Thermal degradation of amphetamine sulphate

Gomez, Jacques; Bruneau, Christian; Soyer, N.; Brault, Auguste

doi:10.1016/0165-2370(85)80102-9

Cited by 2 publications

(1 citation statement)

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“…According to the literature the free amphetamine base formed after thermal decomposition of amphetamine sulphate, was also pyrolyzed by the rupture of the benzyl C-C bond [9]. In contrast to amphetamine hydrochloride, the sulphate salt is not volatile enough under +Ph-CH 2 (m/z = 91) C § (m/z = 44, base peak) the GC-MS conditions, and it was irregularly pyrolyzed in the injector during measurements.…”

Section: Resultsmentioning

confidence: 98%

The role of self-protonation under direct GC-MS determination of amphetamine hydrochloride

2001

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SummaryWe studied the possibility of direct GC-MS determination of amphetamine hydrochloride. In order to avoid the double peak we determined the optimal injector temperature (260 ~ and heating rate (40 ~ min-1). In the direct analysis of amphetamine hydrochloride containing samples, calibration for fragment m/z = 59 (originating from amphetaminium ion fragmentation; the calibrating agent is amphetamine hydrochloride) gave better results than calibration for m/z = 44 (derived from both free amphetamine and amphetaminium ion; calibration agents were amphetamine or amphetamine hydrochloride). We also compared the mass spectra of amphetamine and amphetamine hydrochloride taken by ion-trap GC-MS. The fragmentation pathway of the amphetamine and amphetaminium ion was different. The main fragmentation path was cleavage of the C-C bond at benzyl position for the free base or between the phenyl group and the aliphatic moiety, in the case of free base and amphetaminium ion, respectively

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Section: Resultsmentioning

confidence: 98%