Thermal Inkjet Application in the Preparation of Oral Dosage Forms: Dispensing of Prednisolone Solutions and Polymorphic Characterization by Solid-State Spectroscopic Techniques

Meléndez, Peter A.; Kane, Kevin M.; Ashvar, C. S.; Ma, Qing; Smith, Pamela

doi:10.1002/jps.21189

Cited by 113 publications

(78 citation statements)

References 11 publications

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“…This idea originated from the same technique used in computer-operated inkjet printing which recreates digital images by propelling ink droplets onto paper. It was adapted for pharmaceutical application by the replacement of the ink with pharmaceutical solutions containing drugs and normal paper with edible sheets known as substrates (22,23). A list of the possible substrates that could be used in ink jet printing has be compiled in a review by Alomari et al, (2014) (24).…”

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confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such as extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, including design flexibility and control and manufacture which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

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confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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“…The most intuitive entry point for pharmaceutical secondary manufacturing by inkjet printing is the delivery of active materials to a film of rapidly dissolving polymer for oral dosing, with examples of products listed in an early review paper by Sastra et al Melendez et al 2008, shows that small molecule drugs can be delivered in a format useful for industry to solve the challenge of water solubility. A similar approach is used for dosing to tablets, with GSK developing a technique for late stage customisation and functionalisation of an inactive tablet structure (GSK 2014).…”

Section: Oral Dose Developmentmentioning

confidence: 99%

“…The main carrier fluids used in pharmaceutical inkjet printing are water (Sharma et al, Pardeike et al, Rattanakit et al, Mueannoom et al, Sharma et al, Marizza et al), DMSO (Boehm et al 2011, 2013, Gu et al 2012, ethanol (Scoutaris et al 2011, Raijada et al 2013, Melendez et al 2008) and acetone (Scoutaris et al 2012, Wu et al 2009). The role of the carrier fluid can be either to (i) dissolve the API, (ii) act as an immiscible carrier phase in a colloidal dispersion, and/or (iii) evaporate at a controlled rate after printing to deliver the pharmaceutical component in the appropriate solid form.…”

Section: Carrier Fluidmentioning

confidence: 99%

“…Once research includes the final inkjet devices, the effect of nozzle flow on pharmaceutically active molecules can also be examined quantitatively to ensure that their functionality is unimpaired. For example, Melendez et al 2008 showed that there was no effect on the small molecule drug prednisolone when printed with the Hewlett-Packard 970 Cxi DeskJet thermal DoD personal printer. The manufacturing and underlying scientific research need to be closely aligned here because formulations tested and qualified on one printhead still may need considerable modification to work optimally on a different device.…”

Section: ) Gesim A010-201mentioning

confidence: 99%

“…It is highly likely that biopharmaceuticals will be significantly affected, based on similar bioprinting experiments (Cook et al 2010). While control of formulation (specifically excipient or polymeric components) is shown to influence pharmaceutical crystallisation (Trasi et al 2012), Melendez et al (2008) hypothesise that the control of the inkjet printing parameters may lead to selectivity of polymorphs. This is reinforced by the work of Zhang et al (2004) who examined the interconversion among polymorphs due to processing techniques.…”

Section: Nozzle Flow Influencesmentioning

confidence: 99%

See 2 more Smart Citations

Inkjet printing for pharmaceutics – A review of research and manufacturing

Daly

Harrington

Martin

et al. 2015

International Journal of Pharmaceutics

274

185

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Abstract:Global regulatory, manufacturing and consumer trends are driving a need for change in current pharmaceutical sector business models, with a specific focus on the inherently expensive research costs, high-risk capital-intensive scale-up and the traditional centralised batch manufacturing paradigm. New technologies, such as inkjet printing, are being explored to radically transform pharmaceutical production processing and the end-to-end supply chain. This review provides a brief summary of inkjet printing technologies and their current applications in manufacturing before examining the business context driving the exploration of inkjet printing in the pharmaceutical sector. We then examine the trends reported in the literature for pharmaceutical printing, followed by the scientific considerations and challenges facing the adoption of this technology. We demonstrate that research activities are highly diverse, targeting a broad range of pharmaceutical types and printing systems. To mitigate this complexity we show that by categorising findings in terms of targeted business models and Active Pharmaceutical Ingredient (API) chemistry we have a more coherent approach to comparing research findings and can drive efficient translation of a chosen drug to inkjet manufacturing.

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Biopolymers and Cells

Calvert

Boland

2012

Inkjet Technology for Digital Fabrication

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Thermal Inkjet Application in the Preparation of Oral Dosage Forms: Dispensing of Prednisolone Solutions and Polymorphic Characterization by Solid-State Spectroscopic Techniques

Cited by 113 publications

References 11 publications

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Inkjet printing for pharmaceutics – A review of research and manufacturing

Biopolymers and Cells

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