Integrated Power Electronics Modules (IPEMs) represent an innovative typology of power electronics assemblies able to guarantee several advantages such as increasing of power density, better management of the thermal flows and a significant reduction of the package sizes. Their characteristics make them suitable for applications like motor drives or power conditioning. IPEMs usage in emerging fields like hybrid automotive traction and electric generation from renewable energy sources is continuously increasing. In this paper, we describe the implementation of a devised flow to generate the layer-based electro-thermal PSpice model of an IPEM and the simulation flow of the model. The proposed modeling methodology allows reducing an electro-thermal multi-domain problem to an electrical single one. The general PSpice-like nature of the proposed model makes it suitable for a wide range of simulation frameworks where the integration of heterogeneous multi-physics models could be a difficult task. The outlining of both electrical and thermal PSpice layers is discussed, and the implementation into the final model, by the assistance of custom electronic design automation (EDA) flow, is presented. Besides, we describe the validation procedure of the proposed approach and the results are compared with the ones obtained by a commercial finiteelement-based package used as a benchmark. Two simulation approaches related to specific conversion systems, and related issues, are presented and discussed.