Thermal behavior of hydrophobically modified hydrogels using TGA/FTIR/MS analysis technique

Rusu, Alina Gabriela; Popa, Marcel; Lisă, Gabriela; Vereştiuc, Liliana

doi:10.1016/j.tca.2015.05.018

Cited by 45 publications

(22 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2a–f). To understand the thermal behavior, as an indication of the collagen degradation in the different scaffolds 26,27 , we have performed thermogravimetric analysis (TGA). The thermal degradation characteristics are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

3D Structure and Processing Methods Direct the Biological Attributes of ECM-Based Cardiac Scaffolds

Efraim

Schoen

Zahran

et al. 2019

Sci Rep

View full text Add to dashboard Cite

High hopes are held for cardiac regenerative therapy, driving a vast research effort towards the development of various cardiac scaffolds using diverse technologies and materials. Nevertheless, the role of factors such as fabrication process and structure in determining scaffold’s characteristics is yet to be discovered. In the present study, the effects of 3D structure and processing method on cardiac scaffolds are addressed using three distinct scaffolds made through different production technologies from the same biomaterial: decellularized porcine cardiac extracellular matrix (pcECM). pcECM patch, injectable pcECM hydrogel, and electrospun pcECM scaffolds were all proven as viable prospective therapies for MI, thus generally preserving pcECM beneficial properties. Yet, as we demonstrate, minor differences in scaffolds composition and micro-morphology as well as substantial differences in their mechanical properties, which arise from their production process, highly affect the interactions of the scaffold with both proliferating cells and functional cells. Hence, the rates of cell attachment, survival, and proliferation significantly vary between the different scaffolds. Moreover, major differences in cell morphology and alignment as well as in matrix remodeling are obtained. Overall, the effects revealed herein can guide a more rational scaffold design for the improved cellular or acellular treatment of different cardiac disease scenarios.

show abstract

Section: Resultsmentioning

confidence: 99%

3D Structure and Processing Methods Direct the Biological Attributes of ECM-Based Cardiac Scaffolds

Efraim

Schoen

Zahran

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In the same time, the thermal characterization of materials could provide relevant data concerning the stability, the effect of sterilization methods or storage conditions, useful insights for biomedical applications where the sterilization stage is required (Rusu et al, 2015).…”

Section: Thermal Behaviourmentioning

confidence: 99%

Biotinylated N-palmitoyl chitosan for design of drug loaded self-assembled nanocarriers

Bǎlan

Redinciuc

Tudorachi³

et al. 2016

European Polymer Journal

View full text Add to dashboard Cite

“…In general, the networks with more β-sheets start to degrade at a higher temperature, with the hydrogels synthesised from 360 mg/ mL Val NCA solution displaying significant degradation at 160°C greater than the initial network and cryogels synthesised from 360 mg/mL Val NCA solution displaying significant degradation at 40°C greater than the initial network. A thermal degradation process atypical for hydrophobically modified networks was observed with two distinct stages, implying the hybrid structure with different phases 57 . In the wake of a slow mass drop, a much steeper mass loss occurred to β-sheet-incorporated networks from 300 to 400°C, due to the progressive decomposition of β-sheet crystals in this temperature range 58 .…”

mentioning

confidence: 98%

Spider-silk inspired polymeric networks by harnessing the mechanical potential of β-sheets through network guided assembly

Chan

Tan

et al. 2020

Nat Commun

View full text Add to dashboard Cite

The high toughness of natural spider-silk is attributed to their unique β-sheet secondary structures. However, the preparation of mechanically strong β-sheet rich materials remains a significant challenge due to challenges involved in processing the polymers/proteins, and managing the assembly of the hydrophobic residues. Inspired by spider-silk, our approach effectively utilizes the superior mechanical toughness and stability afforded by localised βsheet domains within an amorphous network. Using a grafting-from polymerisation approach within an amorphous hydrophilic network allows for spatially controlled growth of poly (valine) and poly(valine-r-glycine) as β-sheet forming polypeptides via N-carboxyanhydride ring opening polymerisation. The resulting continuous β-sheet nanocrystal network exhibits improved compressive strength and stiffness over the initial network lacking β-sheets of up to 30 MPa (300 times greater than the initial network) and 6 MPa (100 times greater than the initial network) respectively. The network demonstrates improved resistance to strong acid, base and protein denaturants over 28 days.

show abstract

Thermal behavior of hydrophobically modified hydrogels using TGA/FTIR/MS analysis technique

Cited by 45 publications

References 32 publications

3D Structure and Processing Methods Direct the Biological Attributes of ECM-Based Cardiac Scaffolds

3D Structure and Processing Methods Direct the Biological Attributes of ECM-Based Cardiac Scaffolds

Biotinylated N-palmitoyl chitosan for design of drug loaded self-assembled nanocarriers

Spider-silk inspired polymeric networks by harnessing the mechanical potential of β-sheets through network guided assembly

Contact Info

Product

Resources

About