Thermal behaviour of antiproliferative active 3-(2-furanyl)-8-aryl-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-ones

Abstract

Thermal analysis is commonly used in the pharmaceutical field because it is an important tool in the solution of problems involving development, production and quality control of medicines. This paper presents the thermal behaviour of six anticancer active derivativestriazin-4(6H)-one. The samples were characterized by the TG-DSC and TG-FTIR analyses. The studied compounds are stable at room temperature which is important for medical application. The TG analysis under dynamic air atmosphere revealed that thermal degradation of the compounds starts above 300°C and proceeds in two steps. The melting processes of compounds are observed before starting their decomposition or at the beginning of their combustion. Pyrolysis processes under nitrogen atmosphere take place in single or two steps. The major pyrolysis gaseous products identified are ammonia, carbon dioxide, isocyanic acid and its derivatives, hydrogen cyanide, aniline or its derivatives and carbon monoxide.

Thermal properties and decomposition mechanism of disubstituted fused 1,2,4-triazoles considered as potential anticancer and antibacterial agents

“…Otherwise, the emission of NH 3 (bands at 931 cm −1 and 966 cm −1 connecting with the N-H deformation vibrations and as the signals at ca. 3350 cm −1 derived from the N-H stretching vibrations [25][26][27] and HCN (band at 713 cm −1 ) is observed [29,30]. Apart from the emission of these gases, the formation of H 2 O and CO 2 is confirmed.…”

“…The characteristic absorption bands for ammonia are appeared as two signals at 931 cm −1 and 966 cm −1 connecting with the N-H deformation vibrations and as the signals at ca. 3350 cm −1 derived from the N-H stretching vibrations [25][26][27][28]. Apart from the emission of NH 3 during the first decomposition stage, the evolution of HCN molecule is also observed.…”

Predicting the Blood-Brain Barrier Permeability of New Drug-Like Compounds via HPLC with Various Stationary Phases

“…All pharmaceutically relevant compounds [19,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] were resynthesized in our laboratory for the current research purposes and their structures, belonging to particular groups, are listed in Table 1. They have been shown to possess mainly promising anticancer [19,[21][22][23][24][25][26][27][28][29][30]32], analgesic [19,21,31,33], antiviral and antihaemolytic [27] activities.…”

Thermal and spectroscopic studies of 2,3,5-trisubstituted and 1,2,3,5-tetrasubstituted indoles as non-competitive antagonists of GluK1/GluK2 receptors

“…The melting point onset temperature (T onset ), peak temperature (T peak ) corresponding to each peak, and enthalpy of fusion taken from the DSC curves for all compounds are listed in Table 1. The melting peaks are sharp which indicates that the compounds were probably synthesised as pure, crystalline substances [31][32][33]. Generally, the substitution of the pyrrole hydrogen atom in position 1 leads to a decreased melting point.…”

“…The double peaks in the range 2050-2275 cm -1 correspond to the vibrations of CO molecule. The characteristic bands of water molecules are observed in the range 3450-4000 and 1300-1950 cm -1 for stretching and deformation vibrations, respectively [31,32,34]. Probably other compounds such as indole can be condensed in the transfer line and do not reach the detector.…”