Thermal characteristics of Hydroxypropyl Methyl Cellulose

Lim, Woo-Sub; Choi, Ji‐Won; Iwata, Yusaku; Kitamura, Hiroshi

doi:10.1016/j.jlp.2008.11.003

Cited by 14 publications

(12 citation statements)

References 6 publications

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“…While the pure cellulose is not soluble in water because of the intramolecular hydrogen bonding, which highly limits the utilization of cellulose in a large number of technical applications and products. [10][11][12] Since blending polymers provides a very attractive technique to generate new materials, we have tried to mix the collagen and HPMC to obtain new materials for medical application such as controlled-release. 8,9 Hydroxypropyl methylcellulose (HPMC), which is a typical nonionic polysaccharide, is a hydrophilic cellulose ether derivative and has been extensively used as a matrix for drug delivery as well as used in adhesives and cosmetics.…”

Section: Introductionmentioning

confidence: 99%

Rheological properties of collagen/hydroxypropyl methylcellulose (COL/HPMC) blended solutions

Ding

Zhang

2013

J of Applied Polymer Sci

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Collagen/HPMC blends with different HPMC content (HC) were investigated by dynamic responses, creep recovery, thixotropy, and morphological observation. Storage modulus, loss modulus, complex viscosity, and activation energy decreased with the increased HC, while the flow behavior index increased with the increased HC and the dynamic denaturation temperature reached the maximum as HC increased to 50%, indicating that the flowability and thermal stability of collagen solution were improved by the addition of HPMC. However, the blends with higher HC tended to have a relatively lower recovery capacity, and the hysteresis loop areas of the blends were lower than that of collagen (especially when HC > 50%). Additionally, the morphology of collagen/ HPMC was examined by both of atomic force microscopy and scanning electron microscopy. By combining with these results, it seemed that the rheological and structural properties of collagen/HPMC were related to the hydrogen-bond interaction and compatibility between collagen and HPMC molecules.

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Section: Introductionmentioning

confidence: 99%

Rheological properties of collagen/hydroxypropyl methylcellulose (COL/HPMC) blended solutions

Ding

Zhang

2013

J of Applied Polymer Sci

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“…Pyrolysis of the cellulose and HPMC (see the inset of Fig. 6 A for the molecular structure of HPMC) was described in [ 15 – 17 , 19 , 20 , 46 – 50 ] based on the GC-MS (gas chromatography paired with mass spectrometry), thermogravimetry, as well as DFT (density functional theory) data. Practically all papers report on the thermal decomposition in N 2 , introducing numerous reaction pathways, most of which are true to some extent observed in real experiments.…”

Section: Resultsmentioning

confidence: 99%

Thermal degradation of Affinisol HPMC: Optimum Processing Temperatures for Hot Melt Extrusion and 3D Printing

Svoboda,

Nevyhoštěná,

Macháčková

et al. 2023

Pharm Res

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Purpose Affinisol HPMC HME is a new popular form of hypromellose specifically designed for the hot melt extrusion and 3D printing of pharmaceutical products. However, reports of its thermal stability include only data obtained under inert N2 atmosphere, which is not consistent with the common pharmaceutical practice. Therefore, detailed investigation of its real-life thermal stability in air is paramount for identification of potential risks and limitations during its high-temperature processing. Methods In this work, the Affinisol HPMC HME 15LV powder as well as extruded filaments will be investigated by means of thermogravimetry, differential scanning calorimetry and infrared spectroscopy with respect to its thermal stability. Results The decomposition in N2 was proceeded in accordance with the literature data and manufacturer’s specifications: onset at ~260°C at 0.5°C·min−1, single-step mass loss of 90–95%. However, in laboratory or industrial practice, high-temperature processing is performed in the air, where oxidation-induced degradation drastically changes. The thermogravimetric mass loss in air proceeded in three stages: ~ 5% mass loss with onset at 150°C, ~ 70% mass loss at 200°C, and ~ 15% mass loss at 380°C. Diffusion of O2 into the Affinisol material was identified as the rate-determining step. Conclusion For extrusion temperatures ≥170°C, Affinisol exhibits a significant degree of degradation within the 5 min extruder retention time. Hot melt extrusion of pure Affinisol can be comfortably performed below this temperature. Utilization of plasticizers may be necessary for safe 3D printing.

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“…As noted earlier, determining the oxidative selfheating of a sample in a wire mesh cube requires a large amount of sample, a 24-h testing span and trials at several temperatures [1]. In contrast, oxidative self-heating measured using an SIT can evaluate the hazard of oxidative self-heating using a small sample mass but requires up to 7 days per test and the use of several temperatures [2][3][4][5][6]. The above tests are isothermal measurements, whereas the test using a DAC represents a scanning analysis.…”

Section: Resultsmentioning

confidence: 99%

“…This apparatus is able to adiabatically control the heat exchange between a sample and the surrounding atmosphere, even when working with sample amounts of only several milliliters. To date, the SIT apparatus has been frequently applied to evaluate the hazard of heat generation by oxidation, particularly in Japan [4][5][6]. However, when using this technique, both a long measurement time span and measurements at several temperatures are required because isothermal measurements are performed, just as with the oxidative self-heating test of samples in a wire mesh cube described above.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the hazard of heat generation by oxidation of materials using a differential-type adiabatic calorimeter

Sato

2015

J Therm Anal Calorim

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The rapid evaluation of the hazard of heat generation by oxidation of materials using a differentialtype adiabatic calorimeter (DAC) was investigated, assessing oleic acid and polyethylene glycol samples of various masses. The same samples were analyzed using an accelerating rate calorimeter and a high-sensitivity calorimeter (C80), for comparison purposes. The kinetic parameters of the exothermic reactions were determined from the C80 data, and the associated exothermic behaviors of the samples were compared with those observed using the DAC. Oleic acid exhibited self-heating at lower temperatures compared with polyethylene glycol according to each measurement method. Thus, the comparative risk of heat generation of chemical materials by oxidation may be evaluated using a DAC. The DAC technique allows the prediction of exothermic behavior based on a single measurement performed over the course of a single day. Thus, the assessment of autoxidation exothermic behaviors using a DAC may be applied to allow rapid screening of the hazard of heat generation induced by oxidation of chemical substances.

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Thermal characteristics of Hydroxypropyl Methyl Cellulose

Cited by 14 publications

References 6 publications

Rheological properties of collagen/hydroxypropyl methylcellulose (COL/HPMC) blended solutions

Rheological properties of collagen/hydroxypropyl methylcellulose (COL/HPMC) blended solutions

Thermal degradation of Affinisol HPMC: Optimum Processing Temperatures for Hot Melt Extrusion and 3D Printing

Evaluation of the hazard of heat generation by oxidation of materials using a differential-type adiabatic calorimeter

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