Thermal behavior study and decomposition kinetics of amisulpride under non-isothermal and isothermal conditions

Removal of organic pollutants (pharmaceuticals and pesticides) from sewage sludge by hydrothermal carbonization using response surface methodology (RSM)

“…Nevertheless, in some cases compounds are resistant to the applied temperatures, resulting in their residual detection in the produced hydrochar. According to Salama et al ., the decomposition of AMS occurs in two different steps with a first mass loss (C 9 H 12 SO 3 N molecule) in the temperature range 202–390 °C and a second loss (C 6 H 12 N and CH 3 NO) in the temperature range 393.41–726.86 °C 53 . Furthermore, carbamazepine and amitriptyline require decomposition temperatures higher than 377 °C and 270 °C, respectively, 54,55 while thermal decomposition of chlorpyrifos under inert and oxidative conditions was achieved at temperatures higher than 550 °C 56 .…”

“…According to Salama et al, the decomposition of AMS occurs in two different steps with a first mass loss (C 9 H 12 SO 3 N molecule) in the temperature range 202-390 °C and a second loss (C 6 H 12 N and CH 3 NO) in the temperature range 393.41-726.86 °C. 53 Furthermore, carbamazepine and amitriptyline require decomposition temperatures higher than 377 °C and 270 °C, respectively, 54,55 while thermal decomposition of chlorpyrifos under inert and oxidative conditions was achieved at temperatures higher than 550 °C. 56 Thus, runs 4, 10 and 13, with lower reaction temperatures and time, exhibited decreased removal rates (64.79%, 66% and 55.79%, respectively) compared to runs 2, 3 and 6 employing higher temperatures and decomposition efficiencies (79.1%, 83.11% and 88.63%, respectively).…”

Self-assembled ruthenium decorated electrochemical platform for sensitive and selective determination of amisulpride in presence of co-administered drugs using safranin as a mediator

“…Serotonergic antidepressants are one of the first line agents for treatment of depression [3]. Amisulpride (AMS) is a substituted benzamide atypical antipsychotic that has high affinity for dopamine receptors toward management of psychoses such as schizophrenia [4,5]. AMS obviously has the clinical profile of an atypical antipsychotic [6], known by its lower propensity to induce extrapyramidal side effects as well as its greater efficacy in treating negative symptoms compared to classical neuroleptics, particularly haloperidol which was used as comparative substance in most studies [6].…”

“…AMS has IUPAC name; 4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2methoxybenzamide. Citalopram (CIT), chemically 1- propyl]-1-(4fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, belongs to selective serotonin reuptake inhibitors (SSRIs) family [5]. About 30%-40% of Alzheimer's disease patients have depressive and psychotic symptoms [8].…”

Thermal decomposition kinetics of the antiparkinson drug “entacapone” under isothermal and non-isothermal conditions

“…While mainly used for the analytical determination of target analytes, thermal analytical techniques can provide important data regarding the storage and stability of drugs [16][17][18]. The most widely used thermal analysis techniques are thermogravimetry / derivative thermogravimetry (TG/DTG), differential thermal analysis (DTA) and differential scanning calorimetry (DSC) [18][19][20]. These techniques are widely used in the pharmaceutical sciences for the characterization of solid drugs and excipients.…”