This paper presents a novel resin concrete obtained by adding cubic zirconium tungstate (ZrW2O8) as filler. A prediction algorithm on the thermal expansion coefficient (CTE) of resin concrete (including filler) was established on the basis of the meso-mechanics method and a three-phase model for concrete. The concept of twice mixing was also proposed for prediction accuracy. Then, a 2D and 3D irregular polygon aggregate particles packing model was set up by Matlab and the properties of the packing model were simulated by finite element analysis. Finally, resin concrete samples were made and their CTE were measured. Mix proportion and addition of ZrW2O8 as influencing factors were considered in this experiment. The CTE of resin concrete was verified by comparing results of the prediction model, simulation model and experiment. The optimum CTE obtained from the experiment was 1.504 × 10 /K without ZrW2O8, it was found that the addition of ZrW2O8 to resin concrete can make it perform significantly better in thermal expansion.