channels, which accounts for the interest of researchers in this type of compound for the preparation of inclusion compounds and sorbents. A coordination polymer with a composition similar to complex K + 7

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Section: Applications Of Metal Tetrazole Derivativesmentioning

confidence: 57%

Metal derivatives of tetrazoles

Гапоник¹,

2006

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“…Cephalosporin antibiotics have long been known to behave as relatively efficient chelating agents 7 . A list of clinically used chelating agents may be found in most pharmacopoeia, while new chelating agents continue to be sought 8,9 …”

Section: Introductionmentioning

confidence: 99%

Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes

Auda

Mrestani

Nies

et al. 2009

Journal of Pharmacy and Pharmacology

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“…Cephalosporin antibiotics have long been known to behave as relatively efficient chelating agents. [7] A list of clinically used chelating agents may be found in most pharmacopoeia, while new chelating agents continue to be sought. [8,9] The medicinal uses of metal complexes are of increasing clinical and commercial importance.…”

Section: Introductionmentioning

confidence: 99%

Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes

Auda¹,

Mrestani²,

Nies³

et al. 2009

j pharm pharmacol

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Objectives Cefodizime is a broad spectrum cephalosporin belonging to the third generation agents. In this study, attention has been paid to the preparation, physicochemical characterization and biological evaluation of new Cu 2+ , Zn 2+ , Fe 3+ , Co 2+ and Al 3+ complexes of cefodizime. Methods The stoichiometrics and the mode of bonding of the complexes were deduced from their elemental and metal analysis, electrical conductivity measurements, UV-vis, infrared and Raman spectroscopic investigations. Study of the stoichiometry of these complexes referred to the formation of 1 : 1 ratios of metal to ligand. Antimicrobial activity of the complexes was determined using two strains of Gram-positive (Bacillus subtilis and Proteus vulgaris) and two strains of Gram-negative (Escherichia coli W3110 and Pseudomonas putida) bacteria. The minimal inhibitory concentration was determined as the lowest concentration inhibiting bacterial growth on solid Luria Bertani medium. Key findings The spectra gave evidence as to the position of binding. In addition, the aqueous solubility of cefodizime was strongly reduced by complexation. Conclusions The antibacterial activity of cefodizime was not affected by complexation with Al 3+ but it was reduced by complexation with the other tested metal ions against the bacteria under study.

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Thermal and photochemical behaviour of zn(II) complexes of some cephalosporins

Cited by 8 publications

References 17 publications

Metal derivatives of tetrazoles

Metal derivatives of tetrazoles

Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes

Preparation, physicochemical characterization and biological evaluation of cefodizime metal ion complexes

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