Thermal desorption-capillary gas chromatography for the quantitative analysis of dimethyl sulphate, diethyl sulphate and ethylene oxide in the workplace

Headspace sampling with in situ carbodiimide-mediated derivatization for the determination of ibuprofen in water samples

“…The values obtained when dimethyl sulfate is used as the derivatization reagent [12] in the headspace mode, with the use of a microextraction fibre in the solid phase, is around 0.3 ng/L. However, this derivatization reaction has the disadvantage that that dimethyl sulfate is known to be highly toxic and carcinogenic [39,40].…”