Thermal Behavior of the Nimesulide-Salicylic Acid Eutectic Mixtures Prepared by Mechanosynthesis and Recrystallization

Abstract

Nimesulide, salicylic acid and their binary mixtures were studied by differential scanning calorimetry (DSC) and Fourier Transform Infrared spectroscopy (FTIR). The study of such systems is a promising and viable approach for solving the problem of poor solubility of materials in general and drug systems in particular. All areas of human activity are inextricably linked to materials, and thus, the study presented in the paper and not reported in the literature is very important and provides useful data for those working in various fields. The eutectic mixtures were obtained by mechanosynthesis and by recrystallization from ethanol over the entire 0–1 range of molar fractions. For both situations at the molar fraction of nimesulide 0.5, the mixture has a eutectic that suggests an increase in solubility at this composition. The interactions that take place between the components were determined with the help of the excess thermodynamic functions (GE, SE, µE), which highlight the deviation from the ideality of the considered binary systems.

Mechanochemical synthesis of drug–drug eutectics of the antibacterial agent, linezolid

“…13,33 Differential Scanning Calorimetry (DSC) is the most prevalent, accurate, and practical technique employed to ascertain the formation of eutectics and is further augmented by hot-stage microscopy (HSM). 10 The thermal study of LZD and its eutectic composites confirm a single endothermic process corresponding to the first-order solid-liquid phase transition (melting) in the temperature ranging from 60 to 200 °C (Fig. 1).…”

“…[6][7][8][9] Further, with suitable water-soluble excipients, eutectics confer better wettability to the drug and hence improve its bioavailability. [10][11][12][13] The increased surface area of the components confers to dissolution rate increments at par with amorphous solids and solid dispersions. 14,15 The use of eutectics in pharmaceutical formulations is quite advantageous because (1) in a eutectic, the crystalline constituents make it more stable than its amorphous counterparts; (2) eutectics are easy to synthesize and scale up; and (3) because they are not considered new chemical entities, they do not require clinical trials.…”

Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures

“…FTIR spectroscopy is a useful tool in the investigation of molecular interactions appearing between the API components of physical mixtures [ 22 , 23 , 24 , 25 , 26 ]. Pure ibuprofen, ketoprofen, and drotaverine hydrochloride were the subject of several FTIR studies [ 27 , 28 , 29 , 30 , 31 , 32 ] using different techniques but to the best of our knowledge, their mixtures were never studied before.…”

Bio-Hybrid Hydrogels Incorporated into a System of Salicylic Acid-pH/Thermosensitive Nanocarriers Intended for Cutaneous Wound-Healing Processes

“…The first transformation is related to the evaporation of water in the structure of the materials, while the second one relates to the beginning of the phenomenon of the degradation of polymers. The endothermic peak observed in the case of SA and T-SA with a maximum of 156 • C may be attributed to the first-order solid-liquid phase transition of salicylic acid [65,66]. Interestingly, this peak was not observed in the case of the composition with a pH-sensitive nanocarrier.…”