2011
DOI: 10.3109/03639045.2010.534099
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Thermal behavior study and decomposition kinetics of amiodarone hydrochloride under isothermal conditions

Abstract: Thermogravimetry (TG) and differential scanning calorimetry (DSC) are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drugs and excipient molecules, such as polymorphism, stability, purity, formulation compatibility, among others. AMI presents a thermal stability of up to 431 K and a fusion onset temperature of 432 K. The drug has proven to be incompatible with magnesium stearate, eskis red pigment,… Show more

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Cited by 25 publications
(24 citation statements)
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“…Any change in the quality of a class II drug caused by stability problems directly influences the bioavailability of the drug (Yoshida et al, 2010(Yoshida et al, , 2011.…”
Section: Introductionmentioning
confidence: 99%
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“…Any change in the quality of a class II drug caused by stability problems directly influences the bioavailability of the drug (Yoshida et al, 2010(Yoshida et al, , 2011.…”
Section: Introductionmentioning
confidence: 99%
“…The t 90 is often interpreted as the shelf-life of a drug. This is calculated through an extrapolation of the Arrhenius equation, and the value determines the drug lifetime at 298 K (Cides et al, 2006;Yoshida et al, 2010Yoshida et al, , 2011.…”
Section: Introductionmentioning
confidence: 99%
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“…Kinetic studies were conducted under acid and basic conditions, according to the model adjustments reported in the literature [14]. Given the analytical results, the order of the degradation reactions was established according to the models of zero, first, and second orders, calculated by applying the linear correlation coefficient (r).…”
Section: Methodsmentioning
confidence: 99%